BK channel activators and their therapeutic perspectives

Autor: Bo Hjorth Bentzen, Søren Peter Olesen, Lars Christian Rønn, Morten eGrunnet

Publikováno v: Frontiers in Physiology, Vol 5 (2014)

The large conductance calcium- and voltage- activated K+ channel (KCa1.1, BK, MaxiK) is ubiquitously expressed in the body, and holds the ability to integrate changes in intracellular calcium and membrane potential. This makes the BK channel an impor

Externí odkaz: https://doaj.org/article/9e40ece350784afc9247a214cecf3f00

KCNMA1 encoded cardiac BK channels afford protection against ischemia-reperfusion injury.

Autor: Ewa Soltysinska, Bo Hjorth Bentzen, Maria Barthmes, Helle Hattel, A Brianne Thrush, Mary-Ellen Harper, Klaus Qvortrup, Filip J Larsen, Tomas A Schiffer, Jose Losa-Reyna, Julia Straubinger, Angelina Kniess, Morten Bækgaard Thomsen, Andrea Brüggemann, Stefanie Fenske, Martin Biel, Peter Ruth, Christian Wahl-Schott, Robert Christopher Boushel, Søren-Peter Olesen, Robert Lukowski

Publikováno v: PLoS ONE, Vol 9, Iss 7, p e103402 (2014)

Mitochondrial potassium channels have been implicated in myocardial protection mediated through pre-/postconditioning. Compounds that open the Ca2+- and voltage-activated potassium channel of big-conductance (BK) have a pre-conditioning-like effect o

Externí odkaz: https://doaj.org/article/dbbff612b11847458ebf93062fcaf03b

Rare truncating variants in the sarcomeric protein titin associate with familial and early-onset atrial fibrillation

Autor: Ahmad Sajadieh, Stig Haunsø, Alicia Lundby, Gustav Ahlberg, Mattis F. Ranthe, Søren-Peter Olesen, Anders G. Holst, Morten S. Olesen, Jonas B. Nielsen, Simon Rasmussen, Nora Linscheid, Mads Melbye, Patrick T. Ellinor, Pia R. Lundegaard, Lu Camp, Laura Andreasen, Jesper Hastrup Svendsen, Lena Refsgaard

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Ahlberg, G, Refsgaard, L, Lundegaard, P R, Andreasen, L, Ranthe, M F, Linscheid, N, Nielsen, J B, Melbye, M, Haunsø, S, Sajadieh, A, Camp, L, Olesen, S-P, Rasmussen, S, Lundby, A, Ellinor, P T, Holst, A G, Svendsen, J H & Olesen, M S 2018, ' Rare truncating variants in the sarcomeric protein titin associate with familial and early-onset atrial fibrillation ', Nature Communications, vol. 9, no. 1, 4316 . https://doi.org/10.1038/s41467-018-06618-y
Nature Communications
Ahlberg, G, Refsgaard, L, Lundegaard, P R, Andreasen, L, Ranthe, M F, Linscheid, N, Nielsen, J B, Melbye, M, Haunsø, S, Sajadieh, A, Camp, L, Olesen, S-P, Rasmussen, S, Lundby, A, Ellinor, P T, Holst, A G, Svendsen, J H & Olesen, M S 2018, ' Rare truncating variants in the sarcomeric protein titin associate with familial and early-onset atrial fibrillation ', Nature Communications, vol. 9, 4316 . https://doi.org/10.1038/s41467-018-06618-y

A family history of atrial fibrillation constitutes a substantial risk of developing the disease, however, the pathogenesis of this complex disease is poorly understood. We perform whole-exome sequencing on 24 families with at least three family memb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c77613e3aa1288f6290140af0cbd1bf7
https://doaj.org/article/32b75a989a0d494f99383ba50d107a85

Analyse af tekst

Autor: Søren Peter Olesen, Line Thoft Carlsen

Publikováno v: Olesen, S P & Carlsen, L T 2018, Analyse af tekst . i M Merete & O Søren Peter (red), Forskningsmetode i socialt arbejde . 1. udgave udg, Hans Reitzels Forlag, København, s. 171-203 .
Aalborg University

I dette kapitel beskæftiger vi os med analyser med fokus på tekst: Hvilke analytiske greb kan bringes i anvendelse i forhold til tekstmateriale? Vi besvarer spørgsmålet ved at gennemgå udvalgte elementer i forskellige strategier på tværs af do

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::65fb174b3932da8a699a3812ca2756f0
https://vbn.aau.dk/da/publications/adb7b1e0-64e1-43ea-9ab7-9775b174c4f3

The two-pore domain potassium channel, TWIK-1, has a role in the regulation of heart rate and atrial size

Autor: Florian Lesage, Diane Fatkin, Jamie I. Vandenberg, Sylvain Feliciangeli, Inken G. Huttner, Alex Hørby Christensen, Søren-Peter Olesen, Franck C. Chatelain, Celine F. Santiago, Nicole Schmitt, Magdalena Soka, Claire Horvat, Morten S. Olesen

Publikováno v: Journal of Molecular and Cellular Cardiology
Journal of Molecular and Cellular Cardiology, Elsevier, 2016, 97, pp.24-35. ⟨10.1016/j.yjmcc.2016.04.006⟩

The two-pore domain potassium (K(+)) channel TWIK-1 (or K2P1.1) contributes to background K(+) conductance in diverse cell types. TWIK-1, encoded by the KCNK1 gene, is present in the human heart with robust expression in the atria, however its physio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25f5d0868a73b31d0422d3456e586d4d
https://doi.org/10.1016/j.yjmcc.2016.04.006