Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Sébastien G. Gouin"'
Autor:
Mathieu Mével, Virginie Pichard, Mohammed Bouzelha, Dimitri Alvarez-Dorta, Pierre-Alban Lalys, Nathalie Provost, Marine Allais, Alexandra Mendes, Elodie Landagaray, Jean-Baptiste Ducloyer, Estelle Toublanc, Anne Galy, Nicole Brument, Gaëlle M. Lefevre, Sébastien G. Gouin, Carolina Isiegas, Guylène Le Meur, Thérèse Cronin, Caroline Le Guiner, Michel Weber, Philippe Moullier, Eduard Ayuso, David Deniaud, Oumeya Adjali
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 1, Pp 101187- (2024)
Inherited retinal diseases are a leading and untreatable cause of blindness and are therefore candidate diseases for gene therapy. Recombinant vectors derived from adeno-associated virus (rAAV) are currently the most promising vehicles for in vivo th
Externí odkaz:
https://doaj.org/article/1edecadd12924319b147b4cab1a426f8
Autor:
Aurélien Leray, Pierre-Alban Lalys, Juliette Varin, Mohammed Bouzelha, Audrey Bourdon, Dimitri Alvarez-Dorta, Karine Pavageau, Sébastien Depienne, Maia Marchand, Anthony Mellet, Joanna Demilly, Jean-Baptiste Ducloyer, Tiphaine Girard, Bodvaël Fraysse, Mireille Ledevin, Mickaël Guilbaud, Sébastien G. Gouin, Eduard Ayuso, Oumeya Adjali, Thibaut Larcher, Thérèse Cronin, Caroline Le Guiner, David Deniaud, Mathieu Mével
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 171, Iss , Pp 116148- (2024)
Decades of biological and clinical research have led to important advances in recombinant adeno-associated viruses rAAV-based gene therapy gene therapy. However, several challenges must be overcome to fully exploit the potential of rAAV vectors. Inno
Externí odkaz:
https://doaj.org/article/1ed978775aad41fbbbc3787da57c93b5
Autor:
Sébastien Depienne, Mohammed Bouzelha, Emmanuelle Courtois, Karine Pavageau, Pierre-Alban Lalys, Maia Marchand, Dimitri Alvarez-Dorta, Steven Nedellec, Laura Marín-Fernández, Cyrille Grandjean, Mohammed Boujtita, David Deniaud, Mathieu Mével, Sébastien G. Gouin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Methods for direct covalent ligation of microorganism surfaces remain poorly reported, and mostly based on metabolic engineering for bacteria and cells functionalization. While effective, a faster method avoiding the bio-incorporation step w
Externí odkaz:
https://doaj.org/article/9a8372bffce447fba60a510ec2630d83
Autor:
Hyungjun Yang, Hengameh Chloé Mirsepasi-Lauridsen, Carsten Struve, Joannie M. Allaire, Adeline Sivignon, Wayne Vogl, Else S. Bosman, Caixia Ma, Abbas Fotovati, Gregor S. Reid, Xiaoxia Li, Andreas Munk Petersen, Sébastien G. Gouin, Nicolas Barnich, Kevan Jacobson, Hong Bing Yu, Karen Angeliki Krogfelt, Bruce A. Vallance
Publikováno v:
Gut Microbes, Vol 12, Iss 1 (2020)
Ulcerative colitis (UC) is a chronic inflammatory condition linked to intestinal microbial dysbiosis, including the expansion of E. coli strains related to extra-intestinal pathogenic E. coli. These “pathobionts” exhibit pathogenic properties, bu
Externí odkaz:
https://doaj.org/article/07f63ac643414f119424c94c5a08b3e7
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
Availability of purified drug target is a prerequisite for its structural and functional characterization. However, aggregation of recombinant protein as inclusion bodies (IBs) is a common problem during the large scale production of overexpressed pr
Externí odkaz:
https://doaj.org/article/483f8cad6ea147bca08b1424e0f5da47
Autor:
Tetiana Dumych, Nao Yamakawa, Adeline Sivignon, Estelle Garenaux, Stefania Robakiewicz, Bernadette Coddeville, Antonino Bongiovanni, Fabrice Bray, Nicolas Barnich, Sabine Szunerits, Christian Slomianny, Martin Herrmann, Sébastien G. Gouin, Alexander D. Lutsyk, Luis E. Munoz, Frank Lafont, Christian Rolando, Rostyslav Bilyy, Julie M. J. Bouckaert
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
A novel mechanism is revealed by which clinical isolates of adherent-invasive Escherichia coli (AIEC) penetrate into the epithelial cell layer, replicate, and establish biofilms in Crohn's disease. AIEC uses the FimH fimbrial adhesin to bind to oligo
Externí odkaz:
https://doaj.org/article/3d043b28b2414895a5dff9140868b553
Autor:
Tetiana Dumych, Clarisse Bridot, Sébastien G. Gouin, Marc F. Lensink, Solomiya Paryzhak, Sabine Szunerits, Ralf Blossey, Rostyslav Bilyy, Julie Bouckaert, Eva-Maria Krammer
Publikováno v:
Molecules, Vol 23, Iss 11, p 2794 (2018)
The fimbrial lectin FimH from uro- and enteropathogenic Escherichia coli binds with nanomolar affinity to oligomannose glycans exposing Manα1,3Man dimannosides at their non-reducing end, but only with micromolar affinities to Manα1,2Man dimannoside
Externí odkaz:
https://doaj.org/article/a9351840b7344cf49cc13357fb8bcf0b
Autor:
Adeline Sivignon, Xibo Yan, Dimitri Alvarez Dorta, Richard Bonnet, Julie Bouckaert, Etienne Fleury, Julien Bernard, Sébastien G. Gouin, Arlette Darfeuille-Michaud, Nicolas Barnich
Publikováno v:
mBio, Vol 6, Iss 6 (2015)
ABSTRACT The ileal lesions of Crohn's disease (CD) patients are colonized by adherent-invasive Escherichia coli (AIEC) bacteria. These bacteria adhere to mannose residues expressed by CEACAM6 on host cells in a type 1 pilus-dependent manner. In this
Externí odkaz:
https://doaj.org/article/1ef07e44bddd4567876566ae20c1d360
Autor:
Mathieu Mével, Virginie Pichard, Mohammed Bouzelha, Dimitri Alvarez-Dorta, Pierre-Alban Lalys, Nathalie Provost, Marine Allais, Alexandra Mendes, Elodie Landagaray, Jean-Baptiste Ducloyer, Anne Galy, Nicole Brument, Gaëlle M. Lefevre, Sébastien G. Gouin, Carolina Isiegas, Guylène Le Meur, Thérèse Cronin, Caroline Le Guiner, Michel Weber, Philippe Moullier, Eduard Ayuso, David Deniaud, Oumeya Adjali
Inherited retinal diseases are a leading and untreatable cause of blindness and are therefore candidate diseases for gene therapy. Recombinant vectors derived from adeno-associated virus (rAAV) are currently the most promising vehicles forin vivother
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::754177853388fd915b92c4ee4b3e16c7
https://doi.org/10.1101/2022.12.01.518481
https://doi.org/10.1101/2022.12.01.518481
Publikováno v:
ChemistrySelect
ChemistrySelect, Wiley, 2019, 4 (42), pp.12232-12235. ⟨10.1002/slct.201903391⟩
ChemistrySelect, Wiley, 2019, 4 (42), pp.12232-12235. ⟨10.1002/slct.201903391⟩
International audience; Unusual purine nucleoside analogues were synthesized, using the well-tried methodology in heterocyclic chemistry. This result expands the scope of accessible N-glycosylated heterocyclic structures. Pyrimidine, and bicyclic pyr