N6-Adenosine Methylation of miRNA-200b-3p Influences Its Functionality and Is a Theranostic Tool

Autor: Briand, Joséphine, Sérandour, Aurélien A., Nadaradjane, Arulraj, Bougras-Cartron, Gwenola, Heymann, Dominique, Ory, Benjamin, Vallette, François M., Cartron, Pierre-François

Publikováno v: In Molecular Therapy - Nucleic Acids 4 December 2020 22:72-83

Reduction of RUNX1 transcription factor activity by a CBFA2T3-mimicking peptide: application to B cell precursor acute lymphoblastic leukemia

Autor: Jakobczyk, Hélène, Debaize, Lydie, Soubise, Benoit, Avner, Stéphane, Rouger-Gaudichon, Jérémie, Commet, Séverine, Jiang, Yan, Sérandour, Aurélien A., Rio, Anne-Gaëlle, Carroll, Jason S., Wichmann, Christian, Lie-a-Ling, Michael, Lacaud, Georges, Corcos, Laurent, Salbert, Gilles, Galibert, Marie-Dominique, Gandemer, Virginie, Troadec, Marie-Bérengère

Publikováno v: Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-17 (2021)
Journal of Hematology & Oncology
Journal of Hematology and Oncology
Journal of Hematology and Oncology, 2021, 14 (1), pp.47. ⟨10.1186/s13045-021-01051-z⟩
Journal of Hematology and Oncology, BioMed Central, 2021, 14, pp.47. ⟨10.1186/s13045-021-01051-z⟩
BASE-Bielefeld Academic Search Engine

Background: B Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) is the most common pediatric cancer. Identifying key players involved in proliferation of BCP-ALL cells is crucial to propose new therapeutic targets. Runt Related Transcription Fact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::be3f951daa53703c7202268b8f26f6aa
https://doaj.org/article/3e5be24cee0f4d4db6d0258b58f9a08b

ETV6-RUNX1 and RUNX1 directly regulate RAG1 expression: one more step in the understanding of childhood B-cell acute lymphoblastic leukemia leukemogenesis

Autor: Jakobczyk, Hélène, Jiang, Yan, Debaize, Lydie, Soubise, Benoit, Avner, Stéphane, Sérandour, Aurélien A, Rouger-Gaudichon, Jérémie, Rio, Anne-Gaëlle, Carroll, Jason S, Raslova, Hana, Gilot, David, Liu, Ziling, Demengeot, Jocelyne, Salbert, Gilles, Douet-Guilbert, Nathalie, Corcos, Laurent, Galibert, Marie-Dominique, Gandemer, Virginie, Troadec, Marie-Bérengère

ETV6-RUNX1 and RUNX1 directly promote RAG1 expression. ETV6-RUNX1 and RUNX1 preferentially bind to the −1200 bp enhancer of RAG1 and the −80 bp promoter of RAG1 gene respectively, and compete for these bindings. ETV6-RUNX1 and RUNX1 induce an exc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______109::90466abfb6ae2235f6f3f7cfffc8fe4c
https://www.repository.cam.ac.uk/handle/1810/333508

Additional file 2 of Reduction of RUNX1 transcription factor activity by a CBFA2T3-mimicking peptide: application to B cell precursor acute lymphoblastic leukemia

Autor: Jakobczyk, Hélène, Debaize, Lydie, Benoit Soubise, Avner, Stéphane, Rouger-Gaudichon, Jérémie, Commet, Séverine, Jiang, Yan, Sérandour, Aurélien A., Anne-Gaëlle Rio, Carroll, Jason S., Wichmann, Christian, Lie-A-Ling, Michael, Lacaud, Georges, Corcos, Laurent, Salbert, Gilles, Galibert, Marie-Dominique, Gandemer, Virginie, Troadec, Marie-Bérengère

Additional file 2: Figures S1, S2 and S3 and their legends.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b70de5c3a23ae6c7e52fd4e3a1aee53

DNA hydroxymethylation is associated with disease severity and persists at enhancers of oncogenic regions in multiple myeloma

Autor: Alberge, Jean-Baptiste, Magrangeas, Florence, Wagner, Mirko, Denié, Soline, Guérin-Charbonnel, Catherine, Campion, Loïc, Attal, Michel, Avet-Loiseau, Hervé, Carell, Thomas, Moreau, Philippe, Minvielle, Stephane, Sérandour, Aurélien

Publikováno v: Clinical Epigenetics
Clinical Epigenetics, BioMed Central, 2020, 12, pp.163. ⟨10.1186/s13148-020-00953-y⟩
Clinical Epigenetics, 2020, 12, pp.163. ⟨10.1186/s13148-020-00953-y⟩

International audience; Background: Multiple myeloma (MM) is a heterogeneous plasma cell malignancy that remains challenging to cure. Global hypomethylation correlates with an aggressive phenotype of the disease, while hypermethylation is observed at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::20fe281484b0c878ddd25302b3f85d26
https://www.hal.inserm.fr/inserm-03006751/file/Alberge2020_Article_DNAHydroxymethylationIsAssocia.pdf