Výsledky vyhledávání

Quantitation of Total and Free Thiol Angiotensinogen as a Prognostic Marker for Preeclampsia

Autor: M, Qi, James C, Weaver, S, Rahgozar, B, Giannakopoulos, S A, Krilis

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1967

Angiotensinogen mediates an important role in the pathophysiology of preeclampsia, a disorder of pregnancy characterized by hypertension and proteinuria usually after 20 weeks of gestation. Angiotensinogen is found in two distinct posttranslational f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::75d2cb36d4448028d34cc4537ea7073a
https://pubmed.ncbi.nlm.nih.gov/31069778

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Site-directed mutagenesis of recombinant human beta 2-glycoprotein I identifies a cluster of lysine residues that are critical for phospholipid binding and anti-cardiolipin antibody activity

Autor: Y Sheng, A Sali, H Herzog, J Lahnstein, S A Krilis

Publikováno v: The Journal of Immunology. 157:3744-3751

beta2-Glycoprotein I (beta2GPI) is a phospholipid-binding serum protein with anticoagulant properties. It plays a vital role in the binding of anti-cardiolipin Abs purified from patients with autoimmune disease when assayed in a cardiolipin (CL) ELIS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::65a9018577313498f690369a92291c57
https://doi.org/10.4049/jimmunol.157.8.3744

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Mast cells expressing chymase but not tryptase can be derived by culturing human progenitors in conditioned medium obtained from a human mastocytosis cell strain with c-kit ligand

Autor: L Li, X W Meng, S A Krilis

Publikováno v: The Journal of Immunology. 156:4839-4844

Human mast cells (MC) were derived from umbilical cord blood and bone marrow progenitors cultured in the presence of a conditioned medium from a human mastocytosis cell strain and recombinant human kit ligand. MCs were studied using a sequential doub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e2c0cb286bca579e56de59e60880ee17
https://doi.org/10.4049/jimmunol.156.12.4839

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Monoclonal antibodies from NZW x BXSB F1 mice to beta2 glycoprotein I and cardiolipin. Species specificity and charge-dependent binding

Autor: M Monestier, D A Kandiah, S Kouts, K E Novick, G L Ong, M Z Radic, S A Krilis

Publikováno v: The Journal of Immunology. 156:2631-2641

NZW x BXSB F1 mice develop a systemic autoimmune syndrome with various lupus-like manifestations. Male animals develop a degenerative coronary disease with myocardial infarction, resulting in death before 6 mo of age. The presence in these mice of an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9fa33ab70f8f000f542c0b0b51cc5f91
https://doi.org/10.4049/jimmunol.156.7.2631

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Epitope specificity of monoclonal anti-beta 2-glycoprotein I antibodies derived from patients with the antiphospholipid syndrome

Autor: M X Wang, D A Kandiah, K Ichikawa, M Khamashta, G Hughes, T Koike, R Roubey, S A Krilis

Publikováno v: The Journal of Immunology. 155:1629-1636

beta 2-Glycoprotein I (beta 2GPI) has been identified as a cofactor in the recognition of the phospholipid Ag cardiolipin (CL) by anticardiolipin Ab (aCL) purified from patients with autoimmune diseases. However, there is considerable controversy as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::59a119b74483c4df6bf6ef168644fc95
https://doi.org/10.4049/jimmunol.155.3.1629

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Immunization of a rabbit with beta 2-glycoprotein I induces charge-dependent crossreactive antibodies that bind anionic phospholipids and have similar reactivity as autoimmune anti-phospholipid antibodies

Autor: S Kouts, M X Wang, S Adelstein, S A Krilis

Publikováno v: The Journal of Immunology. 155:958-966

A rabbit immunized with beta 2-glycoprotein I (beta 2-GPI) produced Abs that bind to negatively charged phospholipids and to beta 2-GPI. After affinity purification of the Abs to beta 2-GPI, the dual reactivity could still be detected. Adsorption stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f4b1f48c468a97f822907be06b0b78ed
https://doi.org/10.4049/jimmunol.155.2.958

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Continuous release of secretory granule proteoglycans from a cell strain derived from the bone marrow of a patient with diffuse cutaneous mastocytosis

Autor: S A, Krilis, K F, Austen, J L, Macpherson, C F, Nicodemus, M F, Gurish, R L, Stevens

Publikováno v: Blood. 79:144-151

A human cell strain (designated HBM-M) that was derived from the bone marrow of a child with diffuse cutaneous mastocytosis was previously found to possess features that suggested it belonged in the mast cell/monocyte lineage. HBM-M cells synthesized

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07599a373c77a5f9fad7d667cc1e457b
https://doi.org/10.1182/blood.v79.1.144.bloodjournal791144

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Current insights into the 'antiphospholipid' syndrome: clinical, immunological, and molecular aspects

Autor: D A, Kandiah, A, Sali, Y, Sheng, E J, Victoria, D M, Marquis, S M, Coutts, S A, Krilis

Publikováno v: Advances in immunology. 70

Advances in defining the target antigen(s) for the autoantibodies in the APS highlight the inadequacies of the current classification of these autoantibodies into anticardiolipin and LA antibodies. The discovery that beta 2GPI is the target antigen f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e7387026a7acb0817c6ebc88a3d1fc1c
https://pubmed.ncbi.nlm.nih.gov/9755344

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