Sialyl-Tn glycan epitope as a target for pancreatic cancer therapies

Autor: Rafaela Abrantes, Joanne Lopes, Daniel Lopes, Joana Gomes, Sónia A. Melo, Celso A. Reis

Publikováno v: Frontiers in Oncology, Vol 14 (2024)

Pancreatic cancer (PC) is the sixth leading cause of cancer-related deaths worldwide, primarily due to late-stage diagnosis and limited treatment options. While novel biomarkers and immunotherapies are promising, further research into specific molecu

Externí odkaz: https://doaj.org/article/bcff96ad2bde45a7921079a1af7bcb87

Exosomes and Immune Response in Cancer: Friends or Foes?

Autor: Francisco M. Barros, Fatima Carneiro, Jose C. Machado, Sónia A. Melo

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Exosomes are a type of extracellular vesicle whose study has grown exponentially in recent years. This led to the understanding that these structures, far from being inert waste by-products of cellular functioning, are active players in intercellular

Externí odkaz: https://doaj.org/article/abd179560c254a8287101f15408c35fe

Resistance to EGFR inhibitors in lung cancer occurs through horizontal transfer and is associated with increased caveolins expression

Autor: Susana Junqueira-Neto, Ana R. Oliveira, Joana F. Marques, Patrícia Oliveira, Maria G. Fernandes, Venceslau Hespanhol, Ana Barroso, Jorge Pinheiro, Conceição Souto-Moura, Bruno Cavadas, Luísa Pereira, Bárbara Adem, Miguel Silva, Sónia A. Melo, José L. Costa, José C. Machado

Resistance to treatment is a major clinical problem and a major cause of cancer-related deaths. Understanding the biological basis of resistance acquisition is of utmost importance to improve the clinical management of cancer patients. NGS analysis o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e39f1fd5aa6cdb136b1917d6d2130a81
https://doi.org/10.1101/2022.02.20.481179

Abstract 1099: Resistance to anti-EGFR therapy is transferred horizontally between lung cancer cells through caveolin-associated intercellular trafficking

Autor: Susana Junqueira Neto, Ana Rita Oliveira, Joana Fernandes Marques, Gabriela Fernandes, Venceslau Hespanhol, Conceição Souto Moura, Sónia Almeida Melo, José Luís Costa, José Carlos Machado

Publikováno v: Cancer Research. 82:1099-1099

Despite initial benefit from anti-EGFR therapy, patients with EGFR-mutated lung cancer (LC) inevitably relapse. Knowing that the majority of the relapsing cancer cells do not carry the resistance mutation, we hypothesized that resistance to anti-EGFR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::96ac5a5a2fa6ad967b69d9bf69bf6f99
https://doi.org/10.1158/1538-7445.am2022-1099

The state of art of Organizational Communication: the trends of the 21st century

Autor: Sónia Cristina Melo Silva, Gisela Gonçalves, Teresa Ruão

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
CIÊNCIAVITAE
Observatorio (OBS*) v.14 n.4 2020
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação

A comunicação no contexto das organizações está em constante reconfiguração. As novas formas de informação, de interação, de partilha e de consumo que caracterizam as sociedades atuais trazem novos desafios às organizações e às suas es

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3148f63fb293cc8b2686d2ac6eb1c0a6
https://doi.org/10.15847/obsobs14420201652