Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Sébastien Jacquier"'
Autor:
Claudia Betschart, Michael Faller, Florence Zink, René Hemmig, Jutta Blank, Eric Vangrevelinghe, Marjorie Bourrel, Ralf Glatthar, Dirk Behnke, Kerstin Barker, Andreas Heizmann, Daniela Angst, Pierre Nimsgern, Sébastien Jacquier, Tobias Junt, Géraldine Zipfel, Giulia Ruzzante, Pius Loetscher, Sarah Limonta, Stuart Hawtin, Cedric Bernard Andre, Thomas Boulay, Roland Feifel, Thomas Knoepfel
Publikováno v:
ACS Med Chem Lett
[Image: see text] Inappropriate activation of TLR7 and TLR8 is linked to several autoimmune diseases, such as lupus erythematosus. Here we report on the efficient structure-based optimization of the inhibition of TLR8, starting from a co-crystal stru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33fee8bacdcd6ab213f658c3a1348d56
https://doi.org/10.1021/acsmedchemlett.1c00696
https://doi.org/10.1021/acsmedchemlett.1c00696
Publikováno v:
Tetrahedron Letters. 56:2860-2862
The preparation of a series of 3-fluoro-2-substituted-6-nitro benzoic acids is described. The partially excellent regioselectivities observed in the nitration step can be rationalized in most cases using Fukui indices of local nucleophilicity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a78182513d7531601a1cf2bcabfaafc4
https://doi.org/10.1016/j.tetlet.2015.04.057
https://doi.org/10.1016/j.tetlet.2015.04.057
Publikováno v:
ChemInform. 46
The partially excellent regioselectivities of the nitration reaction is rationalized in most cases using Fukui indices of local nucleophilicity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6a10ceb69faf4280e2a987ab9a48720
https://doi.org/10.1002/chin.201536086
https://doi.org/10.1002/chin.201536086