A polyphenol-rich plant extract prevents hypercholesterolemia and modulates gut microbiota in western diet-fed mice

Autor: Cédric Langhi, Marie Vallier, Auriane Bron, Yolanda F. Otero, Maheva Maura, Florian Le Joubioux, Niek Blomberg, Martin Giera, Bruno Guigas, Thierry Maugard, Benoit Chassaing, Sébastien Peltier, Stéphanie Blanquet-Diot, Jean-Marie Bard, Pascal Sirvent

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 11 (2024)

IntroductionTotum-070 is a combination of five plant extracts enriched in polyphenols to target hypercholesterolemia, one of the main risk factors for cardiovascular diseases. The aim of this study was to investigate the effects of Totum-070 on chole

Externí odkaz: https://doaj.org/article/fd059bc1b2854f0aacd7c89732c3df30

Abstract 10461: Totum-854 Lowers Blood Pressure in L-NAME-Induced Arterial Hypertension in Mice and in Spontaneous Hypertensive Rat Model

Autor: Gaetan Bolea, Doriane Ripoche, Gregory MEYER, Florian Le Joubioux, Arnaud Michaux, Yolanda F OTERO, Sébastien PELTIER, Pascal SIRVENT, Cyril REBOUL

Publikováno v: Circulation. 144

Introduction: Arterial Hypertension (AHT) is a major cause of premature death worldwide. We have developed Totum-854 (T-854), a polyphenol-rich botanical composition to reduce the risk of developing AHT. We assessed the chronic effect of T-854 on pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::75d7a6d2dcdca93ca9fadeeffa19c34e
https://doi.org/10.1161/circ.144.suppl_1.10461

Effects of a novel polyphenol-rich plant extract on body composition, inflammation, insulin sensitivity, and glucose homeostasis in obese mice

Autor: Owen P. McGuinness, Vivien Chavanelle, Pascal Sirvent, Martin Giera, Joost M. Lambooij, Yolanda F. Otero, Hendrik J. P. van der Zande, Louise Lantier, Sébastien Peltier, Florian Le Joubioux, Frank Otto, Anna Zawistowska-Deniziak, Thierry Maugard, Bruno Guigas

Publikováno v: International Journal of Obesity
International Journal of Obesity, Nature Publishing Group, 2021, 45 (9), pp.2016-2027. ⟨10.1038/s41366-021-00870-x⟩
International Journal of Obesity. SPRINGERNATURE

Background/objectives The worldwide prevalence of obesity, metabolic syndrome and type 2 diabetes (T2D) is reaching epidemic proportions that urge the development of new management strategies. Totum-63 is a novel, plant-based polyphenol-rich active p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a82f45c5a0ca20b236ffdebe5b144073
https://hal-univ-rochelle.archives-ouvertes.fr/hal-03501537

Effects of Totum-63 on glucose homeostasis and post-prandial glycemia: a translational study

Autor: Christophe Montaurier, Gisèle Pickering, Yolanda F. Otero, Geoffroy Marceau, Florian Le Joubioux, Gilles Ducheix, M. Bargetto, Pascal Sirvent, Vincent Sapin, Aurore Vluggens, Claude Dubray, Doriane Ripoche, Bruno Guigas, Murielle Cazaubiel, Sylvia Boulliau, Nathalie Boisseau, Vivien Chavanelle, Nicolas Macian, Sébastien Peltier, Thierry Maugard, Frédéric Dutheil, Christian Dualé

Publikováno v: AJP-Endocrinology and Metabolism, 320(6), E1119-E1137. AMER PHYSIOLOGICAL SOC
AJP-Endocrinology and Metabolism
AJP-Endocrinology and Metabolism, American Physiological Society, 2021, 320 (6), pp.E1119-E1137. ⟨10.1152/ajpendo.00629.2020⟩
AJP-Endocrinology and Metabolism, 2021, 320 (6), pp.E1119-E1137. ⟨10.1152/ajpendo.00629.2020⟩
Am J Physiol Endocrinol Metab

International audience; Global prevalence of type 2 diabetes (T2D) is rising and may affect 700 million people by 2045. Totum-63 is a polyphenol-rich natural composition developed to reduce the risk of T2D. We first investigated the effects of Totum-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96ae3c9f6d3cf112159b05e20a89f60a
http://hdl.handle.net/20.500.12278/29421

848-P: Totum-63 Lowers Fasting Glycemia in Subjects with Prediabetes: A Phase 2A Clinical Trial

Autor: Sébastien Peltier, Pascal Sirvent, Bruno Pereira, Yolanda F. Otero, Vivien Chavanelle, M. Bargetto, Murielle Cazaubiel, Jean-Marie Bard

Publikováno v: Diabetes. 69

Over 1 billion people worldwide suffer prediabetes, which is defined by increased fasting blood glucose (FBG), glucose intolerance and/or higher A1c hemoglobin. Prediabetes is considered a risk factor for type 2 diabetes (T2D). We have developed Totu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6eaa8d8007b003b975cbe5a201513880
https://doi.org/10.2337/db20-848-p