Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression.

Autor: Võsa U; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. urmo.vosa@gmail.com.; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia. urmo.vosa@gmail.com., Claringbould A; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. anniqueclaringbould@gmail.com.; Oncode Institute, Amsterdam, the Netherlands. anniqueclaringbould@gmail.com.; Structural & Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany. anniqueclaringbould@gmail.com., Westra HJ; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Oncode Institute, Amsterdam, the Netherlands., Bonder MJ; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany., Deelen P; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Oncode Institute, Amsterdam, the Netherlands.; Genomics Coordination Center, University Medical Centre Groningen, Groningen, the Netherlands.; Department of Genetics, University Medical Centre Utrecht, Utrecht, the Netherlands., Zeng B; School of Biological Sciences, Georgia Tech, Atlanta, GA, USA., Kirsten H; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany., Saha A; Department of Computer Science, Johns Hopkins University, Baltimore, MD, USA., Kreuzhuber R; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.; NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom., Yazar S; Garvan Institute of Medical Research, Garvan-Weizmann Centre for Cellular Genomics, Sydney, New South Wales, Australia., Brugge H; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Oncode Institute, Amsterdam, the Netherlands., Oelen R; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Oncode Institute, Amsterdam, the Netherlands., de Vries DH; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Oncode Institute, Amsterdam, the Netherlands., van der Wijst MGP; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Oncode Institute, Amsterdam, the Netherlands., Kasela S; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Pervjakova N; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Alves I; Computational Biology, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.; L'institut du thorax, Université de Nantes, CHU Nantes, INSERM, CNRS, Nantes, France., Favé MJ; Computational Biology, Ontario Institute for Cancer Research, Toronto, Ontario, Canada., Agbessi M; Computational Biology, Ontario Institute for Cancer Research, Toronto, Ontario, Canada., Christiansen MW; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA., Jansen R; Department of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Public Health Research Institute and Amsterdam Neuroscience, Amsterdam, the Netherlands., Seppälä I; Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Tong L; Department of Public Health Sciences, University of Chicago, Chicago, IL, USA., Teumer A; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany., Schramm K; Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Department of Medicine I, University Hospital Munich, Ludwig Maximilian's University, Munich, Germany., Hemani G; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom., Verlouw J; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands., Yaghootkar H; Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, United Kingdom.; School of Life Sciences, College of Liberal Arts and Science, University of Westminster, London, United Kingdom.; Division of Medical Sciences, Department of Health Sciences, Luleå University of Technology, Luleå, Sweden., Sönmez Flitman R; Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Brown A; Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland.; Population Health and Genomics, University of Dundee, Dundee, United Kingdom., Kukushkina V; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Kalnapenkis A; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Rüeger S; Lausanne University Hospital, Lausanne, Switzerland., Porcu E; Lausanne University Hospital, Lausanne, Switzerland., Kronberg J; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Kettunen J; Computational Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland.; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.; Biocenter Oulu, University of Oulu, Oulu, Finland.; Finnish Institute for Health and Welfare, Helsinki, Finland., Lee B; Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore., Zhang F; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., Qi T; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., Hernandez JA; Garvan Institute of Medical Research, Garvan-Weizmann Centre for Cellular Genomics, Sydney, New South Wales, Australia., Arindrarto W; Leiden University Medical Center, Leiden, the Netherlands., Beutner F; Heart Center Leipzig, Universität Leipzig, Leipzig, Germany., Dmitrieva J; Unit of Animal Genomics, WELBIO, GIGA-R & Faculty of Veterinary Medicine, University of Liège, Liège, Belgium., Elansary M; Unit of Animal Genomics, WELBIO, GIGA-R & Faculty of Veterinary Medicine, University of Liège, Liège, Belgium., Fairfax BP; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Georges M; Unit of Animal Genomics, WELBIO, GIGA-R & Faculty of Veterinary Medicine, University of Liège, Liège, Belgium., Heijmans BT; Leiden University Medical Center, Leiden, the Netherlands., Hewitt AW; Menzies Institute for Medical Research, School of Medicine, University of Tasmania, Hobart, Tasmania, Australia.; Centre for Eye Research Australia, Department of Surgery, University of Melbourne, Melbourne, Victoria, Australia., Kähönen M; Department of Clinical Physiology, Tampere University Hospital and Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Kim Y; Department of Computer Science, Johns Hopkins University, Baltimore, MD, USA.; Genetics and Genomic Science Department, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Knight JC; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Kovacs P; IFB Adiposity Diseases, Universität Leipzig, Leipzig, Germany., Krohn K; Interdisciplinary Center for Clinical Research, Faculty of Medicine, Universität Leipzig, Leipzig, Germany., Li S; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Genomics Coordination Center, University Medical Centre Groningen, Groningen, the Netherlands., Loeffler M; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany., Marigorta UM; School of Biological Sciences, Georgia Tech, Atlanta, GA, USA.; Integrative Genomics Lab, CIC bioGUNE, Basque Research and Technology Alliance (BRTA), Bizkaia Science and Technology Park, Derio, Spain.; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain., Mei H; Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, the Netherlands., Momozawa Y; Unit of Animal Genomics, WELBIO, GIGA-R & Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.; Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan., Müller-Nurasyid M; Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Department of Medicine I, University Hospital Munich, Ludwig Maximilian's University, Munich, Germany.; IBE, Faculty of Medicine, LMU Munich, Munich, Germany., Nauck M; DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany., Nivard MG; Department of Biological Psychology, Faculty of Behaviour and Movement Sciences, Vrije Universiteit, Amsterdam, the Netherlands., Penninx BWJH; Department of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Public Health Research Institute and Amsterdam Neuroscience, Amsterdam, the Netherlands., Pritchard JK; Department of Biology, Stanford University, Stanford, CA, USA.; Department of Genetics, Stanford University, Stanford, CA, USA., Raitakari OT; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland., Rotzschke O; Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore., Slagboom EP; Leiden University Medical Center, Leiden, the Netherlands., Stehouwer CDA; Department of Internal Medicine and School for Cardiovascular Diseases (CARIM), Maastricht University Medical Center, Maastricht, the Netherlands., Stumvoll M; Department of Medicine, Universität Leipzig, Leipzig, Germany., Sullivan P; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., 't Hoen PAC; Center for Molecular and Biomolecular Informatics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center Nijmegen, Nijmegen, the Netherlands., Thiery J; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.; Institute for Laboratory Medicine, LIFE-Leipzig Research Center for Civilization Diseases, Universität Leipzig, Leipzig, Germany., Tönjes A; Department of Medicine, Universität Leipzig, Leipzig, Germany., van Dongen J; Netherlands Twin Register, Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam Public Health Research Institute and Amsterdam Neuroscience, Amsterdam, the Netherlands., van Iterson M; Leiden University Medical Center, Leiden, the Netherlands., Veldink JH; UMC Utrecht Brain Center, University Medical Center Utrecht, Department of Neurology, Utrecht University, Utrecht, the Netherlands., Völker U; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany., Warmerdam R; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Oncode Institute, Amsterdam, the Netherlands., Wijmenga C; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Swertz M; Genomics Coordination Center, University Medical Centre Groningen, Groningen, the Netherlands., Andiappan A; Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore., Montgomery GW; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., Ripatti S; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.; Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Perola M; National Institute for Health and Welfare, University of Helsinki, Helsinki, Finland., Kutalik Z; Center for Primary Care and Public Health, University of Lausanne, Lausanne, Switzerland., Dermitzakis E; Swiss Institute of Bioinformatics, Lausanne, Switzerland.; Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland.; Institute of Genetics and Genomics in Geneva (iGE3), University of Geneva, Geneva, Switzerland., Bergmann S; Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Frayling T; Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, United Kingdom., van Meurs J; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands., Prokisch H; Institute of Neurogenomics, Helmholtz Zentrum München, Neuherberg, Germany.; Institute of Human Genetics, Technical University Munich, Munich, Germany., Ahsan H; Department of Public Health Sciences, University of Chicago, Chicago, IL, USA., Pierce BL; Department of Public Health Sciences, University of Chicago, Chicago, IL, USA., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Boomsma DI; Netherlands Twin Register, Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam Public Health Research Institute and Amsterdam Neuroscience, Amsterdam, the Netherlands., Psaty BM; Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, WA, USA., Gharib SA; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.; Department of Medicine, University of Washington, Seattle, WA, USA., Awadalla P; Computational Biology, Ontario Institute for Cancer Research, Toronto, Ontario, Canada., Milani L; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Ouwehand WH; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.; NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.; Human Genetics, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom., Downes K; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.; NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom., Stegle O; Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom.; Division of Computational Genomics and Systems Genetics, German Cancer Research Center, Heidelberg, Germany., Battle A; Department of Computer Science, Johns Hopkins University, Baltimore, MD, USA.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA., Visscher PM; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., Yang J; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.; School of Life Sciences, Westlake University, Hangzhou, China.; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China., Scholz M; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany., Powell J; Garvan Institute of Medical Research, Garvan-Weizmann Centre for Cellular Genomics, Sydney, New South Wales, Australia.; UNSW Cellular Genomics Futures Institute, University of New South Wales, Sydney, New South Wales, Australia., Gibson G; School of Biological Sciences, Georgia Tech, Atlanta, GA, USA., Esko T; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Franke L; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. lude@ludesign.nl.; Oncode Institute, Amsterdam, the Netherlands. lude@ludesign.nl.

Publikováno v: Nature genetics [Nat Genet] 2021 Sep; Vol. 53 (9), pp. 1300-1310. Date of Electronic Publication: 2021 Sep 02.