Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Sébastien Soubeyrand"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Tribbles related homolog 1 (TRIB1) contributes to lipid and glucose homeostasis by facilitating the degradation of cognate cargos by the proteasome. In view of the key metabolic role of TRIB1 and the impact of proteasome inhibition on hepati
Externí odkaz:
https://doaj.org/article/87eba89f58c947f49177a8deab6086fc
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract We previously identified genomic variants that are quantitative trait loci for circulating miR-1908-5p and then showed this microRNA to causally associate with plasma levels of LDL-C, fasting blood glucose and HbA1c. The link to LDL-C was su
Externí odkaz:
https://doaj.org/article/c87a1a21cb334eb79ff13e51ea95ad5f
Autor:
Sébastien Soubeyrand, Majid Nikpay, Paulina Lau, Adam Turner, Huy-Dung Hoang, Tommy Alain, Ruth McPherson
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
Genome-wide association studies have identified several genetic loci linked to coronary artery disease (CAD) most of them located in non-protein coding regions of the genome. One such locus is the CAD Associated Region between MFGE8 and ABHD2 (CARMA)
Externí odkaz:
https://doaj.org/article/d637ea2066f04207bfd94f3c11cf97ed
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract The TRIB1 locus has been linked to both cardiovascular disease and hepatic steatosis. Recent efforts have revealed TRIB1 to be a major regulator of liver function, largely, but not exclusively, via CEBPA degradation. We recently uncovered a
Externí odkaz:
https://doaj.org/article/3ef6b6c9fa4342a49ea9bf015bfea87b
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0224113 (2019)
Inactive fusion variants of the CRISPR-Cas9 system are increasingly being used as standard methodology to study transcription regulation. Their ability to readily manipulate the native genomic loci is particularly advantageous. In this work, we seren
Externí odkaz:
https://doaj.org/article/851c2d397f754fe8800ac7a7f73eba69
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0152346 (2016)
The TRIB1 gene has been associated with multiple malignancies, plasma triglycerides and coronary artery disease (CAD). Despite the clinical significance of this pseudo-kinase, there is little information on the regulation of TRIB1. Previous studies r
Externí odkaz:
https://doaj.org/article/f775e4d20ee14306a081986ccb27a17f
Autor:
Sébastien Soubeyrand, Thomas A. Lagace, Paulina Lau, Kaitlyn Beehler, Majid Nikpay, Ruth McPherson, AnhThu Dang
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 41:2252-2262
Objective: Leveraging microRNA-Seq data and the 1000 Genomes imputed genotypes, we identified rs174561 as a strong microRNA quantitative trait loci for circulating microRNA-1908-5p with higher miR-1908-5p and reduced LDL (low-density lipoprotein)-cho
Publikováno v:
Circulation: Genomic and Precision Medicine. 15
Background: Fibronectin ( FN1 ) is an essential regulator of homodynamic processes and tissue remodeling that have been proposed to contribute to atherosclerosis. Moreover, recent large-scale genome-wide association studies (GWAS) have linked common
Publikováno v:
Atherosclerosis. 304:39-43
Background and aims A 42 year-old male with premature atherosclerosis, severe dyslipidemia and resistance to treatment with high dose statin and a recommended dose of a PCSK9 inhibitor, was found to have a duplication of the PCSK9 gene. However, the
Autor:
Ruth McPherson, Paulina Lau, Katey L Whytock, Kaitlyn Beehler, Chantal A. Pileggi, Sujoy Ghosh, Sébastien Soubeyrand, Majid Nikpay, Robert Dent, Mary-Ellen Harper
Publikováno v:
Diabetes. 69:2017-2026
Technologies to fold structures into compact shapes are required in multiple engineering applications. Earwigs (Dermaptera) fold their fanlike hind wings in a unique, highly sophisticated manner, granting them the most compact wing storage among all