Výsledky vyhledávání - "Sébastien Wieckowski"

Akademický článek

Toward a Better Understanding of Bioassays for the Development of Biopharmaceuticals by Exploring the Structure-Antibody-Dependent Cellular Cytotoxicity Relationship in Human Primary Cells

Autor: Sébastien Wieckowski, Cécile Avenal, Arturo V. Orjalo, Daniel Gygax, Florian Cymer

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Pharmaceutical manufacturing relies on rigorous methods of quality control of drugs and in particular of the physico-chemical and functional characterizations of monoclonal antibodies. To that end, robust bioassays are very often limited to reporter

Externí odkaz: https://doaj.org/article/7623c79e9e1547e8bbc48c41fffd818d

Zobrazit plný text záznamu

Akademický článek

A phase 1 trial extension to assess immunologic efficacy and safety of prime-boost vaccination with VXM01, an oral T cell vaccine against VEGFR2, in patients with advanced pancreatic cancer

Autor: Friedrich H. Schmitz-Winnenthal, Nicolas Hohmann, Thomas Schmidt, Lilli Podola, Tobias Friedrich, Heinz Lubenau, Marco Springer, Sébastien Wieckowski, Klaus M. Breiner, Gerd Mikus, Markus W. Büchler, Anne-Valerie Keller, Ruhan Koc, Christoph Springfeld, Phillip Knebel, Mariana Bucur, Lars Grenacher, Walter E. Haefeli, Philipp Beckhove

Publikováno v: OncoImmunology, Vol 7, Iss 4 (2018)

VXM01 is a first-in-kind orally applied tumor vaccine based on live attenuated Salmonella typhi carrying an expression plasmid encoding VEGFR2, an antigen expressed on tumor vasculature and a stable and accessible target for anti-angiogenic intervent

Externí odkaz: https://doaj.org/article/f1654b6e955543cab1a035533acfbe75

Zobrazit plný text záznamu

Akademický článek

TCRep 3D: an automated in silico approach to study the structural properties of TCR repertoires.

Autor: Antoine Leimgruber, Mathias Ferber, Melita Irving, Hamid Hussain-Kahn, Sébastien Wieckowski, Laurent Derré, Nathalie Rufer, Vincent Zoete, Olivier Michielin

Publikováno v: PLoS ONE, Vol 6, Iss 10, p e26301 (2011)

TCRep 3D is an automated systematic approach for TCR-peptide-MHC class I structure prediction, based on homology and ab initio modeling. It has been considerably generalized from former studies to be applicable to large repertoires of TCR. First, the

Externí odkaz: https://doaj.org/article/faa0b69c526f44d98ab040d69269f945

Zobrazit plný text záznamu

Data from Tumor Antigen–Specific FOXP3+ CD4 T Cells Identified in Human Metastatic Melanoma: Peptide Vaccination Results in Selective Expansion of Th1-like Counterparts

Autor: Pedro Romero, Daniel E. Speiser, Immanuel F. Luescher, Jean-Marie Tiercy, William W. Kwok, Nathalie Rufer, Sébastien Wieckowski, Lukas Baitsch, Laurent Derré, Danijel Dojcinovic, Gilles Bioley, Camilla Jandus

We have previously shown that vaccination of HLA-A2 metastatic melanoma patients with the analogue Melan-A26-35(A27L) peptide emulsified in a mineral oil induces ex vivo detectable specific CD8 T cells. These are further enhanced when a TLR9 agonist

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5eab1d6aa13b5590d2ee7e4235f69ef4
https://doi.org/10.1158/0008-5472.c.6500465

Zobrazit plný text záznamu

Supplementary Figure 3 from Tumor Antigen–Specific FOXP3+ CD4 T Cells Identified in Human Metastatic Melanoma: Peptide Vaccination Results in Selective Expansion of Th1-like Counterparts

Supplementary Figure 3 from Tumor Antigen–Specific FOXP3+ CD4 T Cells Identified in Human Metastatic Melanoma: Peptide Vaccination Results in Selective Expansion of Th1-like Counterparts

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86f0615d49f4b8b52c11dbc910737f84
https://doi.org/10.1158/0008-5472.22383230.v1

Zobrazit plný text záznamu

Supplementary Figure 2 from Tumor Antigen–Specific FOXP3+ CD4 T Cells Identified in Human Metastatic Melanoma: Peptide Vaccination Results in Selective Expansion of Th1-like Counterparts

Supplementary Figure 2 from Tumor Antigen–Specific FOXP3+ CD4 T Cells Identified in Human Metastatic Melanoma: Peptide Vaccination Results in Selective Expansion of Th1-like Counterparts

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d472beba34cee39b5ae23d6bc70b625
https://doi.org/10.1158/0008-5472.22383233.v1

Zobrazit plný text záznamu

Toward a Better Understanding of Bioassays for the Development of Biopharmaceuticals by Exploring the Structure-Antibody-Dependent Cellular Cytotoxicity Relationship in Human Primary Cells

Autor: Arturo V. Orjalo, Sébastien Wieckowski, Cecile Avenal, Florian Cymer, Daniel Gygax

Publikováno v: Frontiers in Immunology
Frontiers in Immunology, Vol 11 (2020)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd4f45896eb2d1b5123e6c9b51d48358
https://doi.org/10.3389/fimmu.2020.552596

Zobrazit plný text záznamu

GEF-H1 Signaling upon Microtubule Destabilization Is Required for Dendritic Cell Activation and Specific Anti-tumor Responses

Publikováno v: Cell reports
Cell Reports, Vol 28, Iss 13, Pp 3367-3380.e8 (2019)

SUMMARY Dendritic cell (DC) activation is a critical step for anti-tumor T cell responses. Certain chemotherapeutics can influence DC function. Here we demonstrate that chemotherapy capable of microtubule destabilization has direct effects on DC func

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3447cc1ec072a47409f28260058d19bf
https://pubmed.ncbi.nlm.nih.gov/31553907

Zobrazit plný text záznamu

A phase 1 trial extension to assess immunologic efficacy and safety of prime-boost vaccination with VXM01, an oral T cell vaccine against VEGFR2, in patients with advanced pancreatic cancer

Autor: Christoph Springfeld, Heinz Lubenau, Lars Grenacher, Lilli Podola, Ruhan Koc, Nicolas Hohmann, Klaus M. Breiner, Markus W. Büchler, Friedrich H. Schmitz-Winnenthal, Gerd Mikus, Phillip Knebel, Mariana Bucur, Marco Springer, Philipp Beckhove, Anne-Valerie Keller, Walter E. Haefeli, Thomas Schmidt, Sébastien Wieckowski, Tobias Friedrich

Publikováno v: OncoImmunology, Vol 7, Iss 4 (2018)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1051589d3ca18d59a3c4cfe884829ff5
https://doi.org/10.1080/2162402x.2017.1303584

Zobrazit plný text záznamu

Enhanced cytotoxicity and decreased CD8 dependence of human cancer-specific cytotoxic T lymphocytes after vaccination with low peptide dose

Autor: Philippe Guillaume, Nathalie Rufer, Petra Baumgaertner, Daniel E. Speiser, Tanja Lövgren, Sébastien Wieckowski, Estelle Devevre, Immanuel F. Luescher

Publikováno v: Cancer immunology immunotherapy : CII
Cancer Immunology, Immunotherapy
Cancer Immunology, Immunotherapy, Springer Verlag, 2012, 61 (6), pp.817-826. ⟨10.1007/s00262-011-1140-1⟩
Cancer Immunology, Immunotherapy, vol. 61, no. 6, pp. 817-826

International audience; In mice, vaccination with high peptide doses generates higher frequencies of specific CD8+ T cells, but with lower avidity compared to vaccination with lower peptide doses. To investigate the impact of peptide dose on CD8+ T c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1521b0ac58433d34d42c4436bc2f13fb

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání