Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Ségolène Galandrin"'
Autor:
Lauriane Onfroy, Ségolène Galandrin, Stéphanie M. Pontier, Marie-Hélène Seguelas, Du N’Guyen, Jean-Michel Sénard, Céline Galés
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Biased agonism at G protein coupled receptors emerges as an opportunity for development of drugs with enhanced benefit/risk balance making biased ligand identification a priority. However, ligand biased signature, classically inferred from l
Externí odkaz:
https://doaj.org/article/46b62063d1b048b08dc910da43acf68d
Publikováno v:
The International Journal of Biochemistry & Cell Biology. 77:251-263
During the last 10 years, the concept of "biased agonism" also called "functional selectivity" swamped the pharmacology of 7 transmembrane receptors and paved the way for developing signaling pathway-selective drugs with increased efficacy and less a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a3a7fa057cdf0d314a6e5e5a222318d
https://doi.org/10.1016/j.biocel.2016.04.009
https://doi.org/10.1016/j.biocel.2016.04.009
Autor:
Lionel Mourey, Valérie Guillet, Simon Ladevèze, Hedia Marrakchi, Mamadou Daffé, Nathalie Eynard, Vincent Mariaule, Ségolène Galandrin, Cécile Bon, Laurent Maveyraud
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2016, 291 (15), pp.7973-7989. ⟨10.1074/jbc.M115.712612⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2016, 291 (15), pp.7973-7989. ⟨10.1074/jbc.M115.712612⟩
International audience; Mycolic acids are essential components of the mycobacterial cell envelope, and their biosynthetic pathway is one of the targets of first-line antituberculous drugs. This pathway contains a number of potential targets, includin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5067c5019519cabe9ebc568738755152
https://doi.org/10.1074/jbc.m115.712612
https://doi.org/10.1074/jbc.m115.712612
Autor:
N Radha, Ségolène Galandrin, Hedia Marrakchi, Mathieu Léger, Lionel Mourey, Tanjore Balganesh, Rajendra S. Rane, Nathalie Eynard, Kaveri Das, Mamadou Daffé, Valérie Guillet
Publikováno v:
Journal of Biomolecular Screening
Journal of Biomolecular Screening, SAGE Publications, 2013, 18 (5), pp.576-587. ⟨10.1177/1087057112474691⟩
Journal of Biomolecular Screening, SAGE Publications, 2013, 18 (5), pp.576-587. ⟨10.1177/1087057112474691⟩
FadD32, a fatty acyl-AMP ligase (FAAL32) involved in the biosynthesis of mycolic acids, major and specific lipid components of the mycobacterial cell envelope, is essential for the survival of Mycobacterium tuberculosis, the causative agent of tuberc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0030cdc2c26be4fc556f61280a59402
https://doi.org/10.1177/1087057112474691
https://doi.org/10.1177/1087057112474691
Autor:
Jean-Michel Senard, Marie-Hélène Seguelas, Du N’Guyen, Caroline Dubroca, Jean-Louis Banères, Céline M'Kadmi, Yvan Nicaise, Céline Galés, Atul Pathak, Cédric Boularan, Colette Denis, Claire Pilette, Ségolène Galandrin, Jacky Marie
Publikováno v:
Hypertension (Dallas, Tex. : 1979). 68(6)
Hyperactivity of the renin–angiotensin–aldosterone system through the angiotensin II (Ang II)/Ang II type 1 receptor (AT1-R) axis constitutes a hallmark of hypertension. Recent findings indicate that only a subset of AT1-R signaling pathways is c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3227480ac53c369ecb2366ab534398e2
https://pubmed.ncbi.nlm.nih.gov/27698064
https://pubmed.ncbi.nlm.nih.gov/27698064
Autor:
Pedro M. Alzari, Alexandre Stella, Odile Burlet-Schiltz, Virginie Molle, Marco Bellinzoni, Gwenaëlle André-Leroux, Nguyen-Hung Le, Ségolène Galandrin, Hedia Marrakchi, Nathalie Eynard, Mamadou Daffé, Valérie Guillet, Fabienne Bardou, Lionel Mourey, Mathieu Miras
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2016, 291 (43), pp.22793-22805. ⟨10.1074/jbc.M116.748053⟩
Journal of Biological Chemistry 43 (291), 22793-22805. (2016)
Journal of Biological Chemistry, 2016, 291 (43), pp.22793-22805. ⟨10.1074/jbc.M116.748053⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2016, 291 (43), pp.22793-22805. ⟨10.1074/jbc.M116.748053⟩
Journal of Biological Chemistry 43 (291), 22793-22805. (2016)
Journal of Biological Chemistry, 2016, 291 (43), pp.22793-22805. ⟨10.1074/jbc.M116.748053⟩
International audience; Mycolic acids are essential components of the mycobacterial cell envelope, and their biosynthetic pathway is a well known source of antituberculous drug targets. Among the promising new targets in the pathway, FadD32 is an ess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9332e52f2fd2478b89699b6caa3589e9
https://hal.archives-ouvertes.fr/hal-01604694/document
https://hal.archives-ouvertes.fr/hal-01604694/document
Autor:
Klaus Mohr, Michael Hölzel, John Sondek, Evelyn Gaffal, Thomas H. Charpentier, Graeme Milligan, Céline Galés, Tanja Slodczyk, Harald Dargatz, Tobias Bald, Junken Aoki, Yuji Shinjo, Daniel Tietze, Maike Effern, Anna Lena Schmitz, Asuka Inoue, Sylvain Armando, Henrik G. Dohlman, Anne Stößel, Ramona Schrage, Ségolène Galandrin, Gabriele M. König, Michael Hesse, Katrin M. Büllesbach, Christa E. Müller, Manuel Grundmann, Christel Drewke, Stefan Kehraus, Andrew B. Tobin, Diana Imhof, T. Kendall Harden, Suvi Annala, Stéphane A. Laporte, Jesus Gomeza, Thomas Tüting, Velten Horn, Naveen Shridhar, Nicole Merten, Yoon Namkung, Adrian J. Butcher, Daniela Wenzel, Laura Jenkins, Evi Kostenis, Michel Bouvier, Bernd K. Fleischmann, Matthew K. Martz
Publikováno v:
Nature Communications
Despite the discovery of heterotrimeric αβγ G proteins ∼25 years ago, their selective perturbation by cell-permeable inhibitors remains a fundamental challenge. Here we report that the plant-derived depsipeptide FR900359 (FR) is ideally suited t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b26f05dca16b186dc13b71425c09af5
https://eprints.gla.ac.uk/115886/1/115886.pdf
https://eprints.gla.ac.uk/115886/1/115886.pdf
Autor:
Andreas Breit, Stéphanie M. Pontier, Céline Galés, Michel Bouvier, Ségolène Galandrin, Yann Percherancier
Publikováno v:
Journal of Biological Chemistry. 283:24659-24672
Determining the role of lipid raft nanodomains in G protein-coupled receptor signaling remains fraught by the lack of assays directly monitoring rafts in native membranes. We thus combined extensive biochemical and pharmacological approaches to a nan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6bfe9708336146397b5428ffa0353426
https://doi.org/10.1074/jbc.m800778200
https://doi.org/10.1074/jbc.m800778200
Autor:
Serge Mazères, Atul Pathak, Fabien Despas, Morgane Bellot, Cédric Boularan, Heinrich J.G. Matthies, Colette Denis, Jean-Michel Senard, Marie-Hélène Seguelas, Céline Galés, Ségolène Galandrin, Samra Joke Sanni, Jonathan A. Javitch, Véronique Pons, Jakob Lerche Hansen, Aurelio Galli
Hypersecretion of norepinephrine (NE) and angiotensin II (AngII) is a hallmark of major prevalent cardiovascular diseases that contribute to cardiac pathophysiology and morbidity. Herein, we explore whether heterodimerization of presynaptic AngII AT1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7abb449ba66f9e654cf8c6fa886093a
https://europepmc.org/articles/PMC4465922/
https://europepmc.org/articles/PMC4465922/
Autor:
Jean-Philippe Leyris, Eric Trinquet, David Perahia, Mauricio G. S. Costa, Jean Martinez, Didier Gagne, Séverine Denoyelle, Jean-Louis Banères, Gérald Gaibelet, Jacky Marie, Céline Galés, Céline M'Kadmi, Nicolas Floquet, Sophie Mary, Laurent Gavara, Ségolène Galandrin, Jean-Alain Fehrentz, Mathieu Maingot, Marjorie Damian, Bernard Mouillac
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2015, 112 (5), pp.1601-1606. ⟨10.1073/pnas.1414618112⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2015, 112 (5), pp.1601-1606. ⟨10.1073/pnas.1414618112⟩
International audience; How G protein-coupled receptor conformational dynamics control G protein coupling to trigger signaling is a key but still open question. We addressed this question with a model system composed of the purified ghrelin receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e17c2454c955782222221fb41a30bd91
https://pubmed.ncbi.nlm.nih.gov/25605885
https://pubmed.ncbi.nlm.nih.gov/25605885