Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Sébastien, Moniot"'
Autor:
Rita Machado de Oliveira, Hugo Vicente Miranda, Laetitia Francelle, Raquel Pinho, Éva M Szegö, Renato Martinho, Francesca Munari, Diana F Lázaro, Sébastien Moniot, Patrícia Guerreiro, Luis Fonseca-Ornelas, Zrinka Marijanovic, Pedro Antas, Ellen Gerhardt, Francisco Javier Enguita, Bruno Fauvet, Deborah Penque, Teresa Faria Pais, Qiang Tong, Stefan Becker, Sebastian Kügler, Hilal Ahmed Lashuel, Clemens Steegborn, Markus Zweckstetter, Tiago Fleming Outeiro
Publikováno v:
PLoS Biology, Vol 15, Iss 4, p e1002601 (2017)
[This corrects the article DOI: 10.1371/journal.pbio.2000374.].
Externí odkaz:
https://doaj.org/article/fb415e7f10954b03bf291185f961cdfc
Autor:
Rita Machado de Oliveira, Hugo Vicente Miranda, Laetitia Francelle, Raquel Pinho, Éva M Szegö, Renato Martinho, Francesca Munari, Diana F Lázaro, Sébastien Moniot, Patrícia Guerreiro, Luis Fonseca-Ornelas, Zrinka Marijanovic, Pedro Antas, Ellen Gerhardt, Francisco Javier Enguita, Bruno Fauvet, Deborah Penque, Teresa Faria Pais, Qiang Tong, Stefan Becker, Sebastian Kügler, Hilal Ahmed Lashuel, Clemens Steegborn, Markus Zweckstetter, Tiago Fleming Outeiro
Publikováno v:
PLoS Biology, Vol 15, Iss 3, p e2000374 (2017)
Sirtuin genes have been associated with aging and are known to affect multiple cellular pathways. Sirtuin 2 was previously shown to modulate proteotoxicity associated with age-associated neurodegenerative disorders such as Alzheimer and Parkinson dis
Externí odkaz:
https://doaj.org/article/989eaa37ca2a44718ed354a73c818f4e
Autor:
Xiqun Chen, Pauline Wales, Luisa Quinti, Fuxing Zuo, Sébastien Moniot, Fanny Herisson, Nazifa Abdul Rauf, Hua Wang, Richard B Silverman, Cenk Ayata, Michelle M Maxwell, Clemens Steegborn, Michael A Schwarzschild, Tiago F Outeiro, Aleksey G Kazantsev
Publikováno v:
PLoS ONE, Vol 10, Iss 1, p e0116919 (2015)
Sirtuin deacetylases regulate diverse cellular pathways and influence disease processes. Our previous studies identified the brain-enriched sirtuin-2 (SIRT2) deacetylase as a potential drug target to counteract neurodegeneration. In the present study
Externí odkaz:
https://doaj.org/article/6d4507c8725e4994b616076e9bb86115
Publikováno v:
Journal of structural biology. 211(2)
In many organisms, the ubiquitous second messenger cAMP is formed by at least one member of the adenylyl cyclase (AC) Class III. These ACs feature a conserved dimeric catalytic core architecture, either through homodimerization or through pseudo-hete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1994c98bf2dc81b4d22b8e7afcf6c85e
https://pubmed.ncbi.nlm.nih.gov/32454240
https://pubmed.ncbi.nlm.nih.gov/32454240
Autor:
Clemens Steegborn, Roberta Foresti, Sébastien Moniot, Lucia Tamborini, C. De Micheli, Andrea Pinto, Z. El Ali
Publikováno v:
ChemistryOpen
Natural and synthetic electrophilic compounds have been shown to activate the antioxidant protective Nrf2 (nuclear factor erythroid 2‐related factor 2)/heme oxygenase‐1 (HO‐1) axis in cells and tissues. Here, we tested the ability of different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62d7ecc2d7f63cbb770b46cc0be093a5
https://doi.org/10.1002/open.201800185
https://doi.org/10.1002/open.201800185
Autor:
Alvin J. Y. Ling, Clemens Steegborn, Vera Gorbunova, Jun Li, Dapeng Zhang, Bo Qin, Michael Bonkowski, David A. Sinclair, Basil P. Hubbard, Sébastien Moniot, Zhenkun Lou, L. Aravind, Luis A. Rajman
Publikováno v:
Science. 355:1312-1317
DNA repair is essential for life, yet its efficiency declines with age for reasons that are unclear. Numerous proteins possess Nudix homology domains (NHDs) that have no known function. We show that NHDs are NAD+ (oxidized form of nicotinamide adenin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa0ff8bba773533c07c5bd4b73d1ca00
https://doi.org/10.1126/science.aad8242
https://doi.org/10.1126/science.aad8242
Autor:
Laura Lledo Bryant, Marc Juraschitz, Stefanie Schrottke, Andreas Möglich, Günter Mayer, Thea Ziegler, Ankana Kakoti, Lisa Sixt, Christian Renzl, Georg Pietruschka, Sebastian Pilsl, Robert Bittl, Clemens Steegborn, Sébastien Moniot, Jennifer Kaiser, Anna Weber
Publikováno v:
Nature chemical biology
Sensory photoreceptor proteins underpin light-dependent adaptations in nature and enable the optogenetic control of organismal behavior and physiology. We identified the bacterial light-oxygen-voltage (LOV) photoreceptor PAL that sequence-specificall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b0957faff9cc411f32941a6ec2abfae
Autor:
Maria Angulo-Ibanez, Johan Auwerx, Katrin F. Chua, William Giblin, David Gius, Leonard Guarente, Angela H. Guo, Marcia C. Haigis, Sylvana Hassanieh, Kathleen A. Hershberger, Matthew D. Hirschey, Shin-ichiro Imai, Alice E. Kane, Elena Katsyuba, Aleksey G. Kazantsev, Hening Lin, David B. Lombard, Sébastien Moniot, Raul Mostoslavsky, Tiago F. Outeiro, David A. Sinclair, Clemens Steegborn, Adam B. Stein, Éva M. Szegő, Robert A.H. van de Ven, Athanassios Vassilopoulos, Rui-Hong Wang, Wen Yang, Mitsukuni Yoshida, Weijie You
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43cec83b0e139b92c8d36f2a223b81f4
https://doi.org/10.1016/b978-0-12-813499-3.00018-6
https://doi.org/10.1016/b978-0-12-813499-3.00018-6
Sirtuins are evolutionary conserved, NAD + -dependent protein lysine deacylases regulating functions such as energy metabolism and stress responses. They have been implicated in aging processes and the seven human isoforms, Sirt1–7, are considered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2b56904d3f20e232be8f8f3cf05d46d
https://doi.org/10.1016/b978-0-12-813499-3.00005-8
https://doi.org/10.1016/b978-0-12-813499-3.00005-8
Autor:
Colúm Connolly, Clemens Steegborn, Donald C. Lo, Albena T. Dinkova-Kostova, Andrew Snyder, Vanita Chopra, Alexei Degterev, Michael A. Schwarzschild, Cho Low, Ulrike Träger, Leslie M. Thompson, Michael J. Van Kanegan, James R. Miller, Matthew Fuszard, Ningzhe Zhang, Ellen Sapp, Susanta Samajdar, Lisa Meisel, Kimberly B. Kegel-Gleason, Petr Vodicka, Adelaide Tousley, Lisa M. Ellerby, David Llères, Sébastien Moniot, Aleksey G. Kazantsev, Steven M. Hersch, Lisa A. Crawford, Ross S. Stein, Sarah J. Tabrizi, Eranthie Weerapana, Vijay Potluri, Linda S. Kaltenbach, Ruth Farmer, Blair R. Leavitt, Maureen Higgins, Luisa Quinti, Marian DiFiglia, Sharadha Dayalan Naidu, Xiqun Chen
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 114, iss 23
The activity of the transcription factor nuclear factor-erythroid 2 p45-derived factor 2 (NRF2) is orchestrated and amplified through enhanced transcription of antioxidant and antiinflammatory target genes. The present study has characterized a triaz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bba6be10075b3b40875d35cd1e72bd7
https://researchonline.lshtm.ac.uk/id/eprint/3931063/1/KEAP1.pdf
https://researchonline.lshtm.ac.uk/id/eprint/3931063/1/KEAP1.pdf