Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Sören Boller"'
Autor:
Marc Bayer, Sören Boller, Senthilkumar Ramamoothy, Nikolay Zolotarev, Pierre Cauchy, Norimasa Iwanami, Gerhard Mittler, Thomas Boehm, Rudolf Grosschedl
Publikováno v:
Genes and Development
Transcription factor EBF1 (early B cell factor 1) acts as a key regulator of B cell specification. The transcriptional network in which EBF1 operates has been extensively studied; however, the regulation of EBF1 function remains poorly defined. By ma
Autor:
Sören Boller, Tonya Wallace, Christopher E. Coletta, Dimitra Sarantopoulou, Julia McKelvey, Yulan Piao, Luigi Ferrucci, Cuong Q. Nguyen, Sampath Arepalli, Benjamin D. Shapiro, Christopher A. Dunn, Mary Kaileh, Ranjan Sen, Dena G. Hernandez, Linda Zukley, Nan-ping Weng, Arsun Bektas, Alexis Battle, Roshni Roy, Ann Zenobia Moore, Senthilkumar Ramamoorthy, Supriyo De, Toshiko Tanaka, Kevin G. Becker, Rudolf Grosschedl, Amit Singh, William H. Wood, Jaekwan Kim, Jyoti Misra Sen, Robert P. Wersto
Publikováno v:
Immunity
Epigenetic reprogramming underlies specification of immune cell lineages, but patterns that uniquely define immune cell types and the mechanisms by which they are established remain unclear. Here, we identified lineage-specific DNA methylation signat
Autor:
Sören Boller, Kohei Kometani, Joy Edwards-Hicks, Erika L. Pearce, Senthilkumar Ramamoorthy, Marc Bayer, Dominic Grün, Ramon Klein-Geltink, Rudolf Grosschedl, Josip S. Herman, Rui Li, Haribaskar Ramachandran
Publikováno v:
Genes and Development
Genes Dev
Genes Dev
EBF1 and PAX5 mutations are associated with the development of B progenitor acute lymphoblastic leukemia (B-ALL) in humans. To understand the molecular networks driving leukemia in the Ebf1+/−Pax5+/− (dHet) mouse model for B-ALL, we interrogated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b93649a9311e08c51a69ca133c98217
https://hdl.handle.net/21.11116/0000-0007-62F9-221.11116/0000-0007-62F7-4
https://hdl.handle.net/21.11116/0000-0007-62F9-221.11116/0000-0007-62F7-4
Publikováno v:
Trends in Genetics
Hematopoiesis is regulated by signals from the microenvironment, transcription factor networks, and changes of the epigenetic landscape. Transcription factors interact with and shape chromatin to allow for lineage- and cell type-specific changes in g
Autor:
Sören Boller, Rudolf Grosschedl, Lukas Chavez, Rui Li, Senthilkumar Ramamoorthy, Pierre Cauchy
Publikováno v:
Genes and Development
B-cell fate determination requires the action of transcription factors that operate in a regulatory network to activate B-lineage genes and repress lineage-inappropriate genes. However, the dynamics and hierarchy of events in B-cell programming remai
Autor:
Rudolf Grosschedl, Duygu Akbas, Dirk Schübeler, Robert Nechanitzky, Rabih Murr, Senthilkumar Ramamoorthy, Sören Boller, Lukas Burger
Publikováno v:
Immunity
Immunity, Vol. 44, No 3 (2016) pp. 527-541
Immunity, Vol. 44, No 3 (2016) pp. 527-541
Lymphopoiesis requires the activation of lineage-specific genes embedded in naive, inaccessible chromatin or in primed, accessible chromatin. The mechanisms responsible for de novo gain of chromatin accessibility, known as "pioneer" function, remain
Autor:
Sören Boller, Rudolf Grosschedl
Publikováno v:
Immunological Reviews
During the last decades, many studies have investigated the transcriptional and epigenetic regulation of lineage decision in the hematopoietic system. These efforts led to a model in which extrinsic signals and intrinsic cues establish a permissive c
Autor:
Elizabeth M. Mandel, Ildiko Györy, Rudolf Grosschedl, Robert Nechanitzky, Sören Boller, Edison T. Liu, Sebastian Pott
Publikováno v:
Genes and Development
The transcription factor Ebf1 is an important determinant of early B lymphopoiesis. To gain insight into the functions of Ebf1 at distinct stages of differentiation, we conditionally inactivated Ebf1. We found that Ebf1 is required for the proliferat
Publikováno v:
Experimental Hematology. 53:S89
Autor:
Sameena Iqbal, Derville O’Shea, Cheng Yuan Yang, Elia Stupka, Jun Wang, Jude Fitzgibbon, Andrew Davies, Jacek Marzec, Richard J. Byers, Charles A. Mein, András Matolcsy, David Wrench, Sören Boller, Monika Bozek, Andrew Norton, T. Andrew Lister, Maria Calaminici, John G. Gribben, Georg Lenz, Silvia Montoto, Rudolf Grosschedl, Kiran Tawana, Csaba Bödör, Yuhong Fan, Claude Chelala, Janet Matthews, Nikolay Popov, Davide Cittaro, Ciaran O'Riain, Jessica Okosun, Shamzah Araf, Emanuela Carlotti, Chenyi Pan, Charles H. Lawrie
Publikováno v:
Nature Genetics
Nature genetics
Nature genetics
Follicular lymphoma is an incurable malignancy, with transformation to an aggressive subtype representing a critical event during disease progression. Here we performed whole-genome or whole-exome sequencing on 10 follicular lymphoma-transformed foll
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::723250d075dda41fc64e53297c71969a
https://hdl.handle.net/11858/00-001M-0000-002B-8883-D
https://hdl.handle.net/11858/00-001M-0000-002B-8883-D