Single-Site Mutation Induces Water-Mediated Promiscuity in Lignin Breaking Cytochrome P450GcoA

Autor: Warispreet Singh, Sónia F. G. Santos, Paul James, Gary W. Black, Meilan Huang, Kshatresh Dutta Dubey

Publikováno v: Singh, W, Santos, S F G, James, P, Black, G W, Huang, M & Dubey, K D 2022, ' Single-Site Mutation Induces Water-Mediated Promiscuity in Lignin Breaking Cytochrome P450GcoA ', ACS Omega . https://doi.org/10.1021/acsomega.2c00524

Cytochrome P450 GcoA is an enzyme that catalyses the guaiacol unit of lignin during the lignin breakdown via aryl-O-demethylation reaction. This reaction is intriguing and is of commercial importance for its potential application in the production of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0c4d0db2b665e3c68de0523335cdead
https://doi.org/10.1021/acsomega.2c00524

SLMP53-1 Inhibits Tumor Cell Growth through Regulation of Glucose Metabolism and Angiogenesis in a P53-Dependent Manner

Autor: Helena Ramos, Valentina Barcherini, Joana Almeida, Lucília Saraiva, Alexandra T. P. Carvalho, Juliana Calheiros, Sónia F. G. Santos, Maria M. M. Santos

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 2, p 596 (2020)

The Warburg effect is an emerging hallmark of cancer, which has the tumor suppressor p53 as its major regulator. Herein, we unveiled that p53 activation by (S)-tryptophanol-derived oxazoloisoindolinone (SLMP53-1) mediated the reprograming of glucose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec9b02837293cf7bcebe64d4dcc8ddd3
http://europepmc.org/articles/PMC7013701

Excitatory interneurons dominate sensory processing in the spinal substantia gelatinosa of rat

Autor: Sandra Rebelo, Sónia F. A. Santos, Victor A. Derkach, Boris V. Safronov

Publikováno v: The Journal of Physiology. 581:241-254

Substantia gelatinosa (SG, lamina II) is a spinal cord region where most unmyelinated primary afferents terminate and the central nociceptive processing begins. It is formed by several distinct groups of interneurons whose functional properties and s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7eefc58f1616b5d3ad6fdbdf46bb57e7
https://doi.org/10.1113/jphysiol.2006.126912

Transmission efficacy and plasticity in glutamatergic synapses formed by excitatory interneurons of the substantia gelatinosa in the rat spinal cord

Autor: Boris V. Safronov, Liliana L. Luz, Peter Szucs, Deolinda Lima, Sónia F. A. Santos, Victor A. Derkach

Publikováno v: PLoS ONE, Vol 4, Iss 11, p e8047 (2009)
PLoS ONE

BACKGROUND:Substantia gelatinosa (SG, lamina II) is a spinal cord region where most unmyelinated primary afferents terminate and the central nociceptive processing begins. The glutamatergic excitatory interneurons (EINs) form the majority of the SG n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::071e11a80556d842d56c6328a235a53b

Ionic basis of tonic firing in spinal substantia gelatinosa neurons of rat

Autor: Igor V. Melnick, Peter Szucs, Sónia F. A. Santos, Boris V. Safronov, Karolina Szokol

Publikováno v: Journal of neurophysiology. 91(2)

Ionic conductances underlying excitability in tonically firing neurons (TFNs) from substantia gelatinosa (SG) were studied by the patch-clamp method in rat spinal cord slices. Ca2+-dependent K+ (KCA) conductance sensitive to apamin was found to prolo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0acf36b561d55df28d1239fe31c33a5b
https://pubmed.ncbi.nlm.nih.gov/14523064