Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Sérgio F. de Almeida"'
Autor:
Bruno A. Cardoso, Mafalda Duque, Ana Gírio, Rita Fragoso, Mariana L. Oliveira, James R. Allen, Leila R. Martins, Nádia C. Correia, André Bortolini Silveira, Alexandra Veloso, Shunsuke Kimura, Lisa Demoen, Filip Matthijssens, Sima Jeha, Cheng Cheng, Ching-Hon Pui, Ana R. Grosso, João L. Neto, Sérgio F. de Almeida, Pieter Van Vlieberghe, Charles G. Mullighan, J. Andres Yunes, David M. Langenau, Françoise Pflumio, João T. Barata
Publikováno v:
Haematologica, Vol 109, Iss 6 (2023)
CASZ1 is a conserved transcription factor involved in neural development, blood vessel assembly and heart morphogenesis. CASZ1 has been implicated in cancer, either suppressing or promoting tumor development depending on the tissue. However, the impa
Externí odkaz:
https://doaj.org/article/e0e1c7294ff1479dbb2741b0c1056932
Autor:
Inês Faleiro, Ana I. Afonso, André Balsinha, Beatriz Lucas, Robert M. Martin, Edgar R. Gomes, Sérgio F. de Almeida
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
DNA double-strand breaks (DSBs) trigger specialized cellular mechanisms that collectively form the DNA damage response (DDR). In proliferating cells, the DDR serves the function of mending DNA breaks and satisfying the cell-cycle checkpoints. Distinc
Externí odkaz:
https://doaj.org/article/dd4ab52e97204266a76ea34d3861c1f5
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
To ward off against the catastrophic consequences of persistent DNA double-strand breaks (DSBs), eukaryotic cells have developed a set of complex signaling networks that detect these DNA lesions, orchestrate cell cycle checkpoints and ultimately lead
Externí odkaz:
https://doaj.org/article/f80b5fb8431a48af955ae03d4fdc956d
Autor:
Sérgio F. de Almeida, Edgar R. Gomes
Publikováno v:
Developmental cell. 56(22)
Summary Loss of nuclear integrity correlates with increased DNA damage in different tissues. In a recent issue of Cell, Nader et al. reveal that nuclear envelope ruptures in dense tissue microenvironments cause TREX1-dependent DNA damage and promote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d444561fe76954f8fc45823a732f04b3
https://pubmed.ncbi.nlm.nih.gov/34551315
https://pubmed.ncbi.nlm.nih.gov/34551315
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Copyright © 2021 JoVE Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License
DNA double-strand breaks (DSB) are the most severe type of DNA damage. Despite the catastrophic consequences on genome integrity, it remains so far e
DNA double-strand breaks (DSB) are the most severe type of DNA damage. Despite the catastrophic consequences on genome integrity, it remains so far e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c722561378ad5e15021d048c7c0929d0
https://doi.org/10.3791/62968-v
https://doi.org/10.3791/62968-v
Autor:
Ana R Grosso, Ana P Leite, Sílvia Carvalho, Mafalda R Matos, Filipa B Martins, Alexandra C Vítor, Joana MP Desterro, Maria Carmo-Fonseca, Sérgio F de Almeida
Publikováno v:
eLife, Vol 4 (2015)
Aberrant expression of cancer genes and non-canonical RNA species is a hallmark of cancer. However, the mechanisms driving such atypical gene expression programs are incompletely understood. Here, our transcriptional profiling of a cohort of 50 prima
Externí odkaz:
https://doaj.org/article/e3efa85c36414b138546a9943c6ffe5a
Autor:
Sílvia Carvalho, Alexandra C Vítor, Sreerama C Sridhara, Filipa B Martins, Ana C Raposo, Joana MP Desterro, João Ferreira, Sérgio F de Almeida
Publikováno v:
eLife, Vol 3 (2014)
Histone modifications establish the chromatin states that coordinate the DNA damage response. In this study, we show that SETD2, the enzyme that trimethylates histone H3 lysine 36 (H3K36me3), is required for ATM activation upon DNA double-strand brea
Externí odkaz:
https://doaj.org/article/b0756fdf598e454cae01f2b4fb62fd0d
Autor:
Ofer Regev, Ronen Alon, Yossi Ovadya, Francesco Roncato, Gabi Gerlitz, Sandeep Kumar Yadav, Yoseph Addadi, Ester Feldmesser, Sérgio F. de Almeida, Marina Kizner, Nehora Levi, João C. Sabino, Diana Drago-Garcia, Sara W. Feigelson, Lukasz Kaczmarczyk, Samuel Ovadia
Publikováno v:
Cancers
Volume 13
Issue 10
Cancers, Vol 13, Iss 2383, p 2383 (2021)
Volume 13
Issue 10
Cancers, Vol 13, Iss 2383, p 2383 (2021)
Simple Summary The nucleus is the largest and stiffest organelle of tumor cells. Cancer metastasis depends on the ability of cancer cells circulating in the blood to exit blood vessels and survive in target organs. The roles of the shell (lamina) of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acb4cde374b3cc606ddb62fe3710b3fa
https://lirias.kuleuven.be/handle/123456789/683271
https://lirias.kuleuven.be/handle/123456789/683271
Autor:
Jacques Neefjes, Josef Anrather, Vladimir Benes, Luis F. Moita, Michael Sattler, Sebastian Weis, André Barros, Raffaella Gozzelino, Ângelo Chora, Henrique G. Colaço, Miguel P. Soares, Arie Geerlof, Pedro Pereira, Eleni Kyriakou, Isa Santos, Nadja Pejanovic, Katharina L. Willmann, Catarina Moita, Tiago R. Velho, Sérgio F. de Almeida, Dora Pedroso, João A. Ferreira, Filipa Batalha Martins, Sílvia Carvalho, Ana C. Messias, Ana Neves-Costa
Publikováno v:
SSRN Electronic Journal.
Anthracyclines are among the most used and effective anticancer drugs. Their activity has been attributed to DNA double-strand breaks resulting from topoisomerase II poisoning and to eviction of histones from select sites in the genome. Here we show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cc6b5093b6569991ee037f0c307011f
https://doi.org/10.2139/ssrn.3875775
https://doi.org/10.2139/ssrn.3875775
Publikováno v:
Frontiers in Molecular Biosciences
Frontiers in Molecular Biosciences, Frontiers Media, 2020, 7, ⟨10.3389/fmolb.2020.00024⟩
Frontiers in Molecular Biosciences, Vol 7 (2020)
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Digital.CSIC. Repositorio Institucional del CSIC
instname
idUS. Depósito de Investigación de la Universidad de Sevilla
Frontiers in Molecular Biosciences, Frontiers Media, 2020, 7, ⟨10.3389/fmolb.2020.00024⟩
Frontiers in Molecular Biosciences, Vol 7 (2020)
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Digital.CSIC. Repositorio Institucional del CSIC
instname
idUS. Depósito de Investigación de la Universidad de Sevilla
To ward off against the catastrophic consequences of persistent DNA double-strand breaks (DSBs), eukaryotic cells have developed a set of complex signaling networks that detect these DNA lesions, orchestrate cell cycle checkpoints and ultimately lead
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07e0e0736246065f19724974f8131932
https://hal.archives-ouvertes.fr/hal-03011382
https://hal.archives-ouvertes.fr/hal-03011382