Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Søren Ottosen"'
Autor:
Hassan Javanbakht, Henrik Mueller, Johanna Walther, Xue Zhou, Anaïs Lopez, Thushara Pattupara, Julie Blaising, Lykke Pedersen, Nanna Albæk, Malene Jackerott, Tianlai Shi, Corinne Ploix, Wouter Driessen, Robert Persson, Jacob Ravn, John A.T. Young, Søren Ottosen
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 11, Iss C, Pp 441-454 (2018)
Chronic hepatitis B infection (CHB) is an area of high unmet medical need. Current standard-of-care therapies only rarely lead to a functional cure, defined as durable hepatitis B surface antigen (HBsAg) loss following treatment. The goal for next ge
Externí odkaz:
https://doaj.org/article/1962d4b211f2443bb9955ca1ed51da8a
Autor:
Josephine Schmaler, John A. T. Young, Philipp Tropberger, Xingchun Han, Henrik Mueller, Søren Ottosen, Lykke Pedersen, Hassan Javanbakht, Song Yang, Steffen Wildum, Yongguang Wang, Anaïs Lopez
Publikováno v:
Hepatology. 69:1398-1411
RG7834 is a potent, orally bioavailable small-molecule inhibitor of hepatitis B virus (HBV) gene expression that belongs to the dihydroquinolizinone (DHQ) chemical class and uniquely blocks production of both viral DNA and antigens. In this study, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8663aa0e5a0ff46c46c2c2542635ea1
https://doi.org/10.1002/hep.30329
https://doi.org/10.1002/hep.30329
Autor:
Lykke Pedersen, Robert Persson, Corinne Ploix, Xue Zhou, John A. T. Young, Thushara Pattupara, Hassan Javanbakht, Tianlai Shi, Johanna Walther, Julie Elisabeth Françoise Blaising, Henrik Mueller, Wouter H. P. Driessen, Nanna Albæk, Jacob Ravn, Anaïs Lopez, Søren Ottosen, Malene Jackerott
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 11, Iss C, Pp 441-454 (2018)
Molecular Therapy. Nucleic Acids
Molecular Therapy. Nucleic Acids
Chronic hepatitis B infection (CHB) is an area of high unmet medical need. Current standard-of-care therapies only rarely lead to a functional cure, defined as durable hepatitis B surface antigen (HBsAg) loss following treatment. The goal for next ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e7f5e083b00161c949a8777063fcc7d
https://doi.org/10.1016/j.omtn.2018.02.005
https://doi.org/10.1016/j.omtn.2018.02.005
Autor:
Eva van der Veer, Amy K. Patick, Leen-Jan van Doorn, Søren Ottosen, Michael R. Hodges, Lu Yang, Anneke K. Raney, K. Zeh, Todd B. Parsley
Publikováno v:
Antimicrobial Agents and Chemotherapy. 59:599-608
Miravirsen is a β- d -oxy-locked nucleic acid-modified phosphorothioate antisense oligonucleotide targeting the liver-specific microRNA-122 (miR-122). Miravirsen demonstrated antiviral activity against hepatitis C virus (HCV) genotype 1b replicons w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4635e0c7f702800a1a57fc9f18a5378f
https://doi.org/10.1128/aac.04220-14
https://doi.org/10.1128/aac.04220-14
Autor:
Michael Meldgaard, Troels Koch, Susanne Kammler, Peter Hagedorn, Anja Mølhart Høg, Victor Yakimov, Søren Ottosen, Morten Lindow, Henrik Ørum, Marianne R. Møller, Maj Hedtjärn, Niels Fisker Nielsen
Publikováno v:
Nucleic Acid Therapeutics. 23:302-310
Antisense oligonucleotides that recruit RNase H and thereby cleave complementary messenger RNAs are being developed as therapeutics. Dose-dependent hepatic changes associated with hepatocyte necrosis and increases in serum alanine-aminotransferase le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c947438fe0c61bdee66985b6ec8ded1
https://doi.org/10.1089/nat.2013.0436
https://doi.org/10.1089/nat.2013.0436
Autor:
Florian Then, David Baillat, Naoko Tanese, Sanford P. Markey, Jeffrey N. Savas, Anthony J. Makusky, Ramin Shiekhattar, Dimitri Krainc, Søren Ottosen
Publikováno v:
Proceedings of the National Academy of Sciences. 105:10820-10825
Huntington's disease is a dominant autosomal neurodegenerative disorder caused by an expansion of polyglutamines in the huntingtin (Htt) protein, whose cellular function remains controversial. To gain insight into Htt function, we purified epitope-ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1c9de888e3aebe389036f63a93b2a25
https://doi.org/10.1073/pnas.0800658105
https://doi.org/10.1073/pnas.0800658105
Autor:
Angela Hull, Francisco J. Herrera, Søren Ottosen, James R. Doroghazi, Steven J. Triezenberg, Sheenu Mittal, William S. Lane
Publikováno v:
Virology. 345:468-481
VP16 is a virion phosphoprotein of herpes simplex virus and a transcriptional activator of the viral immediate-early (IE) genes. We identified four novel VP16 phosphorylation sites (Ser18, Ser353, Ser411, and Ser452) at late times in infection but fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66f112e8878062e5641b8b143d971d59
https://doi.org/10.1016/j.virol.2005.10.011
https://doi.org/10.1016/j.virol.2005.10.011
Autor:
Kristian Harbo Bundsgaard, Tomas Ilginis, Henrik Vorum, Carl Uggerhøj Andersen, Søren Ottosen
Publikováno v:
Ilginis, T, Ottosen, S, Harbo Bundsgaard, K, Uggerhøj Andersen, C & Vorum, H 2012, ' Polypoidal choroidal vasculopathy in patients diagnosed with neovascular age-related macular degeneration in Denmark ', Acta Ophthamologica (Online), vol. 90, no. 6, pp. e487-8 . https://doi.org/10.1111/j.1755-3768.2011.02329.x
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c8c2e331585f53afdd5fbd603216b51
https://pubmed.ncbi.nlm.nih.gov/22280465
https://pubmed.ncbi.nlm.nih.gov/22280465
Publikováno v:
Science. 296:479-481
The proteasome is a garbage disposal unit in eukaryotic cells that degrades proteins tagged with ubiquitin molecules. In their Perspective, [Ottosen and colleagues][1] discuss new findings ([ Gonzalez et al .][2]) revealing that certain components of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d21c4fdb07535c03814eadd1c574b67
https://doi.org/10.1126/science.1071270
https://doi.org/10.1126/science.1071270