Výsledky vyhledávání - "Sören T. Eichhorst"

P60-c-src suppresses apoptosis through inhibition of caspase 8 activation in hepatoma cells, but not in primary hepatocytes

Autor: Wolfgang E. Thasler, Alexander L. Gerbes, Christiane Bruns, Sören T. Eichhorst, N. Sonuc, Peter Camaj, Enrico N. De Toni, Burkhard Göke, Christian Kuntzen, S. Mucha

Publikováno v: Journal of Hepatology. 46:682-691

Background/Aims Failure to induce apoptosis triggered by members of the death receptor family has been described in hepatocellular carcinoma (HCC) and sensitization of malignant cells to pro-apoptotic molecules such as TRAIL has been proposed as an a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ef8a34b572d14dbfd6ba7f73a672e5a
https://doi.org/10.1016/j.jhep.2006.10.010

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IL-22 is increased in active Crohn’s disease and promotes proinflammatory gene expression and intestinal epithelial cell migration

Autor: Stephan Brand, Andreas Marquardt, Helmut M. Diepolder, Julia Dambacher, Thomas Ochsenkühn, Julia Seiderer, Torsten Olszak, Florian Beigel, Stéphane Leclair, Jan-Michel Otte, Kathrin Zitzmann, Karin A. Herrmann, Christoph J. Auernhammer, Wolfgang Jagla, Andreas Popp, Sören T. Eichhorst, Burkhard Göke

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 290:G827-G838

IL-22 is produced by activated T cells and signals through a receptor complex consisting of IL-22R1 and IL-10R2. The aim of this study was to analyze IL-22 receptor expression, signal transduction, and specific biological functions of this cytokine s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22f596094b337655c672cc9fabb8f2e0
https://doi.org/10.1152/ajpgi.00513.2005

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Inhibition of c-Jun-N-terminal-Kinase Sensitizes Tumor Cells to CD95-Induced Apoptosis and Induces G2/M Cell Cycle Arrest

Autor: Christian Kuntzen, C. Opelz, Alexander L. Gerbes, Enrico N. De Toni, Sören T. Eichhorst, S. Mucha, N. Sonuc

Publikováno v: Cancer Research. 65:6780-6788

Loss of susceptibility to apoptosis signals is a crucial step in carcinogenesis. Therefore, sensitization of tumor cells to apoptosis is a promising therapeutic strategy. c-Jun-N-terminal-kinases (JNK) have been implicated in stress-induced apoptosis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::388f026cba49b34a1cf10757e36d7d10
https://doi.org/10.1158/0008-5472.can-04-2618

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DRO1, a Gene Down-regulated by Oncogenes, Mediates Growth Inhibition in Colon and Pancreatic Cancer Cells

Autor: Gang Hu, Burkhard Göke, Georg J. Arnold, Frank T. Kolligs, Dagmar C. Kress, Sören T. Eichhorst, Sebastian Baehs, Eric R. Fearon, Claudia Jäger, Guido T. Bommer, Thomas Fröhlich, Thomas Brabletz, Eva Maria Dürr

Publikováno v: Journal of Biological Chemistry. 280:7962-7975

Neoplastic progression in human tissues appears to be paralleled by a series of genetic and epigenetic alterations. In human colorectal cancers, defect Wnt/beta-catenin/T-cell factor and RAS/RAF signaling pathways have a major contributing role in tu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbabe0c8ba0a8bfa8a5ef5e1424a5624
https://doi.org/10.1074/jbc.m412593200

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Modulation of apoptosis as a target for liver disease

Autor: Sören T. Eichhorst

Publikováno v: Expert Opinion on Therapeutic Targets. 9:83-99

Apoptosis mediated via extrinsic or intrinsic pathways is essential for maintaining cellular homeostasis in the liver. The extrinsic pathway is triggered from the cell surface by engagement of death receptors as CD95, TRAIL (TNF-related apoptosis ind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e2c1fa3774dce06bcca53bca2e58afa
https://doi.org/10.1517/14728222.9.1.83

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Upregulation of Major Histocompatibility Complex Class I on Liver Cells by Hepatitis C Virus Core Protein via p53 and TAP1 Impairs Natural Killer Cell Cytotoxicity

Autor: Barbara Seliger, Peter H. Krammer, Jens Encke, Christine S. Falk, K Herzer, Axel Ulsenheimer, Sören T. Eichhorst

Publikováno v: Journal of Virology. 77:8299-8309

The mechanisms of immune evasion and the role of the early immune response in chronic infection caused by hepatitis C virus (HCV) are still unclear. Here, we present evidence for a cascade of molecular events that the virus initiates to subvert the i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ca3266afef09bedafa9478728f20376
https://doi.org/10.1128/jvi.77.15.8299-8309.2003

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Restoration of p53 expression sensitizes human papillomavirus type 16 immortalized human keratinocytes to CD95-mediated apoptosis

Autor: Adriana Aguilar-Lemarroy, Patricio Gariglio, Noel J. Whitaker, Frank Rösl, Harald zur Hausen, Peter H. Krammer, Sören T. Eichhorst

Publikováno v: Oncogene. 21:165-175

To understand the function of the individual oncogenes of HPV16 in modulating the cellular response to apoptogenic signals, we used human keratinocytes immortalized with either E6, E7 or E6/E7 oncoproteins as model system. Applying CD95 antibodies or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aac351e9dcaa3758a63676d2331b71a
https://doi.org/10.1038/sj.onc.1204979

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Ethanol-Induced Apoptosis in Hepatoma Cells Proceeds via Intracellular Ca2+ Elevation, Activation of TLCK-Sensitive Proteases, and Cytochrome c Release

Autor: Nobuaki Nakayama, Peter H. Krammer, Sören T. Eichhorst, Martina Müller

Publikováno v: Experimental Cell Research. 269:202-213

Ethanol is known to induce apoptosis in hepatocytes. However, intracellular signaling events of ethanol-induced death are still only partially understood. We studied such processes in ethanol-induced apoptosis in HepG2 cells as a model system for hum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbcbbf632be22dc73d5c272b2f9cdbdf
https://doi.org/10.1006/excr.2001.5319

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