Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Sébastien Alphonse"'
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Bacterial tyrosine kinases (BY-kinases) comprise a family of protein tyrosine kinases that are structurally distinct from their functional counterparts in eukaryotes and are highly conserved across the bacterial kingdom. BY-kinases act in concert wit
Autor:
Alexandra S. Weinheimer, YiTing Paung, Julie Rageul, Arafat Khan, Brian Ho, Michael Tong, Sébastien Alphonse, Markus A. Seeliger, Hyungjin Kim
Elevated DNA replication stress causes instability of the DNA replication fork and DNA mutations, which underlies tumorigenesis. The DNA replication stress regulator SDE2 binds to TIMELESS (TIM) of the fork protection complex (FPC) and enhances its s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb8b6fafea03ea3779c79e25ca081a6c
https://doi.org/10.1101/2022.05.09.490802
https://doi.org/10.1101/2022.05.09.490802
Autor:
Alexandra S. Weinheimer, YiTing Paung, Julie Rageul, Arafat Khan, Natalie Lo, Brian Ho, Michael Tong, Sébastien Alphonse, Markus A. Seeliger, Hyungjin Kim
Publikováno v:
The Journal of biological chemistry. 298(8)
Elevated DNA replication stress causes instability of the DNA replication fork and increased DNA mutations, which underlies tumorigenesis. The DNA replication stress regulator silencing-defective 2 (SDE2) is known to bind to TIMELESS (TIM), a protein
Publikováno v:
Journal of Biological Chemistry. 299:102737
BY-kinases (for bacterial tyrosine kinases) constitute a family of protein tyrosine kinases that are highly conserved in the bacterial kingdom and occur most commonly as essential components of multicomponent assemblies responsible for the biosynthes
Publikováno v:
Nucleic Acids Research
Tpt1, an essential component of the fungal and plant tRNA splicing machinery, catalyzes transfer of an internal RNA 2′-PO4 to NAD+ yielding RNA 2′-OH and ADP-ribose-1′,2′-cyclic phosphate products. Here, we report NMR structures of the Tpt1 o
Autor:
Rome Vouhoux, Geneviève Ball, Sébastien Alphonse, Cristian A. Escobar, Loïc Quinton, Brice Barbat, Katrina T. Forest, Badreddine Douzi
The type IV filament superfamily comprises widespread membrane-associated polymers in prokaryotes. The Type II secretion system (T2SS), a significant virulence pathway in many pathogens, belongs to this superfamily. A knowledge gap in the understandi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ec5f6b214d9cc3a45800bc942bdb48a
https://doi.org/10.1101/2020.12.11.420943
https://doi.org/10.1101/2020.12.11.420943
Autor:
Ranajeet Ghose, Sébastien Alphonse
Publikováno v:
Methods. 148:100-114
Measurement of nuclear spin relaxation provides a powerful approach to access information about biomolecular conformational dynamics over several orders of magnitude in timescale. In several cases this knowledge in combination with spatial informatio
Publikováno v:
Biochemistry. 57:1568-1571
While solid-state nuclear magnetic resonance (ssNMR) has emerged as a powerful technique for studying viral capsids, current studies are limited to capsids formed from single proteins or single polyproteins. The ability to selectively label individua
Autor:
Ranajeet Ghose, Sébastien Alphonse
P2, an RNA-directed RNA polymerase (RdRP), is encoded on the largest of the three segments of the double-stranded RNA genome of cystoviruses. P2 performs the dual tasks of replication and transcription de novo on single-stranded RNA templates, and pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::516134b7231cddad59075c55a96a154c
https://europepmc.org/articles/PMC5476504/
https://europepmc.org/articles/PMC5476504/
Autor:
Sébastien Alphonse, Ranajeet Ghose, David H. Giles, Kwangwoon Lee, Clint D.J. Tavares, Rebecca M. Wellmann, Andrea Piserchio, Kevin N. Dalby
Publikováno v:
Structure (London, England : 1993). 24(9)
Binding of Ca(2+)-loaded calmodulin (CaM) activates eukaryotic elongation factor 2 kinase (eEF-2K) that phosphorylates eEF-2, its only known cellular target, leading to a decrease in global protein synthesis. Here, using an eEF-2K-derived peptide (eE