Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Sónia S Leal"'
Autor:
Sofia B Carvalho, Hugo M Botelho, Sónia S Leal, Isabel Cardoso, Günter Fritz, Cláudio M Gomes
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e76629 (2013)
S100 proteins are small dimeric calcium-binding proteins which control cell cycle, growth and differentiation via interactions with different target proteins. Intrinsic disorder is a hallmark among many signaling proteins and S100 proteins have been
Externí odkaz:
https://doaj.org/article/e4ef1df11a5f4840ae448d955468eb1f
Autor:
Sónia S. Leal, Cláudio M. Gomes
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 9 (2015)
More than 20 distinct gene loci have so far been implicated in amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disorder characterized by progressive neurodegeneration of motor neurons (MN) and death. Most of this distinct set of ALS-re
Externí odkaz:
https://doaj.org/article/7f1628a75624442ca9484d22f8979e37
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1862:797-804
Transthyretin (TTR) has a neuroprotective role in the central nervous system (CNS) in Alzheimer's disease (AD) and cerebral ischemia. Increased levels of TTR and activated insulin-like growth factor I receptor (IGF-IR) are associated with reduced neu
Autor:
Katrin Kierdorf, Bernd Reif, Vanessa K. Morris, Joana S. Cristóvão, Tobias Madl, Sónia S. Leal, Christoph Göbl, Mobina Alemi, Cláudio M. Gomes, Isabel Cardoso, Günter Fritz, Rodrigo David, Javier Martínez, Hugo M. Botelho
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Science Advances
Sci. Adv. 4:eaaq1702 (2018)
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Science Advances
Sci. Adv. 4:eaaq1702 (2018)
A novel role for S100B, a recognized brain distress marker, as a chaperone-like suppressor of Aβ42 aggregation and toxicity.
Amyloid-β (Aβ) aggregation and neuroinflammation are consistent features in Alzheimer’s disease (AD) and strong can
Amyloid-β (Aβ) aggregation and neuroinflammation are consistent features in Alzheimer’s disease (AD) and strong can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66271798d03e8a55cd1b22b18809e80b
https://hdl.handle.net/10216/127409
https://hdl.handle.net/10216/127409
Autor:
Zélia Gouveia, Ana Catarina Cunha Santos, Ana Rita Carlos, Susana Ramos, Roland Stocker, Frederico Aires-da-Silva, Sónia S. Leal, João Gonçalves, Olga Iranzo, Miguel P. Soares, Xiaojing Yuan, Cláudio M. Gomes, Smilja Todorovic, Iqbal Hamza, Ghassan J. Maghzal
Publikováno v:
FEBS Journal
FEBS Journal, 2017, 284 (19), pp.3278-3301. ⟨10.1111/febs.14192⟩
The FEBS journal
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
FEBS Journal, Wiley, 2017, 284 (19), pp.3278-3301. ⟨10.1111/febs.14192⟩
FEBS Journal, 2017, 284 (19), pp.3278-3301. ⟨10.1111/febs.14192⟩
The FEBS journal
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
FEBS Journal, Wiley, 2017, 284 (19), pp.3278-3301. ⟨10.1111/febs.14192⟩
The deposited article is the accepted manuscript (post-print version) posted online 7 August 2017 and provided by The Febs Journal. This article has been accepted for publication and undergone full peer review but has not been through the copyediting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dec98edeaf032d8a197cc09b5091c007
https://hal.science/hal-01793489
https://hal.science/hal-01793489
Publikováno v:
International Journal of Molecular Sciences
Volume 14
Issue 9
Pages 19128-19145
International Journal of Molecular Sciences, Vol 14, Iss 9, Pp 19128-19145 (2013)
Volume 14
Issue 9
Pages 19128-19145
International Journal of Molecular Sciences, Vol 14, Iss 9, Pp 19128-19145 (2013)
Superoxide dismutase 1 (SOD1) aggregation is one of the pathological markers of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disorder. The underlying molecular grounds of SOD1 pathologic aggregation remains obscure as mutations alon
Publikováno v:
Journal of Biological Chemistry. 288:25219-25228
Imbalance in metal ion homeostasis is a hallmark in neurodegenerative conditions involving protein deposition, and amyotrophic lateral sclerosis (ALS) is no exception. In particular, Ca(2+) dysregulation has been shown to correlate with superoxide di
Autor:
Günter Fritz, Ludmilla A. Morozova-Roche, Kiran Yanamandra, Sónia S. Leal, Hugo M. Botelho, Cláudio M. Gomes, Isabel Cardoso
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
S100A6 is a small EF-hand calcium- and zinc-binding protein involved in the regulation of cell proliferation and cytoskeletal dynamics. It is overexpressed in neurodegenerative disorders and a proposed marker for Amyotrophic Lateral Sclerosis (ALS).
Publikováno v:
Coordination Chemistry Reviews. 256:2253-2270
Protein misfolding and conformational changes are a cornerstone of neurodegenerative diseases involving formation and deposition of toxic protein oligomers. Although mutations favor protein aggregation, physiological factors such as labile metal ions
Publikováno v:
Journal of Biological Chemistry. 285:13839-13849
The integral endoplasmic reticulum (ER)-membrane protein VAP-B interacts with various lipid-transfer/binding proteins containing an FFAT motif through its N-terminal MSP domain. A genetic mutation within its MSP domain, P56S, was identified in famili