Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Sébastien Conus"'
Publikováno v:
Trends in Immunology
Neutrophils, eosinophils, and basophils play essential roles during microbe-induced and sterile inflammation. The severity of such inflammatory processes is controlled, at least in part, by factors that regulate cell death and survival of granulocyte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90a81be4043c0191397fe3cbd4e7c912
https://doi.org/10.1016/j.it.2013.04.002
https://doi.org/10.1016/j.it.2013.04.002
Autor:
Cristina C. Mihalache, Peter M. Villiger, Shida Yousefi, E. Marion Schneider, Sébastien Conus, Hans-Uwe Simon
Publikováno v:
Journal of immunology (Baltimore Md. : 1950)
The most common form of neutrophil death, under both physiological and inflammatory conditions, is apoptosis. In this study, we report a novel form of programmed necrotic cell death, associated with cytoplasmic organelle fusion events, that occurs in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2d87f249385db1e0e12954fad667c7e
Autor:
Sébastien Conus, Hans-Uwe Simon, Nirmala Gonsalves, Christian Bussmann, A. Straumann, Ikuo Hirano, Alain M. Schoepfer
Publikováno v:
The American journal of gastroenterology
OBJECTIVES Esophageal dilation often leads to long lasting relief of dysphagia in eosinophilic esophagitis (EoE). The aim of this study was to define the effectiveness safety and patient acceptance of esophageal dilation in EoE. In addition we examin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::387a4ea0f9caf66803a8843b39957bc3
Autor:
Hirohito Kita, Sébastien Conus, Margaret Byrne, Jatin Patel, Alex Straumann, Pascale Grzonka, Gail M. Kephart, Hans-Uwe Simon, Deborah A. Smith, Christian Bussmann, Christoph Beglinger
Publikováno v:
Gut
OBJECTIVE Eosinophilic oesophagitis (EoO) is a clinicopathological condition defined by proton pump inhibitor refractory oesophageal symptoms combined with oesophageal eosinophilia. The pharmacodynamic effect of mepolizumab (a humanised anti interleu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::967e74a76a4a093adf9da236edb79eaa
https://doi.org/10.1136/gut.2009.178558
https://doi.org/10.1136/gut.2009.178558
Publikováno v:
Cell death and differentiation
Under inflammatory conditions, neutrophil apoptosis is delayed due to survival-factor exposure, a mechanism that prevents the resolution of inflammation. One important proinflammatory cytokine involved in the regulation of neutrophil survival/activat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd24e4d561f053b1c501047a20da06fb
https://doi.org/10.1038/cdd.2009.50
https://doi.org/10.1038/cdd.2009.50
Autor:
Sébastien Conus, Daniela Kassahn, Pascal Schneider, Hans-Uwe Simon, Thomas Brunner, Ueli Nachbur, Olivier Micheau
Publikováno v:
Cell death and differentiation
Fas (CD95/Apo-1) ligand is a potent inducer of apoptosis and one of the major killing effector mechanisms of cytotoxic T cells. Thus, Fas ligand activity has to be tightly regulated, involving various transcriptional and post-transcriptional processe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbeacc21130b28704f18af70816f5936
Autor:
Sébastien Conus, Hans-Uwe Simon
Publikováno v:
Best Practice & Research Clinical Gastroenterology. 22:441-453
Eosinophils and gastrointestinal tract interact in an intimate and enigmatic relationship. Under inflammatory conditions, eosinophil infiltration in the gastrointestinal tract is a common feature of numerous eosinophilic gastrointestinal disorders (E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5d9c464a2efaa956c3f6ff86ce80326
https://doi.org/10.1016/j.bpg.2007.09.003
https://doi.org/10.1016/j.bpg.2007.09.003
Publikováno v:
European Journal of Immunology. 36:1975-1984
The exact molecular mechanisms leading to delayed apoptosis, a phenomenon frequently observed in eosinophil inflammatory responses, remain largely unknown. Here, we show that cultured eosinophils purified from blood of hypereosinophilic syndrome (HES
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cb743ad5d070b5d18e763ff06f56b0a
https://doi.org/10.1002/eji.200635943
https://doi.org/10.1002/eji.200635943
Publikováno v:
The Journal of Immunology. 174:8090-8096
Leptin regulates food intake as well as metabolic, endocrine, and immune functions. It exerts proliferative and antiapoptotic activities in a variety of cell types, including T cells. Leptin also stimulates macrophages and neutrophils, and its produc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c20439148e5e22b9367a42b39c9336f
https://doi.org/10.4049/jimmunol.174.12.8090
https://doi.org/10.4049/jimmunol.174.12.8090
Publikováno v:
Journal of Biological Chemistry. 279:5947-5957
In the absence and in the resolution of inflammatory responses, neutrophils rapidly undergo spontaneous apoptosis. Here we report about a new apoptosis pathway in these cells that requires calpain-1 activation and is essential for the enzymatic activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3b8b0509a7d05a5fbd1deca67dfe195
https://doi.org/10.1074/jbc.m308576200
https://doi.org/10.1074/jbc.m308576200