Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Søren Thirup"'
Autor:
Camilla Gustafsen, Ditte Olsen, Joachim Vilstrup, Signe Lund, Anika Reinhardt, Niels Wellner, Torben Larsen, Christian B. F. Andersen, Kathrin Weyer, Jin-ping Li, Peter H. Seeberger, Søren Thirup, Peder Madsen, Simon Glerup
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
PCSK9 interacts with LDL receptor, causing its degradation, and consequently reduces the clearance of LDL. Here, Gustafsen et al. show that PCSK9 interacts with heparan sulfate proteoglycans and this binding favors LDLR degradation. Pharmacological i
Externí odkaz:
https://doaj.org/article/e6df4a8d335842ca8793c25354c164bc
Autor:
Gitte Vestergaard Lohmann, Yoshikazu Shimoda, Mette Wibroe Nielsen, Frank Grønlund Jørgensen, Christina Grossmann, Niels Sandal, Kirsten Sørensen, Søren Thirup, Lene Heegaard Madsen, Satoshi Tabata, Shusei Sato, Jens Stougaard, Simona Radutoiu
Publikováno v:
Molecular Plant-Microbe Interactions, Vol 23, Iss 4, Pp 510-521 (2010)
LysM receptor kinases were identified as receptors of acylated chitin (Nod factors) or chitin produced by plant-interacting microbes. Here, we present the identification and characterization of the LysM receptor kinase gene (Lys) family (17 members)
Externí odkaz:
https://doaj.org/article/f5b8e22cf2d54022981bfbc0099e1d0b
Autor:
Anita S. Bek, Jørgen Sauer, Mikkel B. Thygesen, Jens Ø. Duus, Bent O. Petersen, Søren Thirup, Euan James, Knud J. Jensen, Jens Stougaard, Simona Radutoiu
Publikováno v:
Molecular Plant-Microbe Interactions, Vol 23, Iss 1, Pp 58-66 (2010)
Formation of functional nodules is a complex process depending on host–microsymbiont compatibility in all developmental stages. This report uses the contrasting symbiotic phenotypes of Lotus japonicus and L. pedunculatus, inoculated with Mesorhizob
Externí odkaz:
https://doaj.org/article/c2cc6f9827904d138834f28a1bebd3cf
Autor:
Mads Kjolby, Peter Breining, Karen Pedersen, Niels Wellner, Karen Sørensen, Anette Gjessing, Dovile Januliene, Dorthe Vittrup, Arulmani Manavalan, Maarten Rotman, Gangadaar Thotakura, Guido Hermey, Peder Madsen, Christian Vaegter, Søren Thirup, Olof Asplund, Rashmi Prasad, Edwin Parlevliet, Patrick Rensen, Andreas Madsen, Birgitte Holst, Olav Andersen, Arne Moller, Torben Hansen, Anders Nykjaer
Type 2 diabetes has reached endemic proportions and is a substantial burden for the affected patients and the society. Along with lifestyle factors, a number of genetic loci predisposing to type 2 diabetes have been identified, including SORCS1 that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec672209d92bb95a06749b31dbc88c6e
https://doi.org/10.21203/rs.3.rs-1299440/v1
https://doi.org/10.21203/rs.3.rs-1299440/v1
Autor:
Kerstin Mahr, Mette Nyegard, Joachim Jankowski, Marina Augusto Heuschkel, Simon Winther, Morten Bøttcher, Nadine Kaesler, Vera Jankowski, Anika Himmelsbach, Juliane Hermann, Nikolaus Marx, Stefan J Schunk, Thimoteus Speer, Anders Nykjaer, Turgay Saritas, Søren Thirup, Claudia Goettsch, Mads Kjolby, Juergen Floege, Rafael Kramann
Publikováno v:
Jankowski, V, Saritas, T, Kjolby, M, Hermann, J, Speer, T, Himmelsbach, A, Mahr, K, Heuschkel, M A, Schunk, S J, Thirup, S, Winther, S, Bottcher, M, Nyegard, M, Nykjaer, A, Kramann, R, Kaesler, N, Jankowski, J, Floege, J, Marx, N & Goettsch, C 2022, ' Carbamylated sortilin associates with cardiovascular calcification in patients with chronic kidney disease ', Kidney International, vol. 101, no. 3, pp. 574-584 . https://doi.org/10.1016/j.kint.2021.10.018
Kidney international 101(3), 574-584 (2022). doi:10.1016/j.kint.2021.10.018
Jankowski, V, Saritas, T, Kjolby, M, Hermann, J, Speer, T, Himmelsbach, A, Mahr, K, Heuschkel, M A, Schunk, S J, Thirup, S, Winther, S, Bottcher, M, Nyegaard, M, Nykjaer, A, Kramann, R, Kaesler, N, Jankowski, J, Floege, J, Marx, N & Goettsch, C 2022, ' Carbamylated sortilin associates with cardiovascular calcification in patients with chronic kidney disease. ', Kidney International, vol. 101, no. 3, pp. 574-584 . https://doi.org/10.1016/j.kint.2021.10.018
Kidney international 101(3), 574-584 (2022). doi:10.1016/j.kint.2021.10.018
Jankowski, V, Saritas, T, Kjolby, M, Hermann, J, Speer, T, Himmelsbach, A, Mahr, K, Heuschkel, M A, Schunk, S J, Thirup, S, Winther, S, Bottcher, M, Nyegaard, M, Nykjaer, A, Kramann, R, Kaesler, N, Jankowski, J, Floege, J, Marx, N & Goettsch, C 2022, ' Carbamylated sortilin associates with cardiovascular calcification in patients with chronic kidney disease. ', Kidney International, vol. 101, no. 3, pp. 574-584 . https://doi.org/10.1016/j.kint.2021.10.018
Kidney international 101(3), 574-584 (2022). doi:10.1016/j.kint.2021.10.018
Published by Elsevier, New York, NY
Published by Elsevier, New York, NY
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4594dad627c9fca6fde138eeb0cebce1
https://pubmed.ncbi.nlm.nih.gov/35190032
https://pubmed.ncbi.nlm.nih.gov/35190032
Autor:
Rashmi B. Prasad, Torben Hansen, Patrick C.N. Rensen, Sune Skeldal, Dorthe Maria Vittrup, Karen M. Pedersen, Olof Asplund, Christian Bjerggaard Vaegter, Anette Marianne Prior Gjessing, Andreas N. Madsen, Karen Marie Juul Sørensen, Mads Kjolby, Maarten Rotman, Dovile Januliene, Olav M. Andersen, Guido Hermey, Edwin T. Parlevliet, Birgitte Holst, Arne Moller, Gangadaar Thotakura, Ernst-Martin Füchtbauer, Søren Thirup, Peder Madsen, Niels Wellner, Peter Breining, Arulmani Manavalan
Type II diabetes mellitus (T2DM) has reached endemic levels and comprises a substantial burden to the patient and the society. Along with lifestyle factors, a number of genetic loci predisposing to T2DM have been suggested including SORCS1 that encod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbdadf328d061149c37f06c00ea13f49
https://doi.org/10.1101/2020.11.10.376178
https://doi.org/10.1101/2020.11.10.376178
Autor:
Joachim Vilstrup, Jeppe Lyngsø, Dorthe Strandbygård, Amanda Simonsen, Thea G. Birkefeldt, Jan Skov Pedersen, Søren Thirup
Publikováno v:
Vilstrup, J, Simonsen, A, Birkefeldt, T, Strandbygård, D, Lyngsø, J, Pedersen, J S & Thirup, S 2020, ' Crystal and solution structures of fragments of the human leucocyte common antigen-related protein ', Acta crystallographica Section D: Structural biology, vol. 76, pp. 406-417 . https://doi.org/10.1107/S2059798320003885
Leucocyte common antigen-related protein (LAR) is a post-synaptic type I transmembrane receptor protein that is important for neuronal functionality and is genetically coupled to neuronal disorders such as attention deficit hyperactivity disorder (AD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4028916ec570bef92dd12f008516def
https://pure.au.dk/portal/da/publications/crystal-and-solution-structures-of-fragments-of-the-human-leucocyte-common-antigenrelated-protein(a035c049-1513-4023-9561-8dc42a776af4).html
https://pure.au.dk/portal/da/publications/crystal-and-solution-structures-of-fragments-of-the-human-leucocyte-common-antigenrelated-protein(a035c049-1513-4023-9561-8dc42a776af4).html
Autor:
Jacob Flyvholm Cramer, Peder Madsen, Lone Tjener Pallesen, Camilla Gustafsen, Claus Munck Petersen, Steen V. Petersen, Søren Thirup
Publikováno v:
Molecular and Cellular Biology
Pallesen, L T, Gustafsen, C, Cramer, J, Petersen, S V, Thirup, S S, Madsen, P & Petersen, C M 2020, ' PAK kinases targets sortilin and modulates its sorting ', Molecular and Cellular Biology, vol. 40, no. 3, e00411-19 . https://doi.org/10.1128/MCB.00411-19
Pallesen, L T, Gustafsen, C, Cramer, J, Petersen, S V, Thirup, S S, Madsen, P & Petersen, C M 2020, ' PAK kinases targets sortilin and modulates its sorting ', Molecular and Cellular Biology, vol. 40, no. 3, e00411-19 . https://doi.org/10.1128/MCB.00411-19
The multifunctional type 1 receptor sortilin is involved in endocytosis and intracellular transport of ligands. The short intracellular domain of sortilin binds several cytoplasmic adaptor proteins (e.g., the AP-1 complex and GGA1 to -3), most of whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e08197a4c91b050e8bce077ec5045f1
http://europepmc.org/articles/PMC6965034
http://europepmc.org/articles/PMC6965034
Autor:
Christian Brix Folsted Andersen, Jin-Ping Li, Joachim Vilstrup, Simon Glerup, Camilla Gustafsen, Peder Madsen, Søren Thirup, Anika Reinhardt, Kathrin Weyer, Torben Larsen, Niels Wellner, Signe Lund, Peter H. Seeberger, Ditte Olsen
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Gustafsen, C, Olsen, D, Vilstrup, J, Lund, S, Reinhardt, A, Wellner, N, Larsen, T, Andersen, C B F, Weyer, K, Li, J-P, Seeberger, P H, Thirup, S, Madsen, P & Glerup, S 2017, ' Heparan sulfate proteoglycans present PCSK9 to the LDL receptor ', Nature Communications, vol. 8, no. 1, pp. 503 . https://doi.org/10.1038/s41467-017-00568-7
Nature Communications
Gustafsen, C, Olsen, D, Vilstrup, J, Lund, S, Reinhardt, A, Wellner, N, Larsen, T, Andersen, C B F, Weyer, K, Li, J-P, Seeberger, P H, Thirup, S, Madsen, P & Glerup, S 2017, ' Heparan sulfate proteoglycans present PCSK9 to the LDL receptor ', Nature Communications, vol. 8, no. 1, pp. 503 . https://doi.org/10.1038/s41467-017-00568-7
Nature Communications
Coronary artery disease is the main cause of death worldwide and accelerated by increased plasma levels of cholesterol-rich low-density lipoprotein particles (LDL). Circulating PCSK9 contributes to coronary artery disease by inducing lysosomal degrad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54b9c9a06332998a9d20f0f662317a56
http://link.springer.com/article/10.1038/s41467-017-00568-7
http://link.springer.com/article/10.1038/s41467-017-00568-7
Autor:
Niels Sandal, Jens Stougaard, Daniel Couto, Lene H. Madsen, Mette Uldum-Berentsen, Svend Dam, Marcin Nadzieja, Mickaël Blaise, Simona Radutoiu, Veit Schwämmle, Søren Thirup, Frank L.H. Menke, Mette H Asmussen, Kasper R. Andersen, Fábio C. S. Nogueira, Jaslyn E. M. M. Wong, Cyril Zipfel, Christoph A. Bücherl, Sina Schroeder, Paul Derbyshire
Publikováno v:
Wong, J E M M, Nadzieja, M, Madsen, L H, Bücherl, C A, Dam, S, Sandal, N N, Couto, D, Derbyshire, P, Uldum-Berentsen, M, Schroeder, S, Schwämmle, V, Nogueira, F C S, Asmussen, M H, Thirup, S, Radutoiu, S, Blaise, M, Andersen, K R, Menke, F L H, Zipfel, C & Stougaard, J 2019, ' A Lotus japonicus cytoplasmic kinase connects Nod factor perception by the NFR5 LysM receptor to nodulation ', Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 28, pp. 14339-14348 . https://doi.org/10.1073/pnas.1815425116
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, pp.201815425. ⟨10.1073/pnas.1815425116⟩
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, pp.201815425. ⟨10.1073/pnas.1815425116⟩
Significance Legume receptors perceive Nod factor signal molecules at the plasma membrane of epidermal cells and initiate a signal transduction process that leads to the development of root nodules that house nitrogen-fixing rhizobia. Nodule organs a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1e25d35af311b510a83e0a50bde5bf0
https://pure.au.dk/ws/files/194272657/A_Lotus_japonicus_cytoplasmic_kinase_connects_Nod_factor_perception_by_the_NFR5_LysM_receptor_to_nodulation.pdf
https://pure.au.dk/ws/files/194272657/A_Lotus_japonicus_cytoplasmic_kinase_connects_Nod_factor_perception_by_the_NFR5_LysM_receptor_to_nodulation.pdf