Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Sébastien Trop"'
Autor:
Peter Dodek, Lehana Thabane, Arnold S. Kristof, Michael G. Surette, Joanna C. Dionne, Francois Lamontagne, Ryan Zarychanski, James Kutsogiannis, Lauralyn McIntyre, David Williamson, Daniel Ovakim, Diane Heels-Ansdell, François Lauzier, Daphnée Lamarche, Dave Nagpal, Deborah J. Cook, Henry T. Stelfox, Neill K. J. Adhikari, Daniel J. Niven, Robert Cirone, Frédérick D’Aragon, Sangeeta Mehta, Rodrigo Cartin-Ceba, Erick Duan, François Marquis, Charles St-Arnaud, Alberto Goffi, Paul Hosek, Eyal Golan, Osama Loubani, Kosar Khwaja, William R. Henderson, Jan O. Friedrich, Maureen O. Meade, John Granton, Jennifer L Y Tsang, Robert W. Taylor, Paul J Lysecki, John Muscedere, Yaseen M. Arabi, Endotracheal Colonization Trial (Prospect) Investigators, Tim Karachi, Richard I. Hall, M. Elizabeth Wilcox, Nicole Zytaruk, John Marshall, François Lellouche, Alexandra Binnie, Jennie Johnstone, Patrick Archambault, Martin Girard, Margaret S. Herridge, Wendy I. Sligl, Bram Rochwerg, Gordon Wood, Ian M Ball, Shane W. English, Emmanuel Charbonney, Sébastien Trop, Steve Reynolds, Brenda Reeve, Bojan Paunovic, Pierre Aslanian
Publikováno v:
JAMA
IMPORTANCE: Growing interest in microbial dysbiosis during critical illness has raised questions about the therapeutic potential of microbiome modification with probiotics. Prior randomized trials in this population suggest that probiotics reduce inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa8a22eaae318879ac8839d5ef75cd02
https://europepmc.org/articles/PMC8456390/
https://europepmc.org/articles/PMC8456390/
Publikováno v:
Stem Cells (Dayton, Ohio)
The clinical application of hematopoietic progenitor cell-based therapies for the treatment of hematological diseases is hindered by current protocols, which are cumbersome and have limited efficacy to augment the progenitor cell pool. We report that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f265e702f7e563a802a74db4925395f
http://europepmc.org/articles/PMC3593175
http://europepmc.org/articles/PMC3593175
Publikováno v:
Blood. 97:2269-2277
Cytokines play an essential role during early T-cell development. However, the mechanisms controlling cytokine signaling in developing thymocytes have not been elucidated. Cytokine receptor signaling can be modulated by suppressor of cytokine signali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24eb4ef80019ee6d91cfbebb28f4d9bf
https://doi.org/10.1182/blood.v97.8.2269
https://doi.org/10.1182/blood.v97.8.2269
Publikováno v:
The Journal of Immunology. 166:5044-5050
In early CD4(-)CD8(-) pro-thymocytes, signaling through the pre-TCR is crucial for survival and differentiation into CD4(+)CD8(+) cells. At this more mature stage, interactions between alphabetaTCR and self-Ag/MHC complexes in turn lead either to cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61a9cf66f3f69ea049ce1c450e6923a4
https://doi.org/10.4049/jimmunol.166.8.5044
https://doi.org/10.4049/jimmunol.166.8.5044
Publikováno v:
The Journal of Immunology. 165:5566-5572
During αβ T cell development, CD4−CD8− thymocytes first express pre-TCR (pTα/TCR-β) before their differentiation to the CD4+CD8+ stage. Positive selection of self-tolerant T cells is then determined by the αβ TCR expressed on CD4+CD8+ thymo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0704c794c644567ab6d2c6f90e38c452
https://doi.org/10.4049/jimmunol.165.10.5566
https://doi.org/10.4049/jimmunol.165.10.5566
Autor:
Michele Rhodes, Marc A. Berger, David L. Wiest, J. Michael Sauder, Roland L. Dunbrack, Patrice Hugo, Michael Carleton, Sébastien Trop
Publikováno v:
International Immunology. 12:1579-1591
We have identified a novel pre-TCR isoform that is structurally distinct from conventional pre-TCR complexes and whose TCR beta chains are inaccessible to anti-TCR beta antibodies. We term this pre-TCR isoform the MB (masked beta)-pre-TCR. Pre-T alph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e8bc138f09c1b189e2d86454a6c9e28
https://doi.org/10.1093/intimm/12.11.1579
https://doi.org/10.1093/intimm/12.11.1579
Publikováno v:
European Journal of Immunology. 29:2187-2196
Signals delivered through the pre-TCR, a heterodimer of pT alpha and TCR beta chains, are crucial for the maturation and proliferation of immature alphabeta lineage thymocytes from the CD4- CD8- to the CD4+ CD8+ stage. To gain insight into the struct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87e5d8f487bc0f8f3ce6d903c3fc9dbf
https://doi.org/10.1002/(sici)1521-4141(199907)29:07<2187::aid-immu2187>3.0.co
https://doi.org/10.1002/(sici)1521-4141(199907)29:07<2187::aid-immu2187>3.0.co
Publikováno v:
The Journal of Experimental Medicine
The first checkpoint in T cell development occurs between the CD4−CD8− and CD4+CD8+ stages and is associated with formation of the pre-T cell receptor (TCR). The signaling mechanisms that drive this progression remain largely unknown. Here, we sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c133dfd5a13f333e48d60eebca289c84
http://europepmc.org/articles/PMC2195734
http://europepmc.org/articles/PMC2195734
Publikováno v:
The Annals of Thoracic Surgery. 84:648-650
Nontraumatic esophageal-atrial fistulas are usually fatal and are diagnosed postmortem. We report a rare case of intraoperative diagnosis and successful surgical management of an esophageal-left atrial fistula in a 70-year-old woman with a history of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4410e6938fb2274ee752e91e88366666
https://doi.org/10.1016/j.athoracsur.2007.02.091
https://doi.org/10.1016/j.athoracsur.2007.02.091
Autor:
Jennifer L. Y. Tsang, MD, PhD, Alexandra Binnie, MD, DPhil, Erick H. Duan, MD, MSc, Jennie Johnstone, MD, PhD, Diane Heels-Ansdell, MSc, Brenda Reeve, MD, Sebastien Trop, MD, PhD, Paul Hosek, MD, Joanna C. Dionne, MD, PhD, Patrick Archambault, MD, MSc, Paul Lysecki, MD, Robert Cirone, MD, Nicole L. Zytaruk, RN, William Dechert, MSc, Mercedes Peñuela Camargo, MSc, Rebecca Jesso, MN, NP, Elliot McMillan, RN, PhD, Zaynab Panchbhaya, MSN, Tracy Campbell, MSc, Lois Saunders, Mary Copland, BA, Kanthi Kavikondala, BSc, Deborah J. Cook, MD, MSc, for the Probiotics: Prevention of Severe Pneumonia and Endotracheal Colonization Trial (PROSPECT) Investigators and the Canadian Critical Care Trials Group
Publikováno v:
Critical Care Explorations, Vol 4, Iss 11, p e0794 (2022)
OBJECTIVES:. Clinical research in Canada is conducted primarily in “academic” hospitals, whereas most clinical care is provided in “community” hospitals. The objective of this nested observational study was to compare patient characteristics,
Externí odkaz:
https://doaj.org/article/c781643aac0141a28976bc1239c80221