Výsledky vyhledávání - "Sébastien P Blais"

Akademický článek

tRNAGlu increases the affinity of glutamyl-tRNA synthetase for its inhibitor glutamyl-sulfamoyl-adenosine, an analogue of the aminoacylation reaction intermediate glutamyl-AMP: mechanistic and evolutionary implications.

Autor: Sébastien P Blais, Jack A Kornblatt, Xavier Barbeau, Guillaume Bonnaure, Patrick Lagüe, Robert Chênevert, Jacques Lapointe

Publikováno v: PLoS ONE, Vol 10, Iss 4, p e0121043 (2015)

For tRNA-dependent protein biosynthesis, amino acids are first activated by aminoacyl-tRNA synthetases (aaRSs) yielding the reaction intermediates aminoacyl-AMP (aa-AMP). Stable analogues of aa-AMP, such as aminoacyl-sulfamoyl-adenosines, inhibit the

Externí odkaz: https://doaj.org/article/3b1d561ac2e54987ae808045ca1ea8dc

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Inhibition ofHelicobacter pyloriGlu-tRNAGlnamidotransferase by novel analogues of the putative transamidation intermediate

Autor: Paul H. Roy, Sébastien P. Blais, Christian Balg, Normand Voyer, Robert Chênevert, Jacques Lapointe, Halim Maaroufi, Nancy Messier, Van Hau Pham, François Otis

Publikováno v: FEBS Letters. 590:3335-3345

Glutaminyl-tRNAGln in Helicobacter pylori is formed by an indirect route requiring a noncanonical glutamyl-tRNA synthetase and a tRNA-dependent heterotrimeric amidotransferase (AdT) GatCAB. Widespread use of this pathway among prominent human pathoge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a144e3dc88691cfbc941e34dac56595
https://doi.org/10.1002/1873-3468.12380

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Cardiac Implantable Electronic Device Infection: Detailed Analysis of Cost Implications

Autor: François Philippon, Frédéric Jacques, Sébastien P. Blais, Edouard Gitenay, Hélène Parent, Franck Molin, Jean Champagne, Philippe Gervais, Véronique Tremblay, Benoit Plourde, Gilles O'Hara, Jean-François Sarrazin, Eric Charbonneau, Christian Steinberg

Publikováno v: The Canadian journal of cardiology. 34(8)

Background Infections of cardiac implantable electronic devices (CIED) are associated with significant morbidity and mortality. Despite many preventive measures, this condition is associated with significant costs for the health care system. Methods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6afc8d3145aaaa1ed69f9faf5e89ad66
https://pubmed.ncbi.nlm.nih.gov/30049357

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Cost-effectiveness of FreeO2 in patients with chronic obstructive pulmonary disease hospitalised for acute exacerbations: analysis of a pilot study in Quebec

Autor: Christian R.C. Kouakou, Véronique Tremblay, Sébastien P. Blais, Thomas G. Poder, François Maltais, Pierre-Alexandre Bouchard, François Lellouche

Publikováno v: BMJ Open

ObjectiveConduct a cost-effectiveness analysis of FreeO2technology versus manual oxygen-titration technology for patients with chronic obstructive pulmonary disease (COPD) hospitalised for acute exacerbations.SettingTertiary acute care hospital in Qu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b22b5bd28db4faa9309b86b7ce50c8ae
http://europepmc.org/articles/PMC5786115

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Correction: tRNAGlu Increases the Affinity of Glutamyl-tRNA Synthetase for Its Inhibitor Glutamyl-Sulfamoyl-Adenosine, an Analogue of the Aminoacylation Reaction Intermediate Glutamyl-AMP: Mechanistic and Evolutionary Implications

Autor: Robert Chênevert, Jack A. Kornblatt, Guillaume Bonnaure, Jacques Lapointe, Patrick Lagüe, Sébastien P. Blais, Xavier Barbeau

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0130238 (2015)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c03a2585603344052fb5437b2540c9
http://europepmc.org/articles/PMC4454567?pdf=render

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A Weak Fe–O Bond in the Oxygenated Complex of the Nitric-oxide Synthase of Staphylococcus aureus

Autor: Manon Couture, Sébastien P. Blais, François J.M. Chartier

Publikováno v: Journal of Biological Chemistry. 281:9953-9962

Little is known about the intermediates formed during catalysis by nitric-oxide synthase (NOS). We report here the characterization by resonance Raman spectroscopy of the oxygenated complex of the NOS from Staphylococcus aureus (saNOS) as well as the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c50a62e8f35e7692269d323b62605e31
https://doi.org/10.1074/jbc.m513893200

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Inhibition of Helicobacter pylori aminoacyl-tRNA amidotransferase by chloramphenicol analogs

Autor: Jonathan L. Huot, Christian Balg, Robert Chênevert, Sébastien P. Blais, Jacques Lapointe, Maria De Mieri

Publikováno v: Bioorganicmedicinal chemistry. 18(22)

Genomic studies revealed the absence of glutaminyl-tRNA synthetase and/or asparaginyl-tRNA synthetase in many bacteria and all known archaea. In these microorganisms, glutaminyl-tRNA(Gln) (Gln-tRNA(Gln)) and/or asparaginyl-tRNA(Asn) (Asn-tRNA(Asn)) a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11667920ef1e2c39d1c3b5f2b0d84b5f
https://pubmed.ncbi.nlm.nih.gov/20943400

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Plasmodial aspartyl-tRNA synthetases and peculiarities in Plasmodium falciparum

Autor: Ermanno Candolfi, Magali Frugier, Tania Bour, Bernard Lorber, Christian Balg, Aziza Akaddar, Sébastien P. Blais

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2009, 284 (28), pp.18893-903. ⟨10.1074/jbc.M109.015297⟩

International audience; Distinctive features of aspartyl-transfer RNA (tRNA) synthetases (AspRS) from the protozoan Plasmodium genus are described. These apicomplexan AspRSs contain 29-31 amino acid insertions in their anticodon binding domains, a re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::384a7dbe63bd8a62d9b78c2963824cd5
https://pubmed.ncbi.nlm.nih.gov/19443655

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