Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Sérgio T Ferreira"'
Autor:
Margaret H Magdesian, Matthias Gralle, Luiz H Guerreiro, Paulo José I Beltrão, Milena M V F Carvalho, Luís Eduardo da S Santos, Fernando G de Mello, Ricardo A M Reis, Sérgio T Ferreira
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22857 (2011)
The amyloid precursor protein (APP) is well known for giving rise to the amyloid-β peptide and for its role in Alzheimer's disease. Much less is known, however, on the physiological roles of APP in the development and plasticity of the central nervo
Externí odkaz:
https://doaj.org/article/f79b5e71009f43b2a9cfc8411a12416d
Autor:
Leonardo M Saraiva, Gisele S Seixas da Silva, Antonio Galina, Wagner S da-Silva, William L Klein, Sérgio T Ferreira, Fernanda G De Felice
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15230 (2010)
Brain accumulation of the amyloid-β peptide (Aβ) and oxidative stress underlie neuronal dysfunction and memory loss in Alzheimer's disease (AD). Hexokinase (HK), a key glycolytic enzyme, plays important pro-survival roles, reducing mitochondrial re
Externí odkaz:
https://doaj.org/article/1fefc9085b5a472a94a10a22fe63bf4b
Publikováno v:
Molecular and Cellular Biochemistry. 159:105-114
The major protein in the sarcoplasmic reticulum (SR) membrane is the Ca2+ transporting ATPase which carries out active Ca2+ pumping at the expense of ATP hydrolysis. The aim of this work was to elucidate the mechanisms by which oxidative stress induc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ef09741279f7a964d2503acbe82d94e
https://doi.org/10.1007/bf00420912
https://doi.org/10.1007/bf00420912
Autor:
Marcelo N N, Vieira, Letícia, Forny-Germano, Leonardo M, Saraiva, Adriano, Sebollela, Ana M Blanco, Martinez, Jean-Christophe, Houzel, Fernanda G, De Felice, Sérgio T, Ferreira
Publikováno v:
Journal of neurochemistry. 103(2)
Protein aggregation and amyloid accumulation in different tissues are associated with cellular dysfunction and toxicity in important human pathologies, including Alzheimer's disease and various forms of systemic amyloidosis. Soluble oligomers formed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::141bc613ae414b614c4653e206e06cdf
https://pubmed.ncbi.nlm.nih.gov/17727639
https://pubmed.ncbi.nlm.nih.gov/17727639
Autor:
Adriano, Sebollela, Thiago C, Cagliari, Gabriel S C S, Limaverde, Alex, Chapeaurouge, Marcos H F, Sorgine, Tatiana, Coelho-Sampaio, Carlos H I, Ramos, Sérgio T, Ferreira
Publikováno v:
The Journal of biological chemistry. 280(36)
The biological activity of granulocyte-macrophage colony-stimulating factor (GM-CSF) is modulated by the sulfated glycosaminoglycans (GAGs) heparan sulfate and heparin. However, the molecular mechanisms involved in such interactions are still not com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8b4f2d6e598d41ef35879e0120f11357
https://pubmed.ncbi.nlm.nih.gov/16027123
https://pubmed.ncbi.nlm.nih.gov/16027123
Publikováno v:
Cellular and molecular neurobiology. 22(5-6)
1. Despite major efforts aimed at elucidating the molecular basis and physiopathology of Alzheimer's disease (AD), there is still no effective treatment available for this devastating disorder. The biological mechanisms underlying the development of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::acb44d94232fd173aa2e0d63e9d34769
https://pubmed.ncbi.nlm.nih.gov/12585679
https://pubmed.ncbi.nlm.nih.gov/12585679
Publikováno v:
European journal of biochemistry. 269(22)
The structures and stabilities of recombinant chicken muscle troponin I (TnI) and T (TnT) were investigated by a combination of bis-ANS binding and equilibrium unfolding studies. Unlike most folded proteins, isolated TnI and TnT bind the hydrophobic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9632cca7e8f1f6a75a80b19af64bbc52
https://pubmed.ncbi.nlm.nih.gov/12423346
https://pubmed.ncbi.nlm.nih.gov/12423346
Autor:
Braga de Freitas, Guilherme1, Araújo Gonçalves, Rafaella1, Gralle, Matthias1 gralle@bioqmed.ufrj.br
Publikováno v:
BMC Evolutionary Biology. 4/12/2016, Vol. 16, p1-11. 11p.
Autor:
Asija, Začiragić
For decades, scientific efforts have been made to understand obesity and related diseases such as type 2 diabetes and neurodegeneration, and their link with meta-inflammation. Adipose tissue is, at present, viewed as an endocrine organ with important
Alzheimer's Disease: New Beginnings focuses on the future promise for therapeutic breakthroughs in light of notable clinical trial failures. The volume editors used a combination of scientometric evaluations to determine the most promising new approa