Zobrazeno 1 - 10 of 19 pro vyhledávání: '"Sérgio P Bydlowski"'
1
Akademický článek
Synthetic nanoemulsion resembling a protein-free model of 7-ketocholesterol containing low density lipoprotein: In vitro and in vivo studies
Autor: Giovani M Favero, Raul C Maranhão, Durvanei A Maria, Débora Levy, Sérgio P Bydlowski
Publikováno v: Biological Research, Vol 43, Iss 4, Pp 439-444 (2010)
7-ketocholesterol (7-KC) differs from cholesterol by a functional ketone group at C7. It is an oxygenated cholesterol derivative (oxysterol), commonly present in oxidized low-density lipoprotein (LDL). Oxysterols are generated and participate in seve
Externí odkaz: https://doaj.org/article/1fe0cc1405854f5e8d2381e7d72de4ff
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2
Akademický článek
Influence of Human Bone Marrow Mesenchymal Stem Cells Secretome from Acute Myeloid Leukemia Patients on the Proliferation and Death of K562 and K562-Lucena Leukemia Cell Lineages
Autor: Fábio Alessandro de Freitas, Débora Levy, Cadiele Oliana Reichert, Juliana Sampaio-Silva, Pedro Nogueira Giglio, Luís Alberto de Pádua Covas Lage, Marco Kawamura Demange, Juliana Pereira, Sérgio Paulo Bydlowski
Publikováno v: International Journal of Molecular Sciences, Vol 25, Iss 9, p 4748 (2024)
Leukemias are among the most prevalent types of cancer worldwide. Bone marrow mesenchymal stem cells (MSCs) participate in the development of a suitable niche for hematopoietic stem cells, and are involved in the development of diseases such as leuke
Externí odkaz: https://doaj.org/article/2051a1dd2fac43fe8ae10554ababacb0
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3
Akademický článek
New genetic prognostic biomarkers in primary central nervous system lymphoma (PCNSL)
Autor: Diego Gomes Candido Reis, Débora Levy, Luís Alberto de Pádua Covas Lage, Hebert Fabrício Culler, Vanderson Rocha, Sérgio Paulo Bydlowski, Maria Cláudia Nogueira Zerbini, Juliana Pereira
Publikováno v: Brain and Behavior, Vol 11, Iss 4, Pp n/a-n/a (2021)
Abstract Background PCNSL is a rare extranodal NHL with poor prognosis. Tumorigenesis has been associated with hyperactivation of BCR downstream and NFkB pathways. We studied the prognosis of the relative expression profile of target genes of NFkB pa
Externí odkaz: https://doaj.org/article/d3bb88e603f643259f29152b3a6a5a8f
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4
Akademický článek
Effects of Oxysterols on Immune Cells and Related Diseases
Autor: Fábio Alessandro de Freitas, Débora Levy, Cadiele Oliana Reichert, Edecio Cunha-Neto, Jorge Kalil, Sérgio Paulo Bydlowski
Publikováno v: Cells, Vol 11, Iss 8, p 1251 (2022)
Oxysterols are the products of cholesterol oxidation. They have a wide range of effects on several cells, organs, and systems in the body. Oxysterols also have an influence on the physiology of the immune system, from immune cell maturation and migra
Externí odkaz: https://doaj.org/article/6e09350bda5c4af88b9fddb6f2f73ef9
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5
Akademický článek
Impact of Oxysterols on Cell Death, Proliferation, and Differentiation Induction: Current Status
Autor: Fábio Alessandro de Freitas, Débora Levy, Amira Zarrouk, Gérard Lizard, Sérgio Paulo Bydlowski
Publikováno v: Cells, Vol 10, Iss 9, p 2301 (2021)
Oxysterols are oxidized derivatives of cholesterol produced by enzymatic activity or non-enzymatic pathways (auto-oxidation). The oxidation processes lead to the synthesis of about 60 different oxysterols. Several oxysterols have physiological, patho
Externí odkaz: https://doaj.org/article/795a1ae6a2594ab680212cca79cdba7b
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6
Akademický článek
Relation of Macrophage Migration Inhibitory Factor to Pulmonary Hemodynamics and Vascular Structure and Carbamyl-Phosphate Synthetase I Genetic Variations in Pediatric Patients with Congenital Cardiac Shunts
Autor: Nair Y. Maeda, Vera D. Aiello, Paulo C. Santos, Ana M. Thomaz, Luiz J. Kajita, Sérgio P. Bydlowski, Antonio Augusto Lopes
Publikováno v: Mediators of Inflammation, Vol 2019 (2019)
Macrophage migration inhibitory factor (MIF) plays an important pathophysiological role in pulmonary hypertension (PHT). Previously, we demonstrated that serum MIF is increased in pediatric PHT associated with congenital heart disease (CHD). In the p
Externí odkaz: https://doaj.org/article/d7e2763f0530467ea9ce9207068f98f6
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7
Azidothymidine is effective against human multiple myeloma: a new use for an old drug?
Autor: Juliana, Pereira, Débora, Levy, Jorge L M, Ruiz, Graciela A, Brocardo, Kleber A, Ferreira, Renata O, Costa, Rodrigo G, Queiroz, Durvanei A, Maria, Abrahao E Hallack, Neto, Dalton A F, Chamone, Sérgio P, Bydlowski
Publikováno v: Anti-cancer agents in medicinal chemistry. 13(1)
Azidothymidine (AZT) is an antiretroviral drug that affects cell proliferation, apoptosis, and the NF-κB pathway. As multiple myeloma (MM) presents with constitutive activation of NF-κB, we analyzed the effect of AZT on human MM cell lines. We eval
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::37b556a1556f7847058e28cfc8826e5c
https://pubmed.ncbi.nlm.nih.gov/22931421
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8
Synthetic nanoemulsion resembling a protein-free model of 7-ketocholesterol containing low density lipoprotein: In vitro and in vivo studies
Autor: Giovani M, Favero, Raul C, Maranhão, Durvanei A, Maria, Débora, Levy, Sérgio P, Bydlowski
Publikováno v: Biological research. 43(4)
7-ketocholesterol (7-KC) differs from cholesterol by a functional ketone group at C7. It is an oxygenated cholesterol derivative (oxysterol), commonly present in oxidized low-density lipoprotein (LDL). Oxysterols are generated and participate in seve
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b3e5ed3c243f4eb24d2c4a53ef41453d
https://pubmed.ncbi.nlm.nih.gov/21526270
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10
Akademický článek
Antioxidant Properties and Cytoprotective Effect of Pistacia lentiscus L. Seed Oil against 7β-Hydroxycholesterol-Induced Toxicity in C2C12 Myoblasts: Reduction in Oxidative Stress, Mitochondrial and Peroxisomal Dysfunctions and Attenuation of Cell Death
Autor: Imen Ghzaiel, Amira Zarrouk, Thomas Nury, Michela Libergoli, Francesca Florio, Souha Hammouda, Franck Ménétrier, Laure Avoscan, Aline Yammine, Mohammad Samadi, Norbert Latruffe, Stefano Biressi, Débora Levy, Sérgio Paulo Bydlowski, Sonia Hammami, Anne Vejux, Mohamed Hammami, Gérard Lizard
Publikováno v: Antioxidants, Vol 10, Iss 11, p 1772 (2021)
Aging is characterized by a progressive increase in oxidative stress, which favors lipid peroxidation and the formation of cholesterol oxide derivatives, including 7β-hydroxycholesterol (7β-OHC). This oxysterol, which is known to trigger oxidative
Externí odkaz: https://doaj.org/article/41dea98b38f14b49844d725e78e7ee59
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