Zobrazeno 1 - 10 of 13 pro vyhledávání: '"Séverine, Schneider"'
1
Diastereoselective Synthesis of Nonplanar 3-Amino-1,2,4-oxadiazine Scaffold: Structure Revision of Alchornedine
Autor: Shuang-Qi Tang, Frédéric Bihel, Delphine Garnier, Martine Schmitt, Jacques Bricard, Séverine Schneider, Maeva Leloire, Julie Mohr, Patrick Gizzi
Publikováno v: Journal of Organic Chemistry
Journal of Organic Chemistry, American Chemical Society, In press, ⟨10.1021/acs.joc.0c01764⟩
Journal of Organic Chemistry, In press, ⟨10.1021/acs.joc.0c01764⟩
International audience; Herein, we report the diastereoselective synthesis of a 3-amino-1,2,4-oxadiazine (AOXD) scaffold. The presence of a N–O bond in the ring prevents the planar geometry of the aromatic system and induces a strong decrease in th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b72e269e2f2c2b67b432e748bbfa018
https://doi.org/10.1021/acs.joc.0c01764
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2
Identification of an N -acylated- D Arg-Leu-NH 2 Dipeptide as a Highly Selective Neuropeptide FF1 Receptor Antagonist That Potently Prevents Opioid-Induced Hyperalgesia
Autor: Patrick Gizzi, Brigitte Ilien, Raphaëlle Quillet, Valérie Kugler, Frédéric Simonin, Valérie Simonneaux, Martine Schmitt, Frédéric Bihel, Khadija Elhabazi, Valérie Utard, Jo B. Henningsen, Armand Drieu la Rochelle, Séverine Schneider
Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2021, 64 (11), pp.7555-7564. ⟨10.1021/acs.jmedchem.1c00256⟩
RFamide-related peptide-3 (RFRP-3) and neuropeptide FF (NPFF) target two different receptor subtypes called neuropeptide FF1 (NPFF1R) and neuropeptide FF2 (NPFF2R) that modulate several functions. However, the study of their respective role is severe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc033340f680288639fd0c6e10518c96
https://hal.archives-ouvertes.fr/hal-03363456/document
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3
Identification of an
Autor: Raphaëlle, Quillet, Séverine, Schneider, Valérie, Utard, Armand, Drieu la Rochelle, Khadija, Elhabazi, Jo Beldring, Henningsen, Patrick, Gizzi, Martine, Schmitt, Valérie, Kugler, Valérie, Simonneaux, Brigitte, Ilien, Frédéric, Simonin, Frédéric, Bihel
Publikováno v: Journal of medicinal chemistry. 64(11)
RFamide-related peptide-3 (RFRP-3) and neuropeptide FF (NPFF) target two different receptor subtypes called neuropeptide FF1 (NPFF1R) and neuropeptide FF2 (NPFF2R) that modulate several functions. However, the study of their respective role is severe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1e529d376378670e47de2cac05128375
https://pubmed.ncbi.nlm.nih.gov/34008968
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5
A bifunctional biased mu opioid agonist-neuropeptide FF receptor antagonist as analgesic with improved acute and chronic side effects
Autor: Steven Ballet, Armand Drieu la Rochelle, Pieter Mampuys, Valérie Utard, Frédéric Bihel, Séverine Schneider, Mariana Spetea, François Daubeuf, Karel Guillemyn, Tom Willemse, Maria Dumitrascuta, Nelly Frossard, Bert U. W. Maes, Raphaëlle Quillet, Charlotte Martin, Frédéric Simonin
Publikováno v: Pain
PAIN
PAIN, Elsevier, 2018, 159 (9), pp.1705-1718. ⟨10.1097/j.pain.0000000000001262⟩
Opioid analgesics, such as morphine, oxycodone and fentanyl, are the cornerstones for treating moderate to severe pain. However, upon chronic administration, their efficiency is limited by prominent side effects such as analgesic tolerance and depend
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c453b72695ed1438ea7ad7e1b1b004b1
https://hdl.handle.net/10067/1506770151162165141
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6
RF313, an orally bioavailable neuropeptide FF receptor antagonist, opposes effects of RF-amide-related peptide-3 and opioid-induced hyperalgesia in rodents
Autor: Benoit Petit-Demoulière, Elodie Schneider, Jean-Paul Humbert, Guy Simonnet, Caroline Ancel, Meric Ben Boujema, Valérie Utard, Hamid Meziane, Frédéric Simonin, Massimiliano Beltramo, Jean-Jacques Bourguignon, Frédéric Bihel, Séverine Schneider, Emilie Laboureyras, Khadija Elhabazi, Brigitte Ilien, Isabelle Bertin, Valérie Simonneaux, Raphaëlle Quillet, Martine Schmitt, Bernard Bucher, Tania Sorg
Publikováno v: Neuropsychopharmacology (118), 188-198. (2017)
Neuropsychopharmacology
Neuropsychopharmacology, Nature Publishing Group, 2017, 118, pp.188-198. ⟨10.1016/j.neuropharm.2017.03.012⟩
Neuropharmacology
Neuropharmacology, Elsevier, 2017, 118, pp.188-198. ⟨10.1016/j.neuropharm.2017.03.012⟩
Neuropsychopharmacology, 2017, 118, pp.188-198. ⟨10.1016/j.neuropharm.2017.03.012⟩
Although opiates represent the most effective analgesics, their use in chronic treatments is associated with numerous side effects including the development of pain hypersensitivity and analgesic tolerance. We recently identified a novel orally activ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba32ca33d553c23584c91375ed668b85
http://prodinra.inra.fr/record/388777
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7
Development of Dipeptidic hGPR54 Agonists
Autor: Christelle Doebelin, Frédéric Simonin, Frédéric Bihel, Isabelle Bertin, Séverine Schneider, Caroline Ancel, Martine Schmitt, Valérie Simonneaux, Jean-Jacques Bourguignon
Publikováno v: ChemMedChem
ChemMedChem, Wiley-VCH Verlag, 2016, 11 (19), pp.2147-2154. ⟨10.1002/cmdc.201600331⟩
ChemMedChem, 2016, 11 (19), pp.2147-2154. ⟨10.1002/cmdc.201600331⟩
A series of dipeptides were designed as potential agonists of the human KiSS1-derived peptide receptor (hGPR54). While the sequence Arg-Trp-NH2 was the most efficient in terms of affinity, we established a convergent synthetic strategy to optimize th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19a2a6deb798bb36befc43872bcb796d
https://hal.archives-ouvertes.fr/hal-02368845
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8
ChemInform Abstract: Synthesis of 3-Amino-3,4-dihydro-1H-quinolin-2-ones Through Regioselective Palladium-Catalyzed Intramolecular Cyclization
Autor: Marie Niederst, François Hallé, Olivier Van der Poorten, Steven Ballet, Frédéric Bihel, Christelle Doebelin, Martine Schmitt, Séverine Schneider
Publikováno v: ChemInform. 47
In this Letter we explored the regioselective cyclization of 2-bromophenylalanine derivatives to access enantiopure dihydroquinolinones via an intramolecular regioselective Buchwald–Hartwig cyclization using Pd 2 (dba) 3 /XPhos as a catalytic syste
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fd7ecdcdbaf4ea7d2ca41e5a75711549
https://doi.org/10.1002/chin.201630176
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9
Synthesis of 3-amino-3,4-dihydro-1H-quinolin-2-ones through regioselective palladium-catalyzed intramolecular cyclization
Autor: Frédéric Bihel, Martine Schmitt, Marie Niederst, Séverine Schneider, Christelle Doebelin, François Hallé, Olivier Van der Poorten, Steven Ballet
Publikováno v: Tetrahedron Letters
Tetrahedron Letters, Elsevier, 2016, 57 (14), pp.1547-1550. ⟨10.1016/j.tetlet.2016.02.094⟩
In this Letter we explored the regioselective cyclization of 2-bromophenylalanine derivatives to access enantiopure dihydroquinolinones via an intramolecular regioselective Buchwald–Hartwig cyclization using Pd 2 (dba) 3 /XPhos as a catalytic syste
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e36148fe2f3bb59ceec58d6a4d43d729
https://hal.archives-ouvertes.fr/hal-02290245
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10
Effects of systematic N-terminus deletions and benzoylations of endogenous RF-amide peptides on NPFF1R, NPFF2R, GPR10, GPR54 and GPR103
Autor: Séverine Schneider, Laurent Roumeas, Christelle Doebelin, Jean-Jacques Bourguignon, Martine Schmitt, Jean-Paul Humbert, Frédéric Bihel, Frédéric Simonin, Isabelle Bertin
Publikováno v: Peptides
Peptides, Elsevier, 2015, 71, pp.156-161. ⟨10.1016/j.peptides.2015.07.016⟩
Mammalian RF-amide peptides including RF-amide-related peptides-1 and -3, neuropeptides AF and FF, Prolactin releasing peptides, Kisspeptins and RFa peptides are currently considered endogenous peptides for the GPCRs NPFF1R, NPFF2R, GPR10, GPR54 and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd6efe74facb265c736a263854b2faf4
https://hal.archives-ouvertes.fr/hal-02997151
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