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A12 STEPWISE COORDINATION OF COLONIC NEUTROPHILS AND INNATE LYMPHOID CELLS IN THE ONSET AND RESOLUTION OF CLOSTRIDIOIDES DIFFICILE TOXIN-INDUCED INJURY

Autor: K L Flannigan, A Serra, S A Hirota

Publikováno v: Journal of the Canadian Association of Gastroenterology. 5:14-15

Background While our understanding and use of treatments for Clostridioides difficile infection (CDI) has improved, initial CDI still carries significant morbidity and mortality owing to heterogeneity in host immune responses. Further, host immunity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c8f6bb43e4b8d8e60047f969a559f2da
https://doi.org/10.1093/jcag/gwab049.011

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A20 INTESTINAL SMOOTH MUSCLE AND FIBROSTENOSIS: TARGETING NR4A1 TO MODULATE PROLIFERATIVE SIGNALLING

Autor: J Lee, H E Szczepanski, K L Flannigan, S A Hirota

Publikováno v: Journal of the Canadian Association of Gastroenterology. 5:23-24

Background Fibrostenotic Crohn’s Disease (CD), presenting with intestinal fibrosis and stricture formation, has a substantial impact on patient quality of life. Given our poor understanding of its etiology, we lack viable preventative and therapeut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f6080b95a64c1ab894329d5378b163e
https://doi.org/10.1093/jcag/gwab049.019

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Attenuation ofClostridium difficiletoxin-induced damage to epithelial barrier by ecto-5′-nucleotidase (CD73) and adenosine receptor signaling

Autor: L P, Schenck, L Patrick, Schenck, S A, Hirota, C L, Hirota, P, Boasquevisque, S E, Tulk, Y, Li, A, Wadhwani, C T A, Doktorchik, W K, Macnaughton, P L, Beck, J A, MacDonald

Publikováno v: Neurogastroenterology & Motility. 25:e441-e453

Background Clostridium difficile (Cdf) releases toxins (TcdA and TcdB) that damage the intestinal epithelial barrier. Ecto-5′-nucleotidase (CD73) is expressed on intestinal epithelial cells, and it is hypothesized to protect against toxin-induced e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0c42b5d8b11608acaba9f566ad296bb
https://doi.org/10.1111/nmo.12139

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Differential effects of salvinorin A on endotoxin-induced hypermotility and neurogenic ion transport in mouse ileum

Autor: J, Fichna, M, Dicay, S A, Hirota, D, Traboulsi, J A, Macdonald, A, Janecka, P L, Beck, J K, Zjawiony, W K, Macnaughton, M A, Storr

Publikováno v: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 23(6)

Salvinorin A (SA) is the principal active ingredient of Salvia divinorum, with an established inhibitory action on gastrointestinal (GI) transit and colonic ion transport in mice. Under normal conditions, the effects of SA are mediated by kappa opioi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bae7c766a625ba48a114789094fd4a47
https://pubmed.ncbi.nlm.nih.gov/21414104

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Glycolysis of red cells suspended in solutions of impermeable solutes. Intracellular pH and glycolysis

Autor: A, Tomoda, S, Tsuda-Hirota, S, Minakami

Publikováno v: Journal of biochemistry. 81(3)

The glycolytic rate human red cells suspended in a sucrose medium of low or physiological pH was higher than that of the cells suspended in Ringer's medium of the same. pH. The medium pHP-glycolytic rate curve of red cells suspended in soucrose media

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b294fccdfe95bc7f7dd813216a821a76
https://pubmed.ncbi.nlm.nih.gov/16876

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