Loss of PINK1 impairs stress-induced autophagy and cell survival.

Autor: Dajana Parganlija, Michael Klinkenberg, Jorge Domínguez-Bautista, Miriam Hetzel, Suzana Gispert, Marthe A Chimi, Stefan Dröse, Sören Mai, Ulrich Brandt, Georg Auburger, Marina Jendrach

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e95288 (2014)

The mitochondrial kinase PINK1 and the ubiquitin ligase Parkin are participating in quality control after CCCP- or ROS-induced mitochondrial damage, and their dysfunction is associated with the development and progression of Parkinson's disease. Furt

Externí odkaz: https://doaj.org/article/2babc727b13d4a70af9e4685b395312f

A New Link to Mitochondrial Impairment in Tauopathies

Autor: Walter E. Müller, Winfried Haase, Kathrin Schulz, Virginie Rhein, Sören Mai, Anne Eckert, Marina Jendrach, Andreas S. Reichert, Kristina Leuner

Publikováno v: Molecular Neurobiology. 46:205-216

Tauopathies like the "frontotemporal dementia with Parkinsonism linked to chromosome 17" (FTDP-17) are characterized by an aberrant accumulation of intracellular neurofibrillary tangles composed of hyperphosphorylated tau. For FTDP-17, a pathogenic t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2ed651e54904446b04465c2f2dbdfcb
https://doi.org/10.1007/s12035-012-8308-3

Short- and long-term alterations of mitochondrial morphology, dynamics and mtDNA after transient oxidative stress

Autor: Jürgen Bereiter-Hahn, Marina Jendrach, Sören Mai, Sandra Pohl, Monika Vöth

Publikováno v: Mitochondrion. 8:293-304

Cells are exposed during their life span to fluctuating levels of reactive oxygen species (ROS). To investigate the effects of a single ROS boost in vitro, human endothelial cells (HUVEC) were treated with one short-term dose of hydrogen peroxide. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::546646ff06cd5ce801936e44b10a5bfa
https://doi.org/10.1016/j.mito.2008.06.001

Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation

Autor: Michael Willem, Sören Mai, Angelo Occhipinti, Stephan Dröse, Schamim H. Eckert, Ulrich Brandt, Carola Schiller, Richard D. Palmiter, Gunter P. Eckert, Ilka Wittig, Shane E. Kruse, Tanja Schütt, Kristina Leuner, Christian Haass, Christopher Kurz, Walter E. Müller, Marina Jendrach, Andreas S. Reichert

Publikováno v: Antioxidants & Redox Signaling, 16, 1421-33
Antioxidants & redox signaling 16(12), 1421-1433 (2012). doi:10.1089/ars.2011.4173
Antioxidants & Redox Signaling, 16, 12, pp. 1421-33

Item does not contain fulltext AIMS: Intracellular amyloid beta (Abeta) oligomers and extracellular Abeta plaques are key players in the progression of sporadic Alzheimer's disease (AD). Still, the molecular signals triggering Abeta production are la

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::740a4dd8a5748d77110e784a234adbea
http://hdl.handle.net/2066/108688

Structural implications of mitochondrial dynamics

Autor: Sören Mai, Marina Jendrach, Jürgen Bereiter-Hahn, Monika Vöth

Publikováno v: Biotechnology journal. 3(6)

Mitochondrial components are continuously distributed throughout the whole chondriome of a cell by fusion and fission. Thus, a single mitochondrion represents a transient fraction of the chondriome. Mitochondrial dynamics are responsible for intracel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::531f613b3ce9301f0ccb3507af7c85e5
https://pubmed.ncbi.nlm.nih.gov/18512869