Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Søren Blok van Witteloostuijn"'
Autor:
Søren Blok van Witteloostuijn, Jacob Jelsing, Søren L. Pedersen, Grethe V. Jensen, Knud J. Jensen, Niels Vrang, Søren Roi Midtgaard, Louise S. Dalbøge, Gitte Hansen
Publikováno v:
Journal of Peptide Science. 23:845-854
Bariatric surgery is currently the most effective treatment of obesity, which has spurred an interest in developing pharmaceutical mimetics. It is thought that the marked body weight-lowering effects of bariatric surgery involve stimulated secretion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff9ba21c2bd13e620abd499de65966f5
https://doi.org/10.1002/psc.3048
https://doi.org/10.1002/psc.3048
Autor:
Knud J. Jensen, Søren Blok van Witteloostuijn, Søren L. Pedersen, Mikkel B. Thygesen, Manuel C. Martos-Maldonado, Jacob Jelsing, Niels Vrang, Kasper K. Sørensen, Pernille Wismann, Esben M. Bech
Publikováno v:
Journal of Medicinal Chemistry. 60:7434-7446
Noncovalent binding of biopharmaceuticals to human serum albumin protects against enzymatic degradation and renal clearance. Herein, we investigated the effect of mono- or divalent small-molecule albumin binders for half-life extension of peptides. F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0a0fb5a9e969193c0073c64a97f294d
https://doi.org/10.1021/acs.jmedchem.7b00787
https://doi.org/10.1021/acs.jmedchem.7b00787
Autor:
Søren Blok van Witteloostuijn, Søren L. Pedersen, Mikkel B. Thygesen, Esben M. Bech, Jacob Jelsing, Knud J. Jensen, Niels Vrang, Karin Mannerstedt, Pernille Wismann
Publikováno v:
Molecular Pharmaceutics. 14:193-205
Novel principles for optimizing the properties of peptide-based drugs are needed in order to leverage their full pharmacological potential. We present the design, synthesis, and evaluation of a library of neoglycolipidated glucagon-like peptide 1 (GL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92fff855fea81c7e76738fca4e81496b
https://doi.org/10.1021/acs.molpharmaceut.6b00787
https://doi.org/10.1021/acs.molpharmaceut.6b00787
Publikováno v:
ChemMedChem. 11:2474-2495
Peptides and proteins constitute a vast pool of excellent drug candidates. Evolution has equipped these molecules with superior drug-like properties such as high specificity and potency. However, native peptides and proteins suffer from an inadequate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e10603b565ca9c2bb7bf25a46a3449c8
https://doi.org/10.1002/cmdc.201600374
https://doi.org/10.1002/cmdc.201600374
Autor:
Jacob Jelsing, Louise S. Dalbøge, Knud J. Jensen, Birgitte Holst, Søren Blok van Witteloostuijn, Søren L. Pedersen, Niels Vrang, Kristoffer T. G. Rigbolt, Jakob E. Rasmussen
Publikováno v:
Journal of Peptide Science. 21:85-94
Neuromedin U (NMU) is a 25 amino acid peptide expressed and secreted in the brain and gastrointestinal tract. Data have shown that peripheral administration of human NMU decreases food intake and body weight and improves glucose tolerance in mice, su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a7b3cac04181bead27f8717c9b4f1e9
https://doi.org/10.1002/psc.2727
https://doi.org/10.1002/psc.2727
Publikováno v:
Journal of Endocrinology. 214:381-387
Recent data indicate that dipeptidyl peptidase 4 (DPP4) inhibitors have anti-inflammatory and β-cell-sparing effects in animal models of type 1 diabetes. To evaluate the effects of the DPP4 inhibitor linagliptin on β-cell mass and insulinitis, we e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::561930a41bba68b0c38c637dbbea7c75
https://doi.org/10.1530/joe-11-0479
https://doi.org/10.1530/joe-11-0479
Publikováno v:
Diabetes; Jun 2014 Supplement, pA450-A534, 85p, 2 Black and White Photographs, 1 Diagram, 13 Charts, 12 Graphs
Publikováno v:
Diabetes; Jun 2014 Supplement, pA495-A510, 16p, 3 Black and White Photographs, 2 Charts, 1 Graph