Evolutionary emergence of infectious diseases in heterogeneous host populations.

Autor: Hélène Chabas, Sébastien Lion, Antoine Nicot, Sean Meaden, Stineke van Houte, Sylvain Moineau, Lindi M Wahl, Edze R Westra, Sylvain Gandon

Publikováno v: PLoS Biology, Vol 16, Iss 9, p e2006738 (2018)

The emergence and re-emergence of pathogens remains a major public health concern. Unfortunately, when and where pathogens will (re-)emerge is notoriously difficult to predict, as the erratic nature of those events is reinforced by the stochastic nat

Externí odkaz: https://doaj.org/article/54a86ab65d064ce1a8cf60aa3525630f

Spatial structure, transmission modes and the evolution of viral exploitation strategies.

Autor: Thomas W Berngruber, Sébastien Lion, Sylvain Gandon

Publikováno v: PLoS Pathogens, Vol 11, Iss 4, p e1004810 (2015)

Spatial structure and local migration are predicted to promote the evolution of less aggressive host exploitation strategies in horizontally transmitted pathogens. Here we explore the effect of spatial structure on the evolution of pathogens that can

Externí odkaz: https://doaj.org/article/4cf57b083c2149949a06558d40ba76ae

Effect of unequal vaccination coverage and migration on long-term pathogen evolution in a metapopulation

Autor: Alicia Walter, Sylvain Gandon, Sébastien Lion

Worldwide inequalities in vaccine availability are expected to affect the spread and spatial distribution of infectious diseases. It is unclear, however, how spatial variation in vaccination coverage can affect the long-term evolution of pathogens. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::02d87df28426681ab24bb9bc3e6c3446
https://doi.org/10.1101/2022.12.16.520709

Phenotypic evolution of SARS-CoV-2: a statistical inference approach

Autor: Wakinyan Benhamou, Sébastien Lion, Rémi Choquet, Sylvain Gandon

Since its emergence in late 2019, the SARS-CoV-2 virus has spread globally, causing the ongoing COVID-19 pandemic. In the fall of 2020, the Alpha variant (lineage B.1.1.7) was detected in England and rapidly spread and outcompeted the previous lineag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6858d4ba04066f37df42c6ca964ebd5d
https://doi.org/10.1101/2022.08.25.22279206

An epi‐evolutionary model for predicting the adaptation of spore‐producing pathogens to quantitative resistance in heterogeneous environments

Autor: Ramsès Djidjou-Demasse, Frédéric Fabre, Sébastien Lion, Arnaud Ducrot, Quentin Richard, Jean-Baptiste Burie

Publikováno v: Evolutionary Applications
Evolutionary Applications, 2022, pp.95-110. ⟨10.1111/eva.13328⟩
Evolutionary Applications, Vol 15, Iss 1, Pp 95-110 (2022)
Evolutionary Applications, Blackwell, 2022, ⟨10.1111/eva.13328⟩
Evolutionary Applications, Blackwell, 2021, ⟨10.1111/eva.13328⟩

International audience; We have modeled the evolutionary epidemiology of spore-producing plant pathogens in heterogeneous environments sown with several cultivars carrying quantitative resistances. The model explicitly tracks the infection-age struct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4533270ffe4e02c25c50fd5ce54139b5
https://hal.science/hal-03465168/file/Fabre_EvolApp_2021.pdf