Výsledky vyhledávání - "Sílvia Paula-Gomes"

Akademický článek

Role of NLRP3 inflammasome and oxidative stress in hepatic insulin resistance and the ameliorative effect of phytochemical intervention

Autor: Isabela Jesus de Deus, Ana Flávia Martins-Silva, Miliane Martins de Andrade Fagundes, Sílvia Paula-Gomes, Fernanda Guimarães Drummond e Silva, Larissa Leandro da Cruz, Aline Rezende Ribeiro de Abreu, Karina Barbosa de Queiroz

Publikováno v: Frontiers in Pharmacology, Vol 14 (2023)

NLRP3 inflammasome has a key role in chronic low-grade metabolic inflammation, and its excessive activation may contribute to the beginning and progression of several diseases, including hepatic insulin resistance (hIR). Thus, this review aims to hig

Externí odkaz: https://doaj.org/article/1937965c51134de3a7ad27d1382ab95b

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Akademický článek

Urocortin 2 promotes hypertrophy and enhances skeletal muscle function through cAMP and insulin/IGF-1 signaling pathways

Autor: Natalia Lautherbach, Dawit A.P. Gonçalves, Wilian A. Silveira, Sílvia Paula-Gomes, Rafael Rossi Valentim, Neusa M. Zanon, Marcelo G. Pereira, Elen H. Miyabara, Luiz C.C. Navegantes, Isis C. Kettelhut

Publikováno v: Molecular Metabolism, Vol 60, Iss , Pp 101492- (2022)

Objective: Although it is well established that urocortin 2 (Ucn2), a peptide member of the corticotrophin releasing factor (CRF) family, and its specific corticotrophin-releasing factor 2 receptor (CRF2R) are highly expressed in skeletal muscle, the

Externí odkaz: https://doaj.org/article/8fb5755fb87d45968e670b90f0f6b511

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Multifunctional Mitochondrial Epac1 Controls Myocardial Cell Death

Autor: Jérôme Roy, Alexandre Lucas, Marion Laudette, Bijan Ghaleh, Olivier Lairez, Florence Tortosa, Caroline Conte, Yannis Sainte-Marie, Pierre Sicard, Malik Bisserier, Frank Lezoualc'h, Sandrine Pons, Sílvia Paula-Gomes, Loubina Fazal, Jeanne Mialet-Perez, Jérémy Fauconnier

Publikováno v: Circulation Research
Circulation Research, American Heart Association, 2017, 120 (4), pp.645-657. ⟨10.1161/CIRCRESAHA.116.309859⟩
Circulation Research, 2017, 120 (4), pp.645-657. ⟨10.1161/CIRCRESAHA.116.309859⟩

Rationale: Although the second messenger cyclic AMP (cAMP) is physiologically beneficial in the heart, it largely contributes to cardiac disease progression when dysregulated. Current evidence suggests that cAMP is produced within mitochondria. Howev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31a152c647645a1ee9a4d2d23d666dc6
https://hal.inrae.fr/hal-03236846

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