Výsledky vyhledávání - "Sébastien Igonet"

Lactobionamide-based fluorinated detergent for functional and structural stabilization of membrane proteins

Autor: Romain Besson, Clarisse Faugier, Grégory Durand, Damien Cornut, Sébastien Igonet, Anass Jawhari

Publikováno v: Methods
Methods, Elsevier, 2020, 180, pp.19-26. ⟨10.1016/j.ymeth.2020.02.005⟩

Membrane proteins (MPs) are important drug discovery targets for a wide range of diseases. Conventional detergents such as n-Dodecyl β-D-maltoside have been used largely and efficiently to solubilize MPs with varying degrees of success concerning MP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::887d21b4c45e03f5b8612cf131678ff4
https://hal.archives-ouvertes.fr/hal-03493270

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Novel systematic detergent screening method for membrane proteins solubilization

Autor: Elodie Desuzinges Mandon, Anass Jawhari, Rebecca Pellegrin, Morgane Agez, Sébastien Igonet

Publikováno v: Analytical Biochemistry. 517:40-49

Membrane proteins play crucial role in many cellular processes including cell adhesion, cell-cell communication, signal transduction and transport. To better understand the molecular basis of such central biological machines and in order to specifica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4da9cb782ccb272ac4d9cd09a5522a40
https://doi.org/10.1016/j.ab.2016.11.008

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Glycosylated Amphiphilic Calixarene‐Based Detergent for Functional Stabilization of Native Membrane Proteins

Autor: Emmanuel Dejean, Sébastien Igonet, Elodie Mandon Desuzinges, Damien Cornut, Marine Soulié, Emilie Grousson, Anass Jawhari, Clarisse Faugier, Grégory Durand, Julien Dauvergne, Françoise Bonneté

Publikováno v: ChemistrySelect
ChemistrySelect, Wiley, 2019, 4 (19), pp.5535-5539. ⟨10.1002/slct.201901220⟩

International audience; Structure-function and drug discovery studies of membrane proteins (MPs) require their extraction from cell membranes. Here we report the synthesis and use of novel glycosylated amphiphilic calixarene-based detergent, named CA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdb8ef7e1b4b1e8049b9bb133d5d5690
https://hal.archives-ouvertes.fr/hal-02360249

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Hydrogenated diglucose detergents for membrane-protein extraction and stabilization

Autor: Marine Soulié, Carolyn Vargas, Pierre Guillet, Anass Jawhari, Kelly Garnier, Grégory Durand, Gildas Nyame Mendendy Boussambe, Florian Mahler, Sébastien Igonet, Christine Ebel, Sandro Keller

Publikováno v: Langmuir
Langmuir, 2019, 35 (12), pp.4287-4295. ⟨10.1021/acs.langmuir.8b02842⟩
Langmuir, American Chemical Society, 2019, 35 (12), pp.4287-4295. ⟨10.1021/acs.langmuir.8b02842⟩

International audience; We report herein the design and synthesis of a novel series of alkyl glycosides detergents consisting of a nonionic polar headgroup that comprises two glucose moieties in a branched arrangement (DG), onto which octane-, decane

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57de54301217b94fced3c05ba32f8aa1
https://hal.science/hal-02057167

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Enabling STD-NMR fragment screening using stabilized native GPCR: A case study of adenosine receptor

Autor: Anass Jawhari, Maciej Baranowski, Olivier Cala, Javier Pérez, Isabelle Krimm, Erika Cecon, Ralf Jockers, Maja Pučić-Baković, Claire Raingeval, Gordan Lauc, Sébastien Igonet

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Scientific Reports
Scientific Reports, Nature Publishing Group, 2018, 8 (1), pp. Article Number: 8142 ⟨10.1038/s41598-018-26113-0⟩
Scientific Reports, 2018, 8 (1), pp. Article Number: 8142 ⟨10.1038/s41598-018-26113-0⟩

We thank Emmanuel DEJEAN for continuous support, Kelly GARNIER for help with thermal-shift assay and the CALIXAR team for helpful discussions. We would like to thank Patrick SCHULTZ for initial electron microscopy work and discussions and Alice ROTHN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb399d5b559bb1d1510bedf62019aad4
https://doi.org/10.1038/s41598-018-26113-0

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Glycosyl-Substituted Dicarboxylates as Detergents for the Extraction, Overstabilization, and Crystallization of Membrane Proteins

Autor: Sandrine Magnard, Pierre Falson, Saravanan Mounien, Sébastien Igonet, Veronica Zampieri, Romain Haudecoeur, Cédric Boyère, Marine Peuchmaur, Kim-Anh Nguyen, Anass Jawhari, Vincent Chaptal, Ahcène Boumendjel, Ikram Benammar

Publikováno v: Angewandte Chemie International Edition
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2018, 57 (11), pp.2948-2952. ⟨10.1002/anie.201713395⟩

To tackle the problems associated with membrane protein (MP) instability in detergent solutions, we designed a series of glycosyl-substituted dicarboxylate detergents (DCODs) in which we optimized the polar head to clamp the membrane domain by includ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::182233eebcd281cc95b84fe6e463d066
https://hal.archives-ouvertes.fr/hal-02329303

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X-ray structure of the arenavirus glycoprotein GP2 in its postfusion hairpin conformation

Autor: Enrico A. Stura, Gérard Bricogne, Clemens Vonrhein, Sébastien Igonet, Bruno Eschli, Marie-Christine Vaney, Félix A. Rey, Hans Hengartner

Publikováno v: Proceedings of the National Academy of Sciences

Arenaviruses are important agents of zoonotic disease worldwide. The virions expose a tripartite envelope glycoprotein complex at their surface, formed by the glycoprotein subunits GP1, GP2 and the stable signal peptide. This complex is responsible f

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