The 20S proteasome activator PA28γ controls the compaction of chromatin

Autor: Véronique Baldin, Cristina Vigano, Didier Fesquet, Catherine Bonne-Andrea, Francisca Mechali, Séverine Boulon, Olivier Coux, David Llères, Charlotte Grimaud

Publikováno v: Journal of Cell Science
Journal of Cell Science, Company of Biologists, 2021, 134 (3), ⟨10.1242/jcs.257717⟩

PA28γ (also known as PSME3), a nuclear activator of the 20S proteasome, is involved in the degradation of several proteins regulating cell growth and proliferation and in the dynamics of various nuclear bodies, but its precise cellular functions rem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de000261a7fbd4a1bba840f73351bc40
https://hal.umontpellier.fr/hal-03428214/document

PIP30/FAM192A is a novel regulator of the nuclear proteasome activator PA28γ

Autor: Didier Fesquet, Prisca Boisguerin, Philippe Fort, Corinne Henriquet, Francisca Mechali, Catherine Bonne-Andrea, Véronique Baldin, Séverine Boulon, Thomas Menneteau, Martine Pugnière, Manuelle Ducoux-Petit, Beata Jonik-Nowak, Bertrand Fabre, Olivier Coux, Angus I. Lamond, Odile Burlet-Schiltz, Sylvain de Rossi, Marie-Pierre Bousquet

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2018, 115 (28), pp.E6477-E6486. ⟨10.1073/pnas.1722299115⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2018, 115 (28), pp.E6477-E6486. ⟨10.1073/pnas.1722299115⟩

Significance The 20S proteasome is a key actor of the control of protein levels and integrity in cells. To perform its multiple functions, it works with a series of regulators, among which is a nuclear complex called PA28γ. In particular, PA28γ par

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b58ae2fd3f316304d7821d2f6e57eff
https://hal.science/hal-02267210/file/E6477.full.pdf

The Nucleolus under Stress

Autor: Saskia Hutten, Séverine Boulon, Angus I. Lamond, Belinda J. Westman, François-Michel Boisvert

Publikováno v: Molecular Cell
Molecular Cell; Vol 40

Cells typically respond quickly to stress, altering their metabolism to compensate. In mammalian cells, stress signaling usually leads to either cell-cycle arrest or apoptosis, depending on the severity of the insult and the ability of the cell to re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08646eafdc45ff77ebb8abb4a9edbe0f
https://doi.org/10.1016/j.molcel.2010.09.024

HSP90 and Its R2TP/Prefoldin-like Cochaperone Are Involved in the Cytoplasmic Assembly of RNA Polymerase II

Autor: Dorothée Molle, Karim Azzag, Céline Verheggen, Séverine Boulon, Angus I. Lamond, Stéphanie Boireau, Edouard Bertrand, Marie Cécile Robert, Bérengère Pradet-Balade, Marya Georgieva, Henry Neel, Yasmeen Ahmad

Publikováno v: Molecular Cell; Vol 39
Molecular Cell
Molecular Cell, Elsevier, 2010, 39 (6), pp.912--24. ⟨10.1016/j.molcel.2010.08.023⟩

RNA polymerases are key multisubunit cellular enzymes. Microscopy studies indicated that RNA polymerase I assembles near its promoter. However, the mechanism by which RNA polymerase II is assembled from its 12 subunits remains unclear. We show here t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fe707599cebb855ab360f7680e280cd

A Dynamic Scaffold of Pre-snoRNP Factors Facilitates Human Box C/D snoRNP Assembly

Autor: Kenneth S McKeegan, Edouard Bertrand, Nicholas J. Watkins, Séverine Boulon, Charles Maurice Debieux

Publikováno v: Molecular and Cellular Biology. 27:6782-6793

The box C/D small nucleolar RNPs (snoRNPs) are essential for the processing and modification of rRNA. The core box C/D proteins are restructured during human U3 box C/D snoRNP biogenesis; however, the molecular basis of this is unclear. Here we show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09a8044bbe1fe55d19ac50a136b48544
https://doi.org/10.1128/mcb.01097-07