Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Sébastien Trop"'
Autor:
Peter Dodek, Lehana Thabane, Arnold S. Kristof, Michael G. Surette, Joanna C. Dionne, Francois Lamontagne, Ryan Zarychanski, James Kutsogiannis, Lauralyn McIntyre, David Williamson, Daniel Ovakim, Diane Heels-Ansdell, François Lauzier, Daphnée Lamarche, Dave Nagpal, Deborah J. Cook, Henry T. Stelfox, Neill K. J. Adhikari, Daniel J. Niven, Robert Cirone, Frédérick D’Aragon, Sangeeta Mehta, Rodrigo Cartin-Ceba, Erick Duan, François Marquis, Charles St-Arnaud, Alberto Goffi, Paul Hosek, Eyal Golan, Osama Loubani, Kosar Khwaja, William R. Henderson, Jan O. Friedrich, Maureen O. Meade, John Granton, Jennifer L Y Tsang, Robert W. Taylor, Paul J Lysecki, John Muscedere, Yaseen M. Arabi, Endotracheal Colonization Trial (Prospect) Investigators, Tim Karachi, Richard I. Hall, M. Elizabeth Wilcox, Nicole Zytaruk, John Marshall, François Lellouche, Alexandra Binnie, Jennie Johnstone, Patrick Archambault, Martin Girard, Margaret S. Herridge, Wendy I. Sligl, Bram Rochwerg, Gordon Wood, Ian M Ball, Shane W. English, Emmanuel Charbonney, Sébastien Trop, Steve Reynolds, Brenda Reeve, Bojan Paunovic, Pierre Aslanian
Publikováno v:
JAMA
IMPORTANCE: Growing interest in microbial dysbiosis during critical illness has raised questions about the therapeutic potential of microbiome modification with probiotics. Prior randomized trials in this population suggest that probiotics reduce inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa8a22eaae318879ac8839d5ef75cd02
https://europepmc.org/articles/PMC8456390/
https://europepmc.org/articles/PMC8456390/
Publikováno v:
Stem Cells (Dayton, Ohio)
The clinical application of hematopoietic progenitor cell-based therapies for the treatment of hematological diseases is hindered by current protocols, which are cumbersome and have limited efficacy to augment the progenitor cell pool. We report that
Publikováno v:
The Journal of Immunology. 166:5044-5050
In early CD4(-)CD8(-) pro-thymocytes, signaling through the pre-TCR is crucial for survival and differentiation into CD4(+)CD8(+) cells. At this more mature stage, interactions between alphabetaTCR and self-Ag/MHC complexes in turn lead either to cel
Publikováno v:
Blood. 97:2269-2277
Cytokines play an essential role during early T-cell development. However, the mechanisms controlling cytokine signaling in developing thymocytes have not been elucidated. Cytokine receptor signaling can be modulated by suppressor of cytokine signali
Autor:
Jennifer L. Y. Tsang, MD, PhD, Alexandra Binnie, MD, DPhil, Erick H. Duan, MD, MSc, Jennie Johnstone, MD, PhD, Diane Heels-Ansdell, MSc, Brenda Reeve, MD, Sebastien Trop, MD, PhD, Paul Hosek, MD, Joanna C. Dionne, MD, PhD, Patrick Archambault, MD, MSc, Paul Lysecki, MD, Robert Cirone, MD, Nicole L. Zytaruk, RN, William Dechert, MSc, Mercedes Peñuela Camargo, MSc, Rebecca Jesso, MN, NP, Elliot McMillan, RN, PhD, Zaynab Panchbhaya, MSN, Tracy Campbell, MSc, Lois Saunders, Mary Copland, BA, Kanthi Kavikondala, BSc, Deborah J. Cook, MD, MSc, for the Probiotics: Prevention of Severe Pneumonia and Endotracheal Colonization Trial (PROSPECT) Investigators and the Canadian Critical Care Trials Group
Publikováno v:
Critical Care Explorations, Vol 4, Iss 11, p e0794 (2022)
OBJECTIVES:. Clinical research in Canada is conducted primarily in “academic” hospitals, whereas most clinical care is provided in “community” hospitals. The objective of this nested observational study was to compare patient characteristics,
Externí odkaz:
https://doaj.org/article/c781643aac0141a28976bc1239c80221
Publikováno v:
The Journal of Immunology. 165:5566-5572
During αβ T cell development, CD4−CD8− thymocytes first express pre-TCR (pTα/TCR-β) before their differentiation to the CD4+CD8+ stage. Positive selection of self-tolerant T cells is then determined by the αβ TCR expressed on CD4+CD8+ thymo
Autor:
Michele Rhodes, Marc A. Berger, David L. Wiest, J. Michael Sauder, Roland L. Dunbrack, Patrice Hugo, Michael Carleton, Sébastien Trop
Publikováno v:
International Immunology. 12:1579-1591
We have identified a novel pre-TCR isoform that is structurally distinct from conventional pre-TCR complexes and whose TCR beta chains are inaccessible to anti-TCR beta antibodies. We term this pre-TCR isoform the MB (masked beta)-pre-TCR. Pre-T alph
Publikováno v:
European Journal of Immunology. 29:2187-2196
Signals delivered through the pre-TCR, a heterodimer of pT alpha and TCR beta chains, are crucial for the maturation and proliferation of immature alphabeta lineage thymocytes from the CD4- CD8- to the CD4+ CD8+ stage. To gain insight into the struct
Publikováno v:
The Journal of Experimental Medicine
The first checkpoint in T cell development occurs between the CD4−CD8− and CD4+CD8+ stages and is associated with formation of the pre-T cell receptor (TCR). The signaling mechanisms that drive this progression remain largely unknown. Here, we sh
Publikováno v:
The Annals of Thoracic Surgery. 84:648-650
Nontraumatic esophageal-atrial fistulas are usually fatal and are diagnosed postmortem. We report a rare case of intraoperative diagnosis and successful surgical management of an esophageal-left atrial fistula in a 70-year-old woman with a history of