Meg3 Non-coding RNA Expression Controls Imprinting by Preventing Transcriptional Upregulation in cis

Autor: Ildem Sanli, Sébastien Lalevée, Marco Cammisa, Aurélien Perrin, Florence Rage, David Llères, Andrea Riccio, Edouard Bertrand, Robert Feil

Publikováno v: Cell Reports, Vol 23, Iss 2, Pp 337-348 (2018)

Summary: Although many long non-coding RNAs (lncRNAs) are imprinted, their roles often remain unknown. The Dlk1-Dio3 domain expresses the lncRNA Meg3 and multiple microRNAs and small nucleolar RNAs (snoRNAs) on the maternal chromosome and constitutes

Externí odkaz: https://doaj.org/article/a80c873c04964a5684d8a9616f24fed8

Heterochromatin delays CRISPR-Cas9 mutagenesis but does not influence repair outcome

Autor: Alison M. Meynert, Andrew J. Wood, Martijn J. E. Kelder, Robert Feil, Tracy Ballinger, Keerthi T. Chathoth, Ildem Sanli, Eirini M. Kallimasioti-Pazi, Sébastien Lalevée, Gillian C.A. Taylor

CRISPR-Cas9 genome editing occurs in the context of chromatin, which is heterogeneous in structure and function across the genome. Chromatin heterogeneity is thought to affect genome editing efficiency, but this has been challenging to quantify due t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0ca727ec93106708b2122e5b68936ca

SUG-1 Plays Proteolytic and Non-proteolytic Roles in the Control of Retinoic Acid Target Genes via Its Interaction with SRC-3

Autor: Maurizio Gianni, Enrico Garattini, Jean Luc Plassat, Ivan Raska, Sébastien Lalevée, Cécile Rochette-Egly, Nathalie Bruck, Christine Ferry

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2009, 284 (12), pp.8127-35. ⟨10.1074/jbc.M808815200⟩
Journal of Biological Chemistry, 2009, 284 (12), pp.8127-35. ⟨10.1074/jbc.M808815200⟩

International audience; Nuclear retinoic acid receptor alpha (RARalpha) activates gene expression through dynamic interactions with coregulatory protein complexes, the assembly of which is directed by the ligand and the AF-2 domain of RARalpha. Then

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e12401eb85402a96e584602de61d6fa
https://doi.org/10.1074/jbc.m808815200

Vinexin β Interacts with the Non-phosphorylated AF-1 Domain of Retinoid Receptor γ (RARγ) and Represses RARγ-mediated Transcription

Autor: Sébastien Lalevée, Jean-Luc Plassat, Cécile Rochette-Egly, Annie Bauer, Gaétan Bour

Publikováno v: Journal of Biological Chemistry. 280:17027-17037

Nuclear retinoic acid receptors (RARs) are ligand-dependent transcription factors that regulate the expression of retinoic acid target genes. Although the importance of RAR phosphorylation in their N-terminal domain is clearly established, the underl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ee867e7b9f16bc037ebee71a94faa8a9
https://doi.org/10.1074/jbc.m501344200

Phosphorylation Control of Nuclear Receptors

Autor: Sébastien Lalevée, Cécile Rochette-Egly, Christine Ferry

Publikováno v: Methods in Molecular Biology ISBN: 9781607617372

Most transcription factors including nuclear receptors (NRs) act as sensors of the extracellular and intracellular compartments. As such, NRs serve as integrating platforms for a variety of stimuli and are targets for Post-translational modifications

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c07643117b73ccc871d08afbf7f29d7d
https://doi.org/10.1007/978-1-60761-738-9_15