Retinal cholesterol metabolism is perturbated in response to experimental glaucoma in the rat

Autor: Elise Léger-Charnay, Ségolène Gambert, Lucy Martine, Elisabeth Dubus, Marie-Annick Maire, Bénédicte Buteau, Tristan Morala, Vincent Gigot, Alain M. Bron, Lionel Bretillon, Elodie A. Y. Masson

Publikováno v: PLoS ONE, Vol 17, Iss 3 (2022)

Alterations of cholesterol metabolism have been described for many neurodegenerative pathologies, such as Alzheimer’s disease in the brain and age-related macular degeneration in the retina. Recent evidence suggests that glaucoma, which is characte

Externí odkaz: https://doaj.org/article/32bdb84376764ca7a2b10a5f13bcfd6a

Soluble fiber inulin consumption limits alterations of the gut microbiota and hepatic fatty acid metabolism caused by high-fat diet

Autor: Mayssa Albouery, Benoit Chassaing, Marie-Agnès Bringer, Alexis Bretin, Stéphane Grégoire, Niyazi Acar, Ségolène Gambert, Alain M. Bron, Lucy Martine, Bénédicte Buteau

Publikováno v: Nutrients
Nutrients, 2021, 13 (3), pp.1037. ⟨10.3390/nu13031037⟩
Volume 13
Issue 3
Nutrients, MDPI, 2021, 13 (3), pp.1037. ⟨10.3390/nu13031037⟩
Nutrients, Vol 13, Iss 1037, p 1037 (2021)

International audience; Diet shapes the gut microbiota which impacts hepatic lipid metabolism. Modifications in liver fat content are associated with metabolic disorders. We investigated the extent of dietary fat and fiber-induced alterations in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff0b26be4d7c5e3aa451f38df61844d3
https://hal.inrae.fr/hal-03198217/document

Early impairments in the retina of rats fed with high fructose/high fat diet are associated with glucose metabolism deregulation but not dyslipidaemia

Autor: Valérie Febvret, Marie-Annick Maire, Stéphane Grégoire, Niyazi Acar, Ségolène Gambert, Elisa Vidal, Elise Lalarme, Lionel Bretillon

Publikováno v: Scientific Reports 1 (9), . (2019)
Scientific Reports
Scientific Reports, Nature Publishing Group, 2019, 9 (1), ⟨10.1038/s41598-019-42528-9⟩
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)

Way of life changes such as high consumption of processed foods rich in fat and sugar and sedentary lifestyle are associated with the increasing prevalence of metabolic syndrome (MetS) that affects about 35% in the American population. MetS is the ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fc734768965503e1a820f5f7485cfc6
http://prodinra.inra.fr/record/471771

Cholestérol et pathologies oculaires : focus sur le rôle de la cholestérol 24S-hydroxylase (CYP46A1) dans l’homéostasie du cholestérol

Autor: Cynthia Fourgeux, Alain M. Bron, Lucy Martine, Lionel Bretillon, Ségolène Gambert-Nicot, Catherine Creuzot-Garcher

Publikováno v: Cahiers de Nutrition et de Diététique. 50:323-330

Resume La retine est le tissu neurosensoriel de l’œil qui assure la transduction visuelle, c’est-a-dire le codage de l’information lumineuse en influx nerveux. Le terme « retine » regroupe l’association de la retine neurale et de l’epith

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::24b81104614f54fbd040e1929cc8ab06
https://doi.org/10.1016/j.cnd.2015.04.003

Cholesterol metabolism and glaucoma: Modulation of Muller cell membrane organization by 24S-hydroxycholesterol

Autor: Ségolène Gambert, Elodie Masson, Arthur Vannier, Géraldine Lucchi, Arthur Ferrerro, Delphine Pecqueur, Clément Gendrault, Laurent Leclere, Méline Lachot, Lucy Martine, Stéphane Grégoire, Caroline Truntzer, Alain M. Bron, Elise Léger-Charnay, Pierre-Henry Gabrielle, Catherine Creuzot-Garcher, Lionel Bretillon

Publikováno v: Chemistry and Physics of Lipids
Chemistry and Physics of Lipids, Elsevier, 2017, S0009-3084(17)30020-8, ⟨10.1016/j.chemphyslip.2017.05.007⟩
Chemistry and Physics of Lipids, Elsevier, 2017, S0009-3084(17)30020-8, 〈10.1016/j.chemphyslip.2017.05.007〉
Chemistry and Physics of Lipids, Elsevier, 2017, S0009-3084(17)30020-8 (Part B), pp.179-191. ⟨10.1016/j.chemphyslip.2017.05.007⟩

International audience; Glaucoma is a progressive and irreversible blinding neuropathy that is characterized by the loss of retinal ganglion cells (RGCs). Muller Glial Cell (MGC) activation is induced in retinal gliosis. MGCs are the most numerous gl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73eda4e6e7b817618fd12aba41430ee0
https://pubmed.ncbi.nlm.nih.gov/28576383