Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Søren Lykke-Andersen"'
Publikováno v:
STAR Protocols, Vol 5, Iss 2, Pp 102960- (2024)
Summary: The widespread usage of next-generation sequencing methods for functional genomics studies requires standardized tools for consistent visualization of the associated data. Here, we present seqNdisplayR, an R package for plotting standard seq
Externí odkaz:
https://doaj.org/article/bc6c83a796f34481a5de438bb715b75b
Autor:
Rikke H. Kofoed, Jin Zheng, Nelson Ferreira, Søren Lykke-Andersen, Mauro Salvi, Cristine Betzer, Lasse Reimer, Torben Heick Jensen, Karina Fog, Poul H. Jensen
Publikováno v:
Neurobiology of Disease, Vol 106, Iss , Pp 49-62 (2017)
Variations in the α-synuclein-encoding SNCA gene represent the greatest genetic risk factor for Parkinson's disease (PD), and duplications/triplications of SNCA cause autosomal dominant familial PD. These facts closely link brain levels of α-synucl
Externí odkaz:
https://doaj.org/article/bfab553617ee493ba6b5df1c23f583c4
Autor:
Sebastian Falk, Ksenia Finogenova, Mireille Melko, Christian Benda, Søren Lykke-Andersen, Torben Heick Jensen, Elena Conti
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
RBM7 and ZCCHC8 are two core subunits of the Nuclear Exosome Targeting complex, which regulates the degradation of selected non-coding RNAs in human cells. Here, the authors use structural and biochemical methods to show how ZCCHC8 recruits RBM7 in t
Externí odkaz:
https://doaj.org/article/eb3b13a071824d4d95e7463413ad6161
Publikováno v:
Rouvière, J O, Lykke-Andersen, S & Jensen, T H 2022, ' Control of non-productive RNA polymerase II transcription via its early termination in metazoans ', Biochemical Society Transactions, vol. 50, no. 1, pp. 283-295 . https://doi.org/10.1042/BST20201140
Transcription establishes the universal first step of gene expression where RNA is produced by a DNA-dependent RNA polymerase. The most versatile of eukaryotic RNA polymerases, RNA polymerase II (Pol II), transcribes a broad range of DNA including pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3beb41ed6d1b3b0ab2c53794218613f4
https://pure.au.dk/portal/da/publications/control-of-nonproductive-rna-polymerase-ii-transcription-via-its-early-termination-in-metazoans(2e51efe8-8e54-442c-8df6-f254eb0c2f49).html
https://pure.au.dk/portal/da/publications/control-of-nonproductive-rna-polymerase-ii-transcription-via-its-early-termination-in-metazoans(2e51efe8-8e54-442c-8df6-f254eb0c2f49).html
ARS2/SRRT:At the nexus of RNA polymerase II transcription, transcript maturation and quality control
Publikováno v:
Lykke-Andersen, S, Rouvière, J O & Jensen, T H 2021, ' ARS2/SRRT : At the nexus of RNA polymerase II transcription, transcript maturation and quality control ', Biochemical Society Transactions, vol. 49, no. 3, pp. 1325-1336 . https://doi.org/10.1042/BST20201008
ARS2/SRRT is an essential eukaryotic protein that has emerged as a critical factor in the sorting of functional from non-functional RNA polymerase II (Pol II) transcripts. Through its interaction with the Cap Binding Complex (CBC), it associates with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84fd28b013b3822a275a9c904f114305
https://pure.au.dk/portal/da/publications/ars2srrt(95a42392-9cf5-49c8-abc8-e29611fa5b63).html
https://pure.au.dk/portal/da/publications/ars2srrt(95a42392-9cf5-49c8-abc8-e29611fa5b63).html
Autor:
Jérôme O. Rouvière, Søren Lykke-Andersen, Carina Demel, Torben Heick Jensen, Manfred Schmid, Björn Schwalb, Guifen Wu, Kristina Žumer, Patrick Cramer, Ewa Šmidová Molska
Publikováno v:
Lykke-Andersen, S, Žumer, K, Molska, E Š, Rouvière, J O, Wu, G, Demel, C, Schwalb, B, Schmid, M, Cramer, P & Jensen, T H 2021, ' Integrator is a genome-wide attenuator of non-productive transcription ', Molecular Cell, vol. 81, no. 3, pp. 514-529.e6 . https://doi.org/10.1016/j.molcel.2020.12.014
Termination of RNA polymerase II (RNAPII) transcription in metazoans relies largely on the Cleavage and Polyadenylation (CPA) and Integrator (INT) complexes originally found to act at the ends of protein-coding and snRNA genes, respectively. Here we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::facf6d176a4df51f8f3fc72b44bc4d0b
https://pubmed.ncbi.nlm.nih.gov/33385327
https://pubmed.ncbi.nlm.nih.gov/33385327
Autor:
Yun Chen, Coline Gentil, Kristoffer Vitting-Seerup, Albin Sandelin, Nicola Meola, Evdoxia Karadoulama, Søren Lykke-Andersen, Michal Domanski, Torben Heick Jensen, Dennis Pultz, Jens S. Andersen
Publikováno v:
Meola, N, Domanski, M, Karadoulama, E, Chen, Y, Gentil, C, Pultz, D, Vitting-Seerup, K, Lykke-Andersen, S, Andersen, J S, Sandelin, A & Jensen, T H 2016, ' Identification of a Nuclear Exosome Decay Pathway for Processed Transcripts ', Molecular Cell, vol. 64, no. 3, pp. 520-533 . https://doi.org/10.1016/j.molcel.2016.09.025
Meola, N, Domanski, M, Karadoulama, E, Chen, Y, Gentil, C, Pultz, D, Vitting-Seerup, K, Lykke-Andersen, S, Andersen, J S, Sandelin, A G & Jensen, T H 2016, ' Identification of a Nuclear Exosome Decay Pathway for Processed Transcripts ', Molecular Cell, vol. 64, no. 3, pp. 520-533 . https://doi.org/10.1016/j.molcel.2016.09.025
Meola, N, Domanski, M, Karadoulama, E, Chen, Y, Gentil, C, Pultz, D, Vitting-Seerup, K, Lykke-Andersen, S, Andersen, J S, Sandelin, A G & Jensen, T H 2016, ' Identification of a Nuclear Exosome Decay Pathway for Processed Transcripts ', Molecular Cell, vol. 64, no. 3, pp. 520-533 . https://doi.org/10.1016/j.molcel.2016.09.025
The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its co-factor Mtr4p/hMTR4, which links to RNA-binding protein adaptors. One example is the trimeric human nuclear exosome targeting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3493f57fc824d756b9f8e28f82964c59
https://doi.org/10.1016/j.molcel.2016.09.025
https://doi.org/10.1016/j.molcel.2016.09.025
Autor:
Britt R. Ardal, Berit Lilje, Albin Sandelin, Torben Heick Jensen, Johannes Waage, Yun Chen, Søren Lykke-Andersen
Publikováno v:
Genes & Development. 30:1128-1134
Genes & Development 28: 2498–2517 (2014) While revisiting next-generation sequencing (NGS) data analyses from the above-mentioned article for another project, we discovered four unintentional errors. After correction of the errors, we reapplied the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39de8e3bd7160953a5b64faacd99fba1
https://doi.org/10.1101/gad.281881.116
https://doi.org/10.1101/gad.281881.116
Autor:
Anne Kruse Hollensen, Torben Heick Jensen, Britt Kidmose Ardal, Christian Kroun Damgaard, Søren Lykke-Andersen
Publikováno v:
Lykke-Andersen, S, Ardal, B K, Hollensen, A K, Damgaard, C K & Jensen, T H 2018, ' Box C/D snoRNP Autoregulation by a cis-Acting snoRNA in the NOP56 Pre-mRNA ', Molecular Cell, vol. 72, no. 1, pp. 99-111.e1-e5 . https://doi.org/10.1016/j.molcel.2018.08.017
Box C/D snoRNAs constitute a class of abundant noncoding RNAs that associate with common core proteins to form catalytic snoRNPs. Most of these operate in trans to assist the maturation of rRNAs by guiding and catalyzing the 2'-O-methylation of speci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5e5a407fb6137cfb348952de1dbb9cd
https://pure.au.dk/portal/da/publications/box-cd-snornp-autoregulation-by-a-cisacting-snorna-in-the-nop56-premrna(8815d7fc-ac42-4481-ad69-6b87940bb3fb).html
https://pure.au.dk/portal/da/publications/box-cd-snornp-autoregulation-by-a-cisacting-snorna-in-the-nop56-premrna(8815d7fc-ac42-4481-ad69-6b87940bb3fb).html