Výsledky vyhledávání - "Sébastien Lethu"

Phosphatidylcholine bearing 6,6-dideuterated oleic acid: A useful solid-state 2H NMR probe for investigating membrane properties

Autor: Nobuaki Matsumori, Fuminori Sato, Tomokazu Yasuda, Shigeru Matsuoka, Sébastien Lethu, Michio Murata, Jin Cui

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 25:203-206

Lipid organization has been at the center of research on lipid rafts. Dioleoylphosphatidylcholine (DOPC) is a typical unsaturated lipid. Very few studies have reported its thermodynamics in raft-like membranes. Herein, we have developed a highly effi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7aa6af889eccbfeeb073799af626fd5
https://doi.org/10.1016/j.bmcl.2014.11.072

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Water-Mediated Recognition of Simple Alkyl Chains by Heart-Type Fatty-Acid-Binding Protein

Autor: Tsuyoshi Inoue, Toshiaki Hara, S. Roy Kimura, Osamu Ichihara, Shigeru Matsuoka, Eiichi Mizohata, Daisuke Matsuoka, Satoshi Murakami, Mika Hirose, Michio Murata, Shigeru Sugiyama, Hanako Ishida, Sébastien Lethu, Hikaru Ano

Publikováno v: Angewandte Chemie (International Ed. in English)

Long-chain fatty acids (FAs) with low water solubility require fatty-acid-binding proteins (FABPs) to transport them from cytoplasm to the mitochondria for energy production. However, the precise mechanism by which these proteins recognize the variou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c017e4b52db289a85130b7b98b176e9
https://doi.org/10.1002/ange.201409830

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Highly Efficient Preparation of Selectively Isotope Cluster-Labeled Long Chain Fatty Acids via Two Consecutive Csp3–Csp3 Cross-Coupling Reactions

Autor: Shigeru Matsuoka, Michio Murata, Sébastien Lethu

Publikováno v: Organic Letters. 16:844-847

An efficient synthesis involving two copper-catalyzed alkyl-alkyl coupling reactions has been designed to easily access doubly isotope-labeled fatty acids. Such NMR- and IR-active compounds were obtained in excellent overall yields and will be furthe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2025b20017837a0af28f7364bdc41430
https://doi.org/10.1021/ol4036159

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Synthesis and Th1-immunostimulatory activity of α-galactosylceramide analogues bearing a halogen-containing or selenium-containing acyl chain

Autor: Michio Murata, Shunsuke Kita, Katsumi Maenaka, Shinya Hanashima, Hiroki Kusaka, Md. Imran Hossain, Hiroshi Tsuchikawa, Sébastien Lethu, Takuto Nomura

Publikováno v: Bioorganicmedicinal chemistry. 24(16)

A novel series of CD1d ligand α-galactosylceramides (α-GalCers) were synthesized by incorporation of the heavy atoms Br and Se in the acyl chain backbone of α-galactosyl-N-cerotoylphytosphingosine. The synthetic analogues are potent CD1d ligands a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b18f156842ab804a957889f350da17b
https://pubmed.ncbi.nlm.nih.gov/27325450

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New protein farnesyltransferase inhibitors in the 3-arylthiophene 2-carboxylic acid series: diversification of the aryl moiety by solid-phase synthesis

Autor: Sébastien Lethu, Elisabeth Mouray, Philippe Grellier, Joëlle Dubois, Damien Bosc

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, Informa Healthcare, 2013, 28 (1), pp.163-71. ⟨10.3109/14756366.2011.643302⟩

International audience; A new synthetic pathway was devised to reach tetrasubstituted 3-arylthiophene 2-carboxylic acids in a three-step solid-phase synthesis. This very efficient methodology provided more than 20 new compounds that were evaluated fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5eb7190e5147c162311103b88b10874
https://doi.org/10.3109/14756366.2011.643302

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SNAr and Palladium-Catalyzed Reactions of Deactivated Thiophene: Application to the Synthesis of Protein Farnesyltransferase Inhibitors

Autor: Joëlle Dubois, Sébastien Lethu

Publikováno v: European Journal of Organic Chemistry. 2011:3920-3931

To investigate the influence of the 5-thioether moiety of our previously identified hit thiophene compound upon protein farnesyltransferase inhibition, we synthesized a new library of 3-(4-chlorophenyl)-4-cyanothiophene-2-carboxylic derivatives throu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c0b6f272c05c13232e214797ed326966
https://doi.org/10.1002/ejoc.201100215

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Discovery of a New Class of Protein Farnesyltransferase Inhibitors in the Arylthiophene Series

Autor: Joëlle Dubois, Maryon Ginisty, Damien Bosc, Sébastien Lethu

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2009, 52 (20), pp.6205-8. ⟨10.1021/jm901280q⟩

International audience; Screening of the ICSN chemical library led to the discovery of 3-(4-chlorophenyl)-4-cyano-5-thioalkylthiophene 2-carboxylic acids as potent farnesyltransferase inhibitors. Enzymatic kinetic studies showed that this original FT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e6802d26828fe8e221a3422e47ca1db
https://doi.org/10.1021/jm901280q

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Stereoselective synthesis of the head group of archaeal phospholipid PGP-Me to investigate bacteriorhodopsin-lipid interactions

Autor: Nobuaki Matsumori, Michio Murata, Yuichi Umegawa, Satoshi Kawatake, Fuminori Sato, Masaki Yamagami, Jin Cui, Sébastien Lethu, Shigeru Matsuoka

Publikováno v: Organicbiomolecular chemistry. 13(41)

Phosphatidylglycerophosphate methyl ester (PGP-Me), a major constituent of the archaeal purple membrane, is essential for the proper proton-pump activity of bacteriorhodopsin (bR). We carried out the first synthesis of the bisphosphate head group of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0f1091e7b9f4e0b01c4ec1863f4d30e
https://pubmed.ncbi.nlm.nih.gov/26442463

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