Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Sébastien GOUTAL"'
Autor:
Clémence Disdier, Amélie Soyer, Léa Broca-Brisson, Sébastien Goutal, Anne-Cécile Guyot, Nora Ziani, Louise Breuil, Alexandra Winkeler, Gaëlle Hugon, Thomas Joudinaud, Henri Bénech, Jean Armengaud, Matthew R. Skelton, Rania Harati, Rifat A. Hamoudi, Nicolas Tournier, Aloïse Mabondzo
Publikováno v:
Neurobiology of Disease, Vol 202, Iss , Pp 106720- (2024)
Creatine transporter deficiency (CTD) is an inborn error of creatine (Cr) metabolism in which Cr is not properly distributed to the brain due to a mutation in the Cr transporter (CrT) SLC6A8 gene. CTD is associated with developmental delays and with
Externí odkaz:
https://doaj.org/article/bde823f812f9471790485c819bd60d17
Autor:
Amélie Soyer, Sarah Leterrier, Louise Breuil, Maud Goislard, Claire Leroy, Wadad Saba, Karine Thibault, Gregory Dal Bo, Michel Bottlaender, Fabien Caillé, Sébastien Goutal, Nicolas Tournier
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
AimBuprenorphine mainly acts as an agonist of mu-opioid receptors (mu-OR). High dose buprenorphine does not cause respiratory depression and can be safely administered to elicit typical opioid effects and explore pharmacodynamics. Acute buprenorphine
Externí odkaz:
https://doaj.org/article/84f391e756a8445887e0ec19d709974d
Autor:
Sébastien Goutal, Martine Guillermier, Guillaume Becker, Mylène Gaudin, Yann Bramoullé, André Luxen, Christian Lemaire, Alain Plenevaux, Eric Salmon, Philippe Hantraye, Olivier Barret, Nadja Van Camp
Publikováno v:
EJNMMI Research, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Background Positron Emission Tomography (PET) imaging of the Synaptic Vesicle glycoprotein (SV) 2A is a new tool to quantify synaptic density. [18F]UCB-H was one of the first promising SV2A-ligands to be labelled and used in vivo in rodent a
Externí odkaz:
https://doaj.org/article/6d181ae0a04a4f74826c698f97fe1723
Autor:
Gaëlle Hugon, Sébastien Goutal, Marie Sarazin, Michel Bottlaender, Fabien Caillé, Marine Droguerre, Mathieu Charvériat, Alexandra Winkeler, Nicolas Tournier
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Translational methods are needed to monitor the impact of the Alzheimer’s disease (AD) and therapies on brain function in animal models and patients. The formation of amyloid plaques was investigated using [18F]florbetapir autoradiography in a mous
Externí odkaz:
https://doaj.org/article/b966a39789d14350a6209274cc70f3de
Autor:
Malvika Sardana, Louise Breuil, Sébastien Goutal, Maud Goislard, Mikhail Kondrashov, Etienne Marchal, Florent L. Besson, Christophe Dugave, Gail Wrigley, Anna C. Jonson, Bertrand Kuhnast, Magnus Schou, Nicolas Tournier, Charles S. Elmore, Fabien Caillé
Publikováno v:
Pharmaceuticals, Vol 15, Iss 12, p 1568 (2022)
Crizotinib is a tyrosine kinase inhibitor approved for the treatment of non-small-cell lung cancer, but it is inefficient on brain metastases. Crizotinib is a substrate of the P-glycoprotein, and non-invasive nuclear imaging can be used to assess the
Externí odkaz:
https://doaj.org/article/656bb5c2d5524b698cef9f5f5f03ef39
Autor:
Louise Breuil, Nora Ziani, Sarah Leterrier, Gaëlle Hugon, Fabien Caillé, Viviane Bouilleret, Charles Truillet, Maud Goislard, Myriam El Biali, Martin Bauer, Oliver Langer, Sébastien Goutal, Nicolas Tournier
Publikováno v:
Pharmaceutics, Vol 14, Iss 12, p 2650 (2022)
[11C]metoclopramide PET imaging provides a sensitive and translational tool to explore P-glycoprotein (P-gp) function at the blood-brain barrier (BBB). Patients with neurological diseases are often treated with cytochrome (CYP) modulators which may i
Externí odkaz:
https://doaj.org/article/e65cab58e713472f90382c0f7d93f2af
Autor:
Louise Breuil, Sébastien Goutal, Solène Marie, Antonio Del Vecchio, Davide Audisio, Amélie Soyer, Maud Goislard, Wadad Saba, Nicolas Tournier, Fabien Caillé
Publikováno v:
Pharmaceutics, Vol 14, Iss 8, p 1658 (2022)
Domperidone and metoclopramide are widely prescribed antiemetic drugs with distinct neurological side effects. The impact of P-glycoprotein (P-gp)-mediated efflux at the blood–brain barrier (BBB) on brain exposure and BBB permeation was compared in
Externí odkaz:
https://doaj.org/article/4e969819b45f42e6b09eeef63d0adaeb
Autor:
Marion Tisseraud, Sébastien Goutal, Thomas Bonasera, Maud Goislard, Delphine Desjardins, Roger Le Grand, Chris M. Parry, Nicolas Tournier, Bertrand Kuhnast, Fabien Caillé
Publikováno v:
Pharmaceuticals, Vol 15, Iss 5, p 587 (2022)
Deciphering the drug/virus/host interactions at infected cell reservoirs is a key leading to HIV-1 remission for which positron emission tomography (PET) imaging using radiolabeled antiretroviral (ARV) drugs is a powerful asset. Dolutegravir (DTG) is
Externí odkaz:
https://doaj.org/article/b4e19d492b3942dba23bb99b94b57b48
Autor:
Sébastien Goutal, Nicolas Tournier, Martine Guillermier, Nadja Van Camp, Olivier Barret, Mylène Gaudin, Michel Bottlaender, Philippe Hantraye, Sonia Lavisse
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0240228 (2020)
IntroductionKnowledge of the repeatability of quantitative parameters derived from [18F]FDG PET images is essential to define the group size and allow correct interpretation. Here we tested repeatability and accuracy of different [18F]FDG absolute an
Externí odkaz:
https://doaj.org/article/51bb3114c4074d75b8a6f16febedf038
Autor:
Solène Marie, Irene Hernández-Lozano, Marc Le Vée, Louise Breuil, Wadad Saba, Maud Goislard, Sébastien Goutal, Charles Truillet, Oliver Langer, Olivier Fardel, Nicolas Tournier
Publikováno v:
Pharmaceuticals, Vol 15, Iss 4, p 392 (2022)
Endotoxemia-induced inflammation may impact the activity of hepatocyte transporters, which control the hepatobiliary elimination of drugs and bile acids. 99mTc-mebrofenin is a non-metabolized substrate of transporters expressed at the different poles
Externí odkaz:
https://doaj.org/article/27ee7558c859412bb9672fe2db8e091a