Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Sébastien Lengelé"'
Autor:
Ledecq Marie, Stéphane Meunier, Benoit Mathieu, Laurent Provins, Christian Wolff, Sébastien Lengelé, Alain Wagner, Anne Frycia, Florence Lebon, Nathalie Bosman, Cecile Pegurier, Kashinath Dhurke, Ananda Kumar Kanduluru
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:3978-3982
A multi-disciplinary approach was used to identify the first pharmacophore model for KCC2 blockers: several physico-chemical studies such as XRD and NMR were combined to molecular modelling techniques, SAR analysis and synthesis of constrained analog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96363e3acf4c347756f357134ed0d1f8
https://doi.org/10.1016/j.bmcl.2012.04.097
https://doi.org/10.1016/j.bmcl.2012.04.097
Autor:
Stéphane Meunier, Laurent Provins, Philippe Collart, Ananda Kumar Kanduluru, Christian Wolff, Marie-Laure Delporte, Alain Wagner, Nathalie Pacico, Sébastien Lengelé, Cecile Pegurier, Lakshmana Rao Vadali, Nathalie Bosman, Karine Leclercq
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:2542-2545
The discovery and optimization of a novel class of selective submicromolar KCC2 blockers is described. Details of synthesis and SAR are given together with ADME properties of selected compounds. A methylsulfone residue on the R(1) phenyl group improv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86469e891c147c719b56e703f7c5b566
https://doi.org/10.1016/j.bmcl.2010.02.092
https://doi.org/10.1016/j.bmcl.2010.02.092