Zobrazeno 1 - 10
of 216
pro vyhledávání: '"Søren R, Paludan"'
Autor:
Jonas Govaerts, Elise Van Breedam, Sarah De Beuckeleer, Charlotte Goethals, Claudio Peter D’Incal, Julia Di Stefano, Siebe Van Calster, Tamariche Buyle-Huybrecht, Marlies Boeren, Hans De Reu, Søren R. Paludan, Marc Thiry, Marielle Lebrun, Catherine Sadzot-Delvaux, Helena Motaln, Boris Rogelj, Johan Van Weyenbergh, Winnok H. De Vos, Wim Vanden Berghe, Benson Ogunjimi, Peter Delputte, Peter Ponsaerts
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Varicella-zoster virus (VZV) encephalitis and meningitis are potential central nervous system (CNS) complications following primary VZV infection or reactivation. With Type-I interferon (IFN) signalling being an important first line cellular defence
Externí odkaz:
https://doaj.org/article/a886acf2bf824812b60e03bc4e9326a1
Autor:
Isara Alee, Papasara Chantawichitwong, Asada Leelahavanichkul, Søren R. Paludan, Trairak Pisitkun, Prapaporn Pisitkun
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract The absence of stimulator of interferon genes (STING) in 129.B6.Fcgr2b-deficient mice rescue lupus phenotypes. The administration of a STING inhibitor (ISD017) into the young 129.B6.Fcgr2b-deficient mice prevents lupus nephritis development.
Externí odkaz:
https://doaj.org/article/3510b9f412524a89b9490c74e10aa2e6
Autor:
Bao-cun Zhang, Marlene F. Laursen, Lili Hu, Hossein Hazrati, Ryo Narita, Lea S. Jensen, Aida S. Hansen, Jinrong Huang, Yan Zhang, Xiangning Ding, Maimaitili Muyesier, Emil Nilsson, Agnieszka Banasik, Christina Zeiler, Trine H. Mogensen, Anders Etzerodt, Ralf Agger, Mogens Johannsen, Emil Kofod-Olsen, Søren R. Paludan, Martin R. Jakobsen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The cGAS-STING pathway plays a crucial role in anti-tumoral responses by activating inflammation and reprogramming the tumour microenvironment. Upon activation, STING traffics from the endoplasmic reticulum (ER) to Golgi, allowing signalling
Externí odkaz:
https://doaj.org/article/d5f211afbe2146aea0d8433928886c3f
Autor:
Demi van der Horst, Naziia Kurmasheva, Mikkel H. S. Marqvorsen, Sonia Assil, Anna H. F. Rahimic, Christoph F. Kollmann, Leandro Silva da Costa, Qi Wu, Jian Zhao, Eleonora Cesari, Marie B. Iversen, Fanghui Ren, Trine I. Jensen, Ryo Narita, Vivien R. Schack, Bao-cun Zhang, Rasmus O. Bak, Claudio Sette, Robert A. Fenton, Jacob G. Mikkelsen, Søren R. Paludan, David Olagnier
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract DNA is a danger signal sensed by cGAS to engage signaling through STING to activate innate immune functions. The best-studied downstream responses to STING activation include expression of type I interferon and inflammatory genes, but STING
Externí odkaz:
https://doaj.org/article/0db80e2a99374afa9c136a61eb6b74e2
Autor:
Björn Becker, Felix Wottawa, Mohamed Bakr, Eric Koncina, Lisa Mayr, Julia Kugler, Guang Yang, Samuel J. Windross, Laura Neises, Neha Mishra, Danielle Harris, Florian Tran, Lina Welz, Julian Schwärzler, Zoltán Bánki, Stephanie T. Stengel, Go Ito, Christina Krötz, Olivia I. Coleman, Christian Jaeger, Dirk Haller, Søren R. Paludan, Richard Blumberg, Arthur Kaser, Luka Cicin-Sain, Stefan Schreiber, Timon E. Adolph, Elisabeth Letellier, Philip Rosenstiel, Johannes Meiser, Konrad Aden
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109173- (2024)
Summary: Inflammatory bowel diseases are characterized by the chronic relapsing inflammation of the gastrointestinal tract. While the molecular causality between endoplasmic reticulum (ER) stress and intestinal inflammation is widely accepted, the me
Externí odkaz:
https://doaj.org/article/b82b754dd2874bbc89024fd998a49788
Autor:
Ensieh Farahani, Line S. Reinert, Ryo Narita, Manutea C. Serrero, Morten Kelder Skouboe, Demi van der Horst, Sonia Assil, Baocun Zhang, Marie B. Iversen, Eugenio Gutierrez, Hossein Hazrati, Mogens Johannsen, David Olagnier, Reiner Kunze, Mark Denham, Trine H. Mogensen, Michael Lappe, Søren R. Paludan
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113792- (2024)
Summary: Pattern recognition receptors (PRRs) induce host defense but can also induce exacerbated inflammatory responses. This raises the question of whether other mechanisms are also involved in early host defense. Using transcriptome analysis of di
Externí odkaz:
https://doaj.org/article/44f664b9af4a437aa62a40c3c3077e62
Autor:
Azadeh Reyahi, Marie Studahl, Morten K. Skouboe, Stefanie Fruhwürth, Ryo Narita, Fanghui Ren, Moa Bjerhem Viklund, Marie B. Iversen, Mette Christiansen, Alexandra Svensson, Trine H. Mogensen, Kristina Eriksson, Søren R. Paludan
Publikováno v:
JCI Insight, Vol 8, Iss 21 (2023)
The mechanisms underlying susceptibility to recurrent herpes simplex virus type 2 (HSV-2) meningitis remain incompletely understood. In a patient experiencing multiple episodes of HSV-2 meningitis, we identified a monoallelic variant in the IKBKE gen
Externí odkaz:
https://doaj.org/article/1ad2f5e9dd7e402595f5a7e6d67ef040
Autor:
Cyrielle Fougeroux, Louise Goksøyr, Manja Idorn, Vladislav Soroka, Sebenzile K. Myeni, Robert Dagil, Christoph M. Janitzek, Max Søgaard, Kara-Lee Aves, Emma W. Horsted, Sayit Mahmut Erdoğan, Tobias Gustavsson, Jerzy Dorosz, Stine Clemmensen, Laurits Fredsgaard, Susan Thrane, Elena E. Vidal-Calvo, Paul Khalifé, Thomas M. Hulen, Swati Choudhary, Michael Theisen, Susheel K. Singh, Asier Garcia-Senosiain, Linda Van Oosten, Gorben Pijlman, Bettina Hierzberger, Tanja Domeyer, Blanka W. Nalewajek, Anette Strøbæk, Magdalena Skrzypczak, Laura F. Andersson, Søren Buus, Anette Stryhn Buus, Jan Pravsgaard Christensen, Tim J. Dalebout, Kasper Iversen, Lene H. Harritshøj, Benjamin Mordmüller, Henrik Ullum, Line S. Reinert, Willem Adriaan de Jongh, Marjolein Kikkert, Søren R. Paludan, Thor G. Theander, Morten A. Nielsen, Ali Salanti, Adam F. Sander
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Here the authors generate a capsid-like particle based vaccine candidate displaying the receptor-binding domain of the SARS-CoV-2 spike protein and show induction of neutralizing antibodies after intramuscular prime-boost immunization in mice.
Externí odkaz:
https://doaj.org/article/c047e4469bfc4df49317bf7ddb5a7a95
Autor:
Ariane Volkmann, Gerrit Koopman, Petra Mooij, Ernst J. Verschoor, Babs E. Verstrepen, Willy M. J. M. Bogers, Manja Idorn, Søren R. Paludan, Søren Vang, Morten A. Nielsen, Adam F. Sander, Carolin Schmittwolf, Hubertus Hochrein, Paul Chaplin
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a worldwide pandemic. Here, we present non-human primate immunogenicity and protective efficacy data generated with the capsid virus-like particle (cVLP)-based vaccine ABNCoV2 th
Externí odkaz:
https://doaj.org/article/70276a3707f448aaac6b86a678a0b8dd
Autor:
David Olagnier, Ensieh Farahani, Jacob Thyrsted, Julia Blay-Cadanet, Angela Herengt, Manja Idorn, Alon Hait, Bruno Hernaez, Alice Knudsen, Marie Beck Iversen, Mirjam Schilling, Sofie E. Jørgensen, Michelle Thomsen, Line S. Reinert, Michael Lappe, Huy-Dung Hoang, Victoria H. Gilchrist, Anne Louise Hansen, Rasmus Ottosen, Camilla G. Nielsen, Charlotte Møller, Demi van der Horst, Suraj Peri, Siddharth Balachandran, Jinrong Huang, Martin Jakobsen, Esben B. Svenningsen, Thomas B. Poulsen, Lydia Bartsch, Anne L. Thielke, Yonglun Luo, Tommy Alain, Jan Rehwinkel, Antonio Alcamí, John Hiscott, Trine H. Mogensen, Søren R. Paludan, Christian K. Holm
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Viral infections usually cause disease through direct cytopathogenic effects and excessive inflammatory responses. Here, Olagnier et al. show that two NRF2 agonists, 4-OI and DMF, possess broad IFN-independent antiviral activity and decrease host inf
Externí odkaz:
https://doaj.org/article/7eb1ed3741cc4fbfa366937b0037cc35