Combinatorial, additive and dose-dependent drug-microbiome associations

Autor: Forslund, SK, Chakaroun, R, Zimmermann-Kogadeeva, M, Markó, L, Aron-Wisnewsky, J, Nielsen, T, Moitinho-Silva, L, Schmidt, TSB, Falony, G, Vieira-Silva, S, Adriouch, S, Alves, RJ, Assmann, K, Bastard, J-P, Birkner, T, Caesar, R, Chilloux, J, Coelho, LP, Fezeu, L, Galleron, N, Helft, G, Isnard, R, Ji, B, Kuhn, M, Le Chatelier, E, Myridakis, A, Olsson, L, Pons, N, Prifti, E, Quinquis, B, Roume, H, Salem, J-E, Sokolovska, N, Tremaroli, V, Valles-Colomer, M, Lewinter, C, Søndertoft, NB, Pedersen, HK, Hansen, TH, Amouyal, C, Andersson Galijatovic, EA, Andreelli, F, Barthelemy, O, Batisse, J-P, Belda, E, Berland, M, Bittar, R, Blottière, H, Bosquet, F, Boubrit, R, Bourron, O, Camus, M, Cassuto, D, Ciangura, C, Collet, J-P, Dao, M-C, Djebbar, M, Doré, A, Engelbrechtsen, L, Fellahi, S, Fromentin, S, Galan, P, Gauguier, D, Giral, P, Hartemann, A, Hartmann, B, Holst, JJ, Hornbak, M, Hoyles, L, Hulot, J-S, Jaqueminet, S, Jørgensen, NR, Julienne, H, Justesen, J, Kammer, J, Krarup, N, Kerneis, M, Khemis, J, Kozlowski, R, Lejard, V, Levenez, F, Lucas-Martini, L, Massey, R, Martinez-Gili, L, Maziers, N, Medina-Stamminger, J, Montalescot, G, Moute, S, Neves, AL, Olanipekun, M, Le Pavin, LP, Poitou, C, Pousset, F, Pouzoulet, L, Rodriguez-Martinez, A, Rouault, C, Silvain, J, Svendstrup, M, Swartz, T, Vanduyvenboden, T, Vatier, C, Walther, S, Gøtze, JP, Køber, L, Vestergaard, H, Hansen, T, Zucker, J-D, Hercberg, S, Oppert, J-M, Letunic, I, Nielsen, J, Bäckhed, F, Ehrlich, SD, Dumas, M-E, Raes, J, Pedersen, O, Clément, K, Stumvoll, M, Bork, P, The MetaCardis Consortium (Hoyles, L.)

Publikováno v: Nature
Nature, 2021, 600 (7889), pp.500-505. ⟨10.1038/s41586-021-04177-9⟩

During the transition from a healthy state to cardiometabolic disease, patients become heavily medicated, which leads to an increasingly aberrant gut microbiome and serum metabolome, and complicates biomarker discovery1-5. Here, through integrated mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d63d45a4e7d6e8c270f49c7d2bf0ce1
http://edoc.mdc-berlin.de/21160/1/21160oa.pdf

Microbiome and metabolome features of the cardiometabolic disease spectrum.

Autor: Fromentin S; MetaGenoPolis, INRAe, AgroParisTech, Université Paris-Saclay, Paris, France., Forslund SK; Structural and Computational Biology, European Molecular Biology Laboratory, Heidelberg, Germany.; Experimental and Clinical Research Center, a cooperation of Charité-Universitätsmedizin and the Max-Delbrück Center, Berlin, Germany.; Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany.; Charité University Hospital, Berlin, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany., Chechi K; Section of Biomolecular Medicine, Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK.; School of Public Health, Faculty of Medicine, Imperial College London, Medical School Building, St. Mary's Hospital, London, UK.; Genomic and Environmental Medicine, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, UK., Aron-Wisnewsky J; Sorbonne Université, INSERM, Nutrition and obesities; systemic approaches (NutriOmics), Paris, France.; Assistance Publique Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Nutrition Department, Paris, France., Chakaroun R; Medical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany., Nielsen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Tremaroli V; The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Ji B; Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden., Prifti E; Sorbonne Université, INSERM, Nutrition and obesities; systemic approaches (NutriOmics), Paris, France.; Unité de modélisation mathématique et informatique des systèmes complexes, UMMISCO, Bondy, France., Myridakis A; Section of Biomolecular Medicine, Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK., Chilloux J; Section of Biomolecular Medicine, Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK., Andrikopoulos P; Section of Biomolecular Medicine, Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK.; Genomic and Environmental Medicine, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, UK., Fan Y; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Olanipekun MT; Section of Biomolecular Medicine, Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK.; Genomic and Environmental Medicine, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, UK., Alves R; Structural and Computational Biology, European Molecular Biology Laboratory, Heidelberg, Germany., Adiouch S; Sorbonne Université, INSERM, Nutrition and obesities; systemic approaches (NutriOmics), Paris, France., Bar N; Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel.; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Talmor-Barkan Y; Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel.; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.; Department of Cardiology, Rabin Medical Center, Petah Tikva, Israel.; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel., Belda E; Sorbonne Université, INSERM, Nutrition and obesities; systemic approaches (NutriOmics), Paris, France.; Institute of Cardiometabolism and Nutrition, Integromics Unit, Paris, France.; Integrative Phenomics, Paris, France., Caesar R; The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Coelho LP; Structural and Computational Biology, European Molecular Biology Laboratory, Heidelberg, Germany., Falony G; Laboratory of Molecular Bacteriology, Department of Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium.; Center for Microbiology, VIB, Leuven, Belgium., Fellahi S; Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Henri Mondor, Département de biochimie-pharmacologie-biologie moléculaire-génétique médicale, Créteil, France., Galan P; MetaGenoPolis, INRAe, AgroParisTech, Université Paris-Saclay, Paris, France., Galleron N; MetaGenoPolis, INRAe, AgroParisTech, Université Paris-Saclay, Paris, France., Helft G; Assistance Publique Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Cardiology Department, Paris, France., Hoyles L; Section of Biomolecular Medicine, Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK.; Nottingham Trent University, Department of Bioscience, School of Science and Technology, Nottingham, UK., Isnard R; Assistance Publique Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Cardiology Department, Paris, France., Le Chatelier E; MetaGenoPolis, INRAe, AgroParisTech, Université Paris-Saclay, Paris, France., Julienne H; MetaGenoPolis, INRAe, AgroParisTech, Université Paris-Saclay, Paris, France., Olsson L; The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Pedersen HK; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Pons N; MetaGenoPolis, INRAe, AgroParisTech, Université Paris-Saclay, Paris, France., Quinquis B; MetaGenoPolis, INRAe, AgroParisTech, Université Paris-Saclay, Paris, France., Rouault C; Sorbonne Université, INSERM, Nutrition and obesities; systemic approaches (NutriOmics), Paris, France., Roume H; MetaGenoPolis, INRAe, AgroParisTech, Université Paris-Saclay, Paris, France., Salem JE; AP-HP, Pitié-Salpêtrière Hospital, Department of Pharmacology, UNICO Cardio-oncology Program, CIC-1421; INSERM, Sorbonne Université, Paris, France., Schmidt TSB; Structural and Computational Biology, European Molecular Biology Laboratory, Heidelberg, Germany., Vieira-Silva S; Laboratory of Molecular Bacteriology, Department of Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium.; Center for Microbiology, VIB, Leuven, Belgium., Li P; Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden., Zimmermann-Kogadeeva M; Structural and Computational Biology, European Molecular Biology Laboratory, Heidelberg, Germany., Lewinter C; Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark., Søndertoft NB; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Hansen TH; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Gauguier D; Université de Paris, INSERM UMR 1124, Paris, France., Gøtze JP; Department of Clinical Biochemetry, Rigshopitalet, University of Copenhagen, Copenhagen, Denmark., Køber L; Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark., Kornowski R; Department of Cardiology, Rabin Medical Center, Petah Tikva, Israel., Vestergaard H; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Medicine, Bornholms Hospital, Rønne, Denmark., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Zucker JD; Sorbonne Université, INSERM, Nutrition and obesities; systemic approaches (NutriOmics), Paris, France.; Unité de modélisation mathématique et informatique des systèmes complexes, UMMISCO, Bondy, France., Hercberg S; Sorbonne Paris Cité Epidemiology and Statistics Research Centre (CRESS), U1153 Inserm, U1125, Inra, Cnam, University of Paris 13, Nutritional Epidemiology Research Team (EREN), Bobigny, France., Letunic I; Biobyte Solutions GmbH, Heidelberg, Germany., Bäckhed F; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Oppert JM; Assistance Publique Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Nutrition Department, Paris, France., Nielsen J; Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden., Raes J; Laboratory of Molecular Bacteriology, Department of Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium.; Center for Microbiology, VIB, Leuven, Belgium., Bork P; Structural and Computational Biology, European Molecular Biology Laboratory, Heidelberg, Germany., Stumvoll M; Medical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany., Segal E; Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel.; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Clément K; Sorbonne Université, INSERM, Nutrition and obesities; systemic approaches (NutriOmics), Paris, France. karine.clement@inserm.fr.; Assistance Publique Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Nutrition Department, Paris, France. karine.clement@inserm.fr., Dumas ME; Section of Biomolecular Medicine, Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK. m.dumas@imperial.ac.uk.; Genomic and Environmental Medicine, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, UK. m.dumas@imperial.ac.uk.; European Genomics Institute for Diabetes, UMR1283/8199 INSERM, CNRS, Institut Pasteur de Lille, Lille University Hospital, University of Lille, Lille, France. m.dumas@imperial.ac.uk., Ehrlich SD; MetaGenoPolis, INRAe, AgroParisTech, Université Paris-Saclay, Paris, France. s.ehrlich@ucl.ac.uk.; Department of Clinical and Movement Neurosciences, University College London, London, UK. s.ehrlich@ucl.ac.uk., Pedersen O; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. oluf@sund.ku.dk.

Publikováno v: Nature medicine [Nat Med] 2022 Feb; Vol. 28 (2), pp. 303-314. Date of Electronic Publication: 2022 Feb 17.

The intestinal microbiome is a co-determinant of the postprandial plasma glucose response.

Autor: Søndertoft NB; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Vogt JK; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Arumugam M; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Kristensen M; Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark., Gøbel RJ; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Fan Y; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Lyu L; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Bahl MI; National Food Institute, Technical University of Denmark, Lyngby, Denmark., Eriksen C; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kgs. Lyngby, Denmark., Ängquist L; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Frøkiær H; Department of Veterinary Disease Biology, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark., Hansen TH; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Brix S; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kgs. Lyngby, Denmark., Nielsen HB; Clinical-Microbiomics A/S, Copenhagen, Denmark., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Vestergaard H; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Gupta R; Department of Health Technology, Technical University of Denmark, Lyngby, Denmark., Licht TR; National Food Institute, Technical University of Denmark, Lyngby, Denmark., Lauritzen L; Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark., Pedersen O; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.

Publikováno v: PloS one [PLoS One] 2020 Sep 18; Vol. 15 (9), pp. e0238648. Date of Electronic Publication: 2020 Sep 18 (Print Publication: 2020).

A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults.

Autor: Hansen LBS; Department of Bio and Health Informatics, Technical University of Denmark, DK-2800, Kgs. Lyngby, Denmark., Roager HM; National Food Institute, Technical University of Denmark, DK-2800, Kgs. Lyngby, Denmark.; Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, DK-1958, Frederiksberg, Denmark., Søndertoft NB; The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, DK-2200, Copenhagen, Denmark., Gøbel RJ; The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, DK-2200, Copenhagen, Denmark., Kristensen M; Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, DK-1958, Frederiksberg, Denmark., Vallès-Colomer M; Department of Microbiology and Immunology, KU Leuven-University of Leuven, Rega Institute, 3000, Leuven, Belgium.; VIB, Center for Microbiology, 3000, Leuven, Belgium., Vieira-Silva S; Department of Microbiology and Immunology, KU Leuven-University of Leuven, Rega Institute, 3000, Leuven, Belgium.; VIB, Center for Microbiology, 3000, Leuven, Belgium., Ibrügger S; Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, DK-1958, Frederiksberg, Denmark., Lind MV; Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, DK-1958, Frederiksberg, Denmark., Mærkedahl RB; Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, DK-1958, Frederiksberg, Denmark.; Department of Veterinary Disease Biology, Faculty of Science, University of Copenhagen, DK-1958, Frederiksberg, Denmark., Bahl MI; National Food Institute, Technical University of Denmark, DK-2800, Kgs. Lyngby, Denmark., Madsen ML; The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, DK-2200, Copenhagen, Denmark., Havelund J; Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK-5230, Odense, Denmark., Falony G; Department of Microbiology and Immunology, KU Leuven-University of Leuven, Rega Institute, 3000, Leuven, Belgium.; VIB, Center for Microbiology, 3000, Leuven, Belgium., Tetens I; Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, DK-1958, Frederiksberg, Denmark., Nielsen T; The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, DK-2200, Copenhagen, Denmark., Allin KH; The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, DK-2200, Copenhagen, Denmark., Frandsen HL; National Food Institute, Technical University of Denmark, DK-2800, Kgs. Lyngby, Denmark., Hartmann B; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, DK-2200, Denmark., Holst JJ; The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, DK-2200, Copenhagen, Denmark., Sparholt MH; Department of Radiology, Bispebjerg Hospital, Copenhagen, DK-2400, Denmark., Holck J; Department of Chemical and Biochemical Engineering, Technical University of Denmark, DK-2800, Kgs. Lyngby, Denmark., Blennow A; Department of Plant and Environmental Sciences, University of Copenhagen, DK-1958, Frederiksberg, Denmark., Moll JM; Department of Biotechnology and Biomedicine, Technical University of Denmark, DK-2800, Kgs. Lyngby, Denmark., Meyer AS; Department of Chemical and Biochemical Engineering, Technical University of Denmark, DK-2800, Kgs. Lyngby, Denmark., Hoppe C; National Food Institute, Technical University of Denmark, DK-2800, Kgs. Lyngby, Denmark., Poulsen JH; Department of Clinical Biochemistry, Copenhagen University Hospital Hvidovre, DK-2650, Hvidovre, Denmark., Carvalho V; National Food Institute, Technical University of Denmark, DK-2800, Kgs. Lyngby, Denmark., Sagnelli D; Department of Plant and Environmental Sciences, University of Copenhagen, DK-1958, Frederiksberg, Denmark., Dalgaard MD; Department of Biotechnology and Biomedicine, Technical University of Denmark, DK-2800, Kgs. Lyngby, Denmark., Christensen AF; Department of Radiology, Bispebjerg Hospital, Copenhagen, DK-2400, Denmark., Lydolph MC; Department of Autoimmunology & Biomarkers, Statens Serum Institut, DK-2300, Copenhagen, Denmark., Ross AB; Department of Biology and Biological Engineering, Chalmers University of Technology, 412 96, Gothenburg, Sweden., Villas-Bôas S; School of Biological Sciences, The University of Auckland, 1010, Auckland, New Zealand., Brix S; Department of Biotechnology and Biomedicine, Technical University of Denmark, DK-2800, Kgs. Lyngby, Denmark., Sicheritz-Pontén T; Department of Bio and Health Informatics, Technical University of Denmark, DK-2800, Kgs. Lyngby, Denmark., Buschard K; Bartholin Institute, Rigshospitalet, DK-2200, Copenhagen, Denmark., Linneberg A; Research Centre for Prevention and Health, The Capital Region of Denmark, DK-2000, Frederiksberg, Denmark., Rumessen JJ; Research Unit and Department of Gastroenterology, Herlev and Gentofte Hospital, the Capital Region of Denmark, 2730, Herlev, Denmark., Ekstrøm CT; Biostatistics, Department of Public Health, University of Copenhagen, DK-1014, Copenhagen, Denmark., Ritz C; Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, DK-1958, Frederiksberg, Denmark., Kristiansen K; Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, DK-2100, Copenhagen, Denmark., Nielsen HB; Clinical-Microbiomics A/S, DK-2200, Copenhagen, Denmark., Vestergaard H; The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, DK-2200, Copenhagen, Denmark., Færgeman NJ; Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK-5230, Odense, Denmark., Raes J; Department of Microbiology and Immunology, KU Leuven-University of Leuven, Rega Institute, 3000, Leuven, Belgium.; VIB, Center for Microbiology, 3000, Leuven, Belgium., Frøkiær H; Department of Veterinary Disease Biology, Faculty of Science, University of Copenhagen, DK-1958, Frederiksberg, Denmark., Hansen T; The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, DK-2200, Copenhagen, Denmark., Lauritzen L; Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, DK-1958, Frederiksberg, Denmark., Gupta R; Department of Bio and Health Informatics, Technical University of Denmark, DK-2800, Kgs. Lyngby, Denmark. ramneek@bioinformatics.dtu.dk., Licht TR; National Food Institute, Technical University of Denmark, DK-2800, Kgs. Lyngby, Denmark. trli@food.dtu.dk., Pedersen O; The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, DK-2200, Copenhagen, Denmark. oluf@sund.ku.dk.

Publikováno v: Nature communications [Nat Commun] 2018 Nov 13; Vol. 9 (1), pp. 4630. Date of Electronic Publication: 2018 Nov 13.