Synthesis and In Vitro Comparison of DOTA, NODAGA and 15-5 Macrocycles as Chelators for the 64Cu-Labelling of Immunoconjugates

Autor: Aurélie Maisonial-Besset, Tiffany Witkowski, Mercedes Quintana, Sophie Besse, Vincent Gaumet, Axel Cordonnier, Cyrille Alliot, Aurélien Vidal, Caroline Denevault-Sabourin, Sébastien Tarrit, Sophie Levesque, Elisabeth Miot-Noirault, Jean-Michel Chezal

Publikováno v: Molecules, Vol 28, Iss 1, p 75 (2022)

The development of 64Cu-based immuno-PET radiotracers requires the use of copper-specific bifunctional chelators (BFCs) that contain functional groups allowing both convenient bioconjugation and stable copper complexes to limit in vivo bioreduction,

Externí odkaz: https://doaj.org/article/89ab06b2726f431d8c2c4fbde3d019d8

Synthesis and in vitro preliminary evaluation of prostate-specific membrane antigen targeted upconversion nanoparticles as a first step towards radio/fluorescence-guided surgery of prostate cancer

Autor: Tiffany Witkowski, Jean-Michel Chezal, Frédérique Penault-Llorca, Françoise Degoul, Damien Boyer, Mhammed Benbakkar, Leslie Mazuel, Aurélie Maisonial-Besset, Axel Cordonnier, Magali Vivier, Sébastien Tarrit, Arnaud Briat, Rodolphe Valleix, Elisabeth Miot-Noirault, Sophie Besse, Benoît Maunit, Mercedes Quintana, Rachid Mahiou

Publikováno v: Journal of materials chemistry‎ B
Journal of materials chemistry‎ B, Royal Society of Chemistry, 2021, 9, pp.7423-7434. ⟨10.1039/D1TB00777G⟩
Journal of materials chemistry‎ B, Royal Society of Chemistry, In press, ⟨10.1039/D1TB00777G⟩
Journal of materials chemistry‎ B, Royal Society of Chemistry, 2021, ⟨10.1039/d1tb00777g⟩
Journal of materials chemistry‎ B, 2021, 9, pp.7423-7434. ⟨10.1039/D1TB00777G⟩

International audience; Over the last decade, upconversion nanoparticles (UCNP) have been widely investigated in nanomedicine due to their high potential as imaging agents in the near-infrared (NIR) optical window of biological tissues. Here, we succ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5d03c56f5d9817cf8b45e254b08f614
https://doi.org/10.1039/d1tb00777g

Comparative evaluation by SPECT and PET imaging of two immuno-pre-targeting systems in an in vivo model of triple negative breast tumours with anti-EGFR antibodies

Autor: Arnaud Briat, Sébastien Schmitt, Sophie Besse, Marine Delmas, Nancy Ty, Sébastien Tarrit, Mercedes Quintana, Elisabeth Miot-Noirault, Emmanuel Moreau

Publikováno v: Nuclear Medicine and Biology. :S204-S205

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::458fbad4977dacdf3ca18dab0c73ca6c
https://doi.org/10.1016/s0969-8051(22)00421-8

Green HPLC quantification method of lamivudine, zidovudine and nevirapine with identification of related substances in tablets

Autor: Ludivine Vieira-Sellaï, Mercedes Quintana, Ousmane Diop, Olivier Mercier, Sebastien Tarrit, Nawal Raimi, Alassan Ba, Benoit Maunit, Marie-Josephe Galmier

Publikováno v: Green Chemistry Letters and Reviews, Vol 15, Iss 3, Pp 695-704 (2022)

A green HPLC method for lamivudine (3TC), zidovudine (AZT) and nevirapine (NVP) determination in fixed-dose combination tablets was developed using ethanol as both one of the mobile phases and the solvent for sample preparation. This method was valid

Externí odkaz: https://doaj.org/article/0090101215b540ad8a4f23944c6ae9d2

Synthesis, radiolabeling and preliminary in vivo evaluation of multimodal radiotracers for PET imaging and targeted radionuclide therapy of pigmented melanoma

Autor: Sébastien Tarrit, Bertrand Kuhnast, Elisabeth Miot-Noirault, Marie-Josèphe Galmier, Jean-Baptiste Béquignat, Aurélie Maisonial-Besset, Françoise Degoul, Emilie M. F. Billaud, Latifa Rbah-Vidal, Aurélien Vidal, Frédéric Dollé, Caroline Decombat, Jean-Bernard Deloye, Jean-Claude Madelmont, Philippe Auzeloux, Jean-Michel Chezal, Laurent Audin, Michèle Borel, Sophie Besse

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, 2015, 92, pp.818-838. ⟨10.1016/j.ejmech.2015.01.034⟩
European Journal of Medicinal Chemistry, Elsevier, 2015, 92, pp.818-838. ⟨10.1016/j.ejmech.2015.01.034⟩

Melanin pigment represents an attractive target to address specific treatment to melanoma cells, such as cytotoxic radionuclides. However, less than half of the patients have pigmented metastases. Hence, specific marker is required to stratify this p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55132b9ad01cbd5975808907381886a6
https://hal.science/hal-01677566