Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Søren E. Degn"'
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113869- (2024)
Summary: Autoimmune diseases strain healthcare systems worldwide as their incidence rises, and current treatments put patients at risk for infections. An increased understanding of autoimmune diseases is required to develop targeted therapies that do
Externí odkaz:
https://doaj.org/article/bc0022f38fed410292b004f22ca0f71c
Autor:
Cecilia Fahlquist-Hagert, Thomas R. Wittenborn, Ewa Terczyńska-Dyla, Kristian Savstrup Kastberg, Emily Yang, Alysa Nicole Rallistan, Quinton Raymond Markett, Gudrun Winther, Sofie Fonager, Lasse F. Voss, Mathias K. Pedersen, Nina van Campen, Alexey Ferapontov, Lisbeth Jensen, Jinrong Huang, John D. Nieland, Cees E. van der Poel, Johan Palmfeldt, Michael C. Carroll, Paul J. Utz, Yonglun Luo, Lin Lin, Søren E. Degn
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Circumstantial evidence suggests that B cells may instruct T cells to break tolerance. Here, to test this hypothesis, we used a murine model in which a single B cell clone precipitates an autoreactive response resembling systemic lupus eryth
Externí odkaz:
https://doaj.org/article/77b3e9364b6c4ef5993ede3e01fc8946
Autor:
Camilla Wibrand, Thomas R. Wittenborn, Lasse Frank Voss, Gudrun Winther, Lisbeth Jensen, Alexey Ferapontov, Sofie V. Fonager, Cecilia Fahlquist-Hagert, Søren E. Degn
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionMHC class II molecules are essential for appropriate immune responses against pathogens but are also implicated in pathological responses in autoimmune diseases and transplant rejection. Previous studies have shed light on the systemic co
Externí odkaz:
https://doaj.org/article/b133c1b93d4d46dd8350a1c4ec2d9740
Autor:
Lasse F. Voss, Amanda J. Howarth, Thomas R. Wittenborn, Sandra Hummelgaard, Kristian Juul-Madsen, Kristian S. Kastberg, Mathias K. Pedersen, Lisbeth Jensen, Anastasios D. Papanastasiou, Thomas Vorup-Jensen, Kathrin Weyer, Søren E. Degn
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
IntroductionMany autoimmune diseases are characterized by germinal center (GC)-derived, affinity-matured, class-switched autoantibodies, and strategies to block GC formation and progression are currently being explored clinically. However, extrafolli
Externí odkaz:
https://doaj.org/article/46d5f2474f894fdb93f2952297ceffaf
Autor:
Kenneth Green, Thomas R. Wittenborn, Cecilia Fahlquist-Hagert, Ewa Terczynska-Dyla, Nina van Campen, Lisbeth Jensen, Line Reinert, Rune Hartmann, Søren R. Paludan, Søren E. Degn
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Germinal centers (GCs) are induced microanatomical structures wherein B cells undergo affinity maturation to improve the quality of the antibody response. Although GCs are crucial to appropriate humoral responses to infectious challenges and vaccines
Externí odkaz:
https://doaj.org/article/77b01b2e96434180a61beee28b79cace
Autor:
Cees E. van der Poel, Goran Bajic, Charles W. Macaulay, Theo van den Broek, Christian D. Ellson, Gerben Bouma, Gabriel D. Victora, Søren E. Degn, Michael C. Carroll
Publikováno v:
Cell Reports, Vol 29, Iss 9, Pp 2745-2755.e4 (2019)
Summary: Follicular dendritic cells (FDCs), a rare and enigmatic stromal cell type in the B cell follicles of secondary lymphoid organs, store and present antigen to B cells. While essential for germinal center (GC) responses, their exact role during
Externí odkaz:
https://doaj.org/article/808ea57c369d473fa9c886315dd46bd7
Autor:
Martin Q. Rasmussen, Gitte Tindbæk, Morten Muhlig Nielsen, Camilla Merrild, Torben Steiniche, Jakob Skou Pedersen, Søren K. Moestrup, Søren E. Degn, Mette Madsen
Publikováno v:
Rasmussen, M Q, Tindbæk, G, Nielsen, M M, Merrild, C, Steiniche, T, Pedersen, J S, Moestrup, S K, Degn, S E & Madsen, M 2023, ' Epigenetic Silencing of LRP2 Is Associated with Dedifferentiation and Poor Survival in Multiple Solid Tumor Types ', Cancers, vol. 15, no. 6, 1830 . https://doi.org/10.3390/cancers15061830
Cancers; Volume 15; Issue 6; Pages: 1830
Cancers; Volume 15; Issue 6; Pages: 1830
More than 80% of human cancers originate in epithelial tissues. Loss of epithelial cell characteristics are hallmarks of tumor development. Receptor-mediated endocytosis is a key function of absorptive epithelial cells with importance for cellular an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea6df9d6a3bbc5d64d36b9a83e73a681
https://pure.au.dk/portal/da/publications/epigenetic-silencing-of-lrp2-is-associated-with-dedifferentiation-and-poor-survival-in-multiple-solid-tumor-types(0e72ff94-bd21-42d1-ba51-02f08ac5a0b7).html
https://pure.au.dk/portal/da/publications/epigenetic-silencing-of-lrp2-is-associated-with-dedifferentiation-and-poor-survival-in-multiple-solid-tumor-types(0e72ff94-bd21-42d1-ba51-02f08ac5a0b7).html
Autor:
Lasse F. Voss, Amanda J. Howarth, Thomas R. Wittenborn, Sandra Hummelgaard, Kristian Juul-Madsen, Kristian S. Kastberg, Mathias K. Pedersen, Lisbeth Jensen, Anastasios D. Papanastasiou, Thomas Vorup-Jensen, Kathrin Weyer, Søren E. Degn
Many autoimmune diseases are characterized by germinal center (GC) derived affinity-matured, class-switched autoantibodies. Strategies to block GC formation and progression are currently being explored clinically, however, extrafollicular responses m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c628024a870e4dabebd50509f515dcbd
https://doi.org/10.1101/2022.03.04.482991
https://doi.org/10.1101/2022.03.04.482991
Publikováno v:
Hagert, C F, Bohn, A B, Wittenborn, T R & Degn, S E 2020, ' Seeing the Confetti Colors in a New Light Utilizing Flow Cytometry and Imaging Flow Cytometry ', Cytometry. Part A, vol. 97, no. 8, pp. 811-823 . https://doi.org/10.1002/cyto.a.24032
Stochastic multicolor transgenic labeling systems, such as the Brainbow reporters, have emerged as powerful tools in lineage tracing experiments. Originally designed for large-scale mapping of neuronal projections in densely populated tissues, they h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::410348d6160db8d8f6b1ec46e8194444
https://doi.org/10.1002/cyto.a.24032
https://doi.org/10.1002/cyto.a.24032
Autor:
Søren E. Degn, Thomas Makatsoris, Dimitrios Chaniotis, Christos Aronis, Haralabos P. Kalofonos, Anastasios D Papanastasiou, Chaido Sirinian, Theodora Frantzi, Angelos Koutras
Publikováno v:
Genes
Sirinian, C, Papanastasiou, A D, Degn, S E, Frantzi, T, Aronis, C, Chaniotis, D, Makatsoris, T, Koutras, A & Kalofonos, H P 2021, ' Rank-c expression sensitizes er-negative, egfr-positive breast cancer cells to egfr-tyrosine kinase inhibitors (Tkis) ', Genes, vol. 12, no. 11, 1686 . https://doi.org/10.3390/genes12111686
Genes, Vol 12, Iss 1686, p 1686 (2021)
Sirinian, C, Papanastasiou, A D, Degn, S E, Frantzi, T, Aronis, C, Chaniotis, D, Makatsoris, T, Koutras, A & Kalofonos, H P 2021, ' Rank-c expression sensitizes er-negative, egfr-positive breast cancer cells to egfr-tyrosine kinase inhibitors (Tkis) ', Genes, vol. 12, no. 11, 1686 . https://doi.org/10.3390/genes12111686
Genes, Vol 12, Iss 1686, p 1686 (2021)
Background: We have previously shown that overexpression of RANK-c in ER-negative breast cancer cell lines attenuates aggressive properties of cancer cells, partially through a RANK-c/EGFR interaction. EGFR inhibition through TKIs in breast cancer ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::152644e5d6ff8e3d0d3a670202deb8a9
https://pubmed.ncbi.nlm.nih.gov/34828291
https://pubmed.ncbi.nlm.nih.gov/34828291