Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Sébastien, Huet"'
Autor:
Jenny Kaur Singh, Rebecca Smith, Magdalena B. Rother, Anton J. L. de Groot, Wouter W. Wiegant, Kees Vreeken, Ostiane D’Augustin, Robbert Q. Kim, Haibin Qian, Przemek M. Krawczyk, Román González-Prieto, Alfred C. O. Vertegaal, Meindert Lamers, Sébastien Huet, Haico van Attikum
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
Classical non-homologous end-joining (cNHEJ) is the dominant pathway used by human cells to repair DNA double-strand breaks (DSBs) and maintain genome stability. Here the authors show that PARP1-driven chromatin expansion allows the recruitment of ZN
Externí odkaz:
https://doaj.org/article/81eb6422ad4941fe875820f223a85fd7
Autor:
Evgeniia Prokhorova, Florian Zobel, Rebecca Smith, Siham Zentout, Ian Gibbs-Seymour, Kira Schützenhofer, Alessandra Peters, Joséphine Groslambert, Valentina Zorzini, Thomas Agnew, John Brognard, Michael L. Nielsen, Dragana Ahel, Sébastien Huet, Marcin J. Suskiewicz, Ivan Ahel
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
PARP inhibitors function by trapping PARP1 protein on DNA breaks, which has cytotoxic consequences to cancer cells. Here the authors identify three serine residues within PARP1 as key sites whose efficient HPF1-dependent modification counters PARP1 t
Externí odkaz:
https://doaj.org/article/a461bc488c0d420bbd8c111fb3a6c0b4
Autor:
Magdalena B. Rother, Stefania Pellegrino, Rebecca Smith, Marco Gatti, Cornelia Meisenberg, Wouter W. Wiegant, Martijn S. Luijsterburg, Ralph Imhof, Jessica A. Downs, Alfred C. O. Vertegaal, Sébastien Huet, Matthias Altmeyer, Haico van Attikum
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
Chromatin is dynamically remodeled in response to DNA damage in favour of repair. Here the authors reveal how the chromatin remodeler CHD7 and chromatin binding protein 53BP1 regulate distinct DNA repair pathways.
Externí odkaz:
https://doaj.org/article/297076b4803a47eba7a1ecb7f931f8c7
Autor:
Claude Emmanuel Koutouan, Valérie Le Clerc, Anita Suel, Latifa Hamama, Patricia Claudel, David Halter, Raymonde Baltenweck, Philippe Hugueney, Jean-François Chich, Sitti Anlati Moussa, Clémentine Champlain, Sébastien Huet, Linda Voisine, Sandra Pelletier, Sandrine Balzergue, Wilfried Chevalier, Emmanuel Geoffriau, Mathilde Briard
Publikováno v:
Metabolites, Vol 13, Iss 1, p 71 (2023)
Alternaria leaf blight, caused by the fungus Alternaria dauci, is the most damaging foliar disease of carrot. Some carrot genotypes exhibit partial resistance to this pathogen and resistance Quantitative Trait Loci (rQTL) have been identified. Co-loc
Externí odkaz:
https://doaj.org/article/0669b386a1564441bec0e8a687fb38f5
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
DNA repair requires a coordinated effort from an array of factors that play different roles in the DNA damage response from recognizing and signaling the presence of a break, creating a repair competent environment, and physically repairing the lesio
Externí odkaz:
https://doaj.org/article/3ae1a349cef14eb090dbecb3b8d142b7
Autor:
Benoit Dehapiot, Raphaël Clément, Anne Bourdais, Virginie Carrière, Sébastien Huet, Guillaume Halet
Publikováno v:
PLoS Biology, Vol 19, Iss 9, p e3001376 (2021)
Mammalian oocyte meiotic divisions are highly asymmetric and produce a large haploid gamete and 2 small polar bodies. This relies on the ability of the cell to break symmetry and position its spindle close to the cortex before anaphase occurs. In met
Externí odkaz:
https://doaj.org/article/f47342eb8aac4d47b454515302406523
Autor:
Rebecca Smith, Siham Zentout, Magdalena Rother, Nicolas Bigot, Catherine Chapuis, Alexandra Mihuț, Florian Franz Zobel, Ivan Ahel, Haico van Attikum, Gyula Timinszky, Sébastien Huet
Publikováno v:
Nature Structural and Molecular Biology
Nature Structural and Molecular Biology, 2023, ⟨10.1038/s41594-023-00977-x⟩
Nature Structural and Molecular Biology, 2023, ⟨10.1038/s41594-023-00977-x⟩
International audience; Poly(ADP-ribose) polymerase 1 (PARP1) activity is regulated by its co-factor histone poly(ADP-ribosylation) factor 1 (HPF1). The complex formed by HPF1 and PARP1 catalyzes ADP-ribosylation of serine residues of proteins near D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edc378b510b7272ffed1cfa264e6011f
https://doi.org/10.1038/s41594-023-00977-x
https://doi.org/10.1038/s41594-023-00977-x
Autor:
Wilfried Chevalier, Sitti-Anlati Moussa, Miguel Medeiros Netto Ottoni, Cécile Dubois-Laurent, Sébastien Huet, Christophe Aubert, Elsa Desnoues, Brigitte Navez, Valentine Cottet, Guillaume Chalot, Michel Jost, Laure Barrot, Gerald Freymark, Maarten Uittenbogaard, François Chaniet, Anita Suel, Marie-Hélène Bouvier Merlet, Latifa Hamama, Valérie Le Clerc, Mathilde Briard, Didier Peltier, Emmanuel Geoffriau
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0249613 (2021)
Renewed consumer demand motivates the nutritional and sensory quality improvement of fruits and vegetables. Specialized metabolites being largely involved in nutritional and sensory quality of carrot, a better knowledge of their phenotypic variabilit
Externí odkaz:
https://doaj.org/article/b1fa6c0fd9f041d98c65967fbc942a58
Publikováno v:
AIMS Biophysics, Vol 5, Iss 3, Pp 182-193 (2018)
Chromatin is a complex multi-scale structure composed of DNA wrapped around nucleosomes. The compaction state is finely regulated mainly by epigenetic marks present not only on nucleosomes but also on the DNA itself. The most studied DNA post-transcr
Externí odkaz:
https://doaj.org/article/362a6f85a7544b7bb228eb3bfd4a2a54
Autor:
Edoardo José Longarini, Helen Dauben, Carolina Locatelli, Anne R. Wondisford, Rebecca Smith, Charlotte Muench, Andreas Kolvenbach, Michelle Lee Lynskey, Alexis Pope, Juan José Bonfiglio, Eva Pinto Jurado, Roberta Fajka-Boja, Thomas Colby, Marion Schuller, Ivan Ahel, Gyula Timinszky, Roderick J. O’Sullivan, Sébastien Huet, Ivan Matic
Publikováno v:
Molecular Cell
Molecular Cell, 2023, 83 (10), pp.1743-1760.e11. ⟨10.1016/j.molcel.2023.03.027⟩
Molecular Cell, 2023, 83 (10), pp.1743-1760.e11. ⟨10.1016/j.molcel.2023.03.027⟩
International audience; PARP1, an established anti-cancer target that regulates many cellular pathways, including DNA repair signaling, has been intensely studied for decades as a poly(ADP-ribosyl)transferase. Although recent studies have revealed th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1601d4dc993fd64a43906626e289a5e
https://hal.science/hal-04121387/file/hal-04121387.pdf
https://hal.science/hal-04121387/file/hal-04121387.pdf
