Výsledky vyhledávání - "S A, Spindler"

Vitamin D receptor displays DNA binding and transactivation as a heterodimer with the retinoid X receptor, but not with the thyroid hormone receptor

Autor: P D, Thompson, J C, Hsieh, G K, Whitfield, C A, Haussler, P W, Jurutka, M A, Galligan, J B, Tillman, S R, Spindler, M R, Haussler

Publikováno v: Journal of cellular biochemistry. 75(3)

The vitamin D receptor (VDR) is a transcription factor believed to function as a heterodimer with the retinoid X receptor (RXR). However, it was reported [Schräder et al., 1994] that, on putative vitamin D response elements (VDREs) within the rat 9k

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b07c02b917b956fde93b865647000b14
https://pubmed.ncbi.nlm.nih.gov/10536369

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3,5,3'-L-triiodothyronine (thyroid hormone)-induced protein-DNA interactions in the thyroid hormone response elements and cell type-specific elements of the rat growth hormone gene revealed by in vivo dimethyl sulfate footprinting

Autor: W R, Force, S R, Spindler

Publikováno v: The Journal of biological chemistry. 269(13)

The cell type-specific element and 3,5,3'-L-triiodothyronine (thyroid hormone) (T3) response element of the rat growth hormone gene act synergistically to produce cell type-specific, T3-regulated expression. Pit-1 is a pituitary cell type-specific tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a37742b1bab6d4409c24403490db0738
https://pubmed.ncbi.nlm.nih.gov/8144557

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Homodimer and heterodimer DNA binding and transcriptional responsiveness to triiodothyronine (T3) and 9-cis-retinoic acid are determined by the number and order of high affinity half-sites in a T3 response element

Autor: W R, Force, J B, Tillman, C N, Sprung, S R, Spindler

Publikováno v: The Journal of biological chemistry. 269(12)

T3 (triiodothyronine) response elements (TREs) consist of pairs of strong and weak (S and W), 10-nucleotide T3 receptor (TR) monomer binding sites (half-sites). We report that the number and order of S and W half-sites in a direct repeat TRE determin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0617241042e4b3ca599388c97c439084
https://pubmed.ncbi.nlm.nih.gov/8132622

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Alpha and beta thyroid hormone receptors bind immediately adjacent to the rat growth hormone gene TATA box in a negatively hormone-responsive promoter region

Autor: D E, Crone, H S, Kim, S R, Spindler

Publikováno v: The Journal of biological chemistry. 265(19)

We report that alpha and beta type rat thyroid hormone receptors bind specifically and with high affinity to the 10-base pair sequence immediately 3' of the rat growth hormone TATA box (positions -25 to -16) in a region of the rat growth hormone prom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::989bb359ca019dc01873f3592c3ef91f
https://pubmed.ncbi.nlm.nih.gov/2358443

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Thyroid hormone regulation of the transfected rat growth hormone promoter

Autor: S R Spindler, M D Crew

Publikováno v: Journal of Biological Chemistry. 261:5018-5022

A region of the rat growth hormone gene and 5' flanking DNA has been identified which promotes accurate, thyroid hormone-regulated transcriptional initiation. GC rat pituitary tumor cells were transfected with chimaeric plasmids containing various le

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eaf247a810646bbb7ecd9e5cb8d4a28c
https://doi.org/10.1016/s0021-9258(19)89208-6

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DNA-dependent RNA polymerase II from Acanthamoeba castellanii. Large scale preparation and subunit composition

Autor: M R Paule, J M D'Alessio, S R Spindler

Publikováno v: Journal of Biological Chemistry. 254:4085-4091

DNA-dependent RNA polymerase II from Acuntha- moeba castellanii has been purified to homogeneity as judged by native and sodium dodecyl sulfate polyacryl- amide gel electrophoresis. The initial stages of purifi- cation utilize low ionic strength extr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::56b9bbf2425403a3db32106f15660696
https://doi.org/10.1016/s0021-9258(18)50699-2

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