Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Sébastien P Dion"'
Publikováno v:
PLoS ONE, Vol 17, Iss 8, p e0273825 (2022)
TMPRSS6 is a type II transmembrane serine protease involved in iron homeostasis expressed as 4 isoforms in humans. TMPRSS6 isoform 2 downregulates hepcidin production by cleaving hemojuvelin and other surface proteins of hepatocytes. The functions of
Externí odkaz:
https://doaj.org/article/59be08b264514d2e81747bc264b43c0a
Autor:
Kelcie A Lahey, Natalie J Ronaghan, Judie Shang, Sébastien P Dion, Antoine Désilets, Richard Leduc, Wallace K MacNaughton
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180259 (2017)
Changes in barrier function of the gastrointestinal tract are thought to contribute to the inflammatory bowel diseases Crohn's disease and ulcerative colitis. Previous work in our lab demonstrated that apical exposure of intestinal epithelial cell li
Externí odkaz:
https://doaj.org/article/b44bc67df142412d959c2b40a2030a9f
Autor:
Tirosh Shapira, I. Abrrey Monreal, Sébastien P. Dion, David W. Buchholz, Brian Imbiakha, Andrea D. Olmstead, Mason Jager, Antoine Désilets, Guang Gao, Mathias Martins, Thierry Vandal, Connor A. H. Thompson, Aaleigha Chin, William D. Rees, Theodore Steiner, Ivan Robert Nabi, Eric Marsault, Julie Sahler, Diego G. Diel, Gerlinde R. Van de Walle, Avery August, Gary R. Whittaker, Pierre-Luc Boudreault, Richard Leduc, Hector C. Aguilar, François Jean
Publikováno v:
Nature. 605:340-348
The COVID-19 pandemic caused by the SARS-CoV-2 virus remains a global public health crisis. Although widespread vaccination campaigns are underway, their efficacy is reduced owing to emerging variants of concern1,2. Development of host-directed thera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db9dca545d7fbe19dcbebd61e81a4589
https://doi.org/10.1038/s41586-022-04661-w
https://doi.org/10.1038/s41586-022-04661-w
Autor:
Sébastien P. Dion, Alexandre Murza, Pierre-Luc Boudreault, Eric Marsault, Richard Leduc, Antoine Désilets
Publikováno v:
Expert Opinion on Therapeutic Patents
Type II transmembrane serine proteases (TTSPs) of the human respiratory tract generate high interest owing to their ability, among other roles, to cleave surface proteins of respiratory viruses. This step is critical in the viral invasion of coronavi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::773961ec6ac364fd6b22d9272870375e
https://doi.org/10.1080/13543776.2020.1817390
https://doi.org/10.1080/13543776.2020.1817390
Autor:
Theodore S. Steiner, Guang Gao, Brian Imbiakha, Aaleigha Chin, Sébastien P. Dion, Julie Sahler, Eric Marsault, Ivan R. Nabi, Avery August, François Jean, I. Abrrey Monreal, Hector C. Aguilar, Antoine Désilets, Andrea D. Olmstead, David W. Buchholz, Gerlinde R. Van de Walle, Pierre-Luc Boudreault, Richard Leduc, Mason Jager, William Rees, Tirosh Shapira, Gary R. Whittaker, Thierry Vandal
Publikováno v:
bioRxiv
SummaryThe COVID-19 pandemic caused by the SARS-CoV-2 virus remains a global public health crisis. Although widespread vaccination campaigns are underway, their efficacy is reduced against emerging variants of concern (VOCs) 1,2. Development of host-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1797ed55d168713c66471069b5fddec
https://europepmc.org/articles/PMC8109206/
https://europepmc.org/articles/PMC8109206/
Autor:
François Béliveau, Antoine Désilets, Mariana Gabriela Ghinet, Sébastien P. Dion, Richard Leduc
Publikováno v:
Journal of Cellular and Molecular Medicine
TMPRSS6 (matriptase‐2) is a type II transmembrane serine protease involved in iron homoeostasis. At the cell surface of hepatocytes, TMPRSS6 cleaves haemojuvelin (HJV) and regulates the BMP/SMAD signalling pathway leading to production of hepcidin,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c01b4764f31b2f76af6a43482f7bfd4
http://europepmc.org/articles/PMC5867103
http://europepmc.org/articles/PMC5867103
Autor:
Raza S. Zaheer, Jerrold R. Turner, Natalie Ronaghan, Pina Colarusso, Richard Leduc, Wallace K. MacNaughton, Judie Shang, Antoine Désilets, Vadim Iablokov, Sébastien P. Dion
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 311:G466-G479
Barrier dysfunction is a characteristic of the inflammatory bowel diseases (IBD), Crohn's disease and ulcerative colitis. Understanding how the tight junction is modified to maintain barrier function may provide avenues for treatment of IBD. We have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63efc14b2540b2a5dd50998e3379bf3f
https://doi.org/10.1152/ajpgi.00441.2015
https://doi.org/10.1152/ajpgi.00441.2015
Autor:
Sébastien P. Dion, Rafael Najmanovich, François Béliveau, Richard Leduc, Louis-Philippe Morency, Antoine Désilets
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Scientific Reports
Scientific Reports
TMPRSS6, also known as matriptase-2, is a type II transmembrane serine protease that plays a major role in iron homeostasis by acting as a negative regulator of hepcidin production through cleavage of the BMP co-receptor haemojuvelin. Iron-refractory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::079f5835f8f75bfc4ed1ecea883adb6f
https://doi.org/10.1038/s41598-018-30618-z
https://doi.org/10.1038/s41598-018-30618-z
Autor:
Antoine Désilets, Richard Leduc, Wallace K. MacNaughton, Sébastien P. Dion, Judie Shang, Natalie Ronaghan, Kelcie Lahey
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 7, p e0180259 (2017)
PLoS ONE, Vol 12, Iss 7, p e0180259 (2017)
Changes in barrier function of the gastrointestinal tract are thought to contribute to the inflammatory bowel diseases Crohn's disease and ulcerative colitis. Previous work in our lab demonstrated that apical exposure of intestinal epithelial cell li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b61154fdec0d55b2de6018f271bbd26
http://europepmc.org/articles/PMC5495298
http://europepmc.org/articles/PMC5495298
Autor:
Eric Marsault, Pierre-Luc Boudreault, Richard Leduc, Éloïc Colombo, François Béliveau, Sébastien P. Dion, Catherine St-Georges, Rafael Najmanovich, Mariana Gabriela Ghinet, Antoine Désilets
Publikováno v:
European journal of medicinal chemistry. 129
Matriptase-2, a type II transmembrane serine protease (TTSP), is expressed in the liver and regulates iron homeostasis via the cleavage of hemojuvelin. Matriptase-2 emerges as an attractive target for the treatment of conditions associated with iron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::829e4195da664856075c49bc17aa78c1
https://pubmed.ncbi.nlm.nih.gov/28219045
https://pubmed.ncbi.nlm.nih.gov/28219045