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Sex and Estrous Cycle Are Not Mediators of S-Ketamine's Rapid-Antidepressant Behavioral Effects in a Genetic Rat Model of Depression

Autor: Shokouh Arjmand, Marie Vadstrup Pedersen, Nicole R Silva, Anne M Landau, Sâmia Joca, Gregers Wegener

Publikováno v: Arjmand, S, Vadstrup Pedersen, M, Silva, N R, Landau, A M, Joca, S & Wegener, G 2023, ' Sex and Estrous Cycle Are Not Mediators of S-Ketamine's Rapid-Antidepressant Behavioral Effects in a Genetic Rat Model of Depression ', The international journal of neuropsychopharmacology, vol. 26, no. 5, pp. 350–358 . https://doi.org/10.1093/ijnp/pyad016

Background Recent preclinical and clinical studies have shed light on the possible impact of sex and estrous/menstrual cycle on ketamine’s antidepressant action but with incongruous results. The preclinical studies that have shown the effects of ov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c09b4d1a87e9174befbbb93b95fedce8
https://pure.au.dk/portal/da/publications/sex-and-estrous-cycle-are-not-mediators-of-sketamines-rapidantidepressant-behavioral-effects-in-a-genetic-rat-model-of-depression(ca5d12be-7fa8-476a-8535-92f3634fa31b).html

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Regulation of DNA Methylation by Cannabidiol and Its Implications for Psychiatry: New Insights from In Vivo and In Silico Models

Autor: Luana B. Domingos, Nicole R. Silva, Adriano J. M. Chaves Filho, Amanda J. Sales, Anna Starnawska, Sâmia Joca

Publikováno v: Domingos, L B, Silva, N R, Chaves Filho, A J M, Sales, A J, Starnawska, A & Joca, S 2022, ' Regulation of DNA Methylation by Cannabidiol and Its Implications for Psychiatry : New Insights from In Vivo and In Silico Models ', Genes, vol. 13, no. 11 . https://doi.org/10.3390/genes13112165

Cannabidiol (CBD) is a non-psychotomimetic compound present in cannabis sativa. Many recent studies have indicated that CBD has a promising therapeutic profile for stress-related psychiatric disorders, such as anxiety, schizophrenia and depression. S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cd32de50e63018c822c9aaac4ad4ec4
https://pubmed.ncbi.nlm.nih.gov/36421839

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Learned Helplessness in Rodents

Autor: Kennia Moura Silveira, Sâmia Joca

Publikováno v: Neuromethods ISBN: 9781071627471

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::37dc417577a3ac6feda2f749da1254c1
https://doi.org/10.1007/978-1-0716-2748-8_9

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CB1 Receptor Silencing Attenuates Ketamine-Induced Hyperlocomotion Without Compromising Its Antidepressant-Like Effects

Autor: Pedro Henrique Gobira, Jacob LaMar, Jade Marques, Ariandra Sartim, Kennia Silveira, Luana Santos, Gregers Wegener, Francisco S. Guimaraes, Ken Mackie, Hui-Chen Lu, Sâmia Joca

Publikováno v: Gobira, P H, LaMar, J, Marques, J, Sartim, A, Silveira, K, Santos, L, Wegener, G, Guimaraes, F S, Mackie, K, Lu, H-C & Joca, S 2022, ' CB1 Receptor Silencing Attenuates Ketamine-Induced Hyperlocomotion Without Compromising Its Antidepressant-Like Effects ', Cannabis and cannabinoid research . https://doi.org/10.1089/can.2022.0072

Introduction: The antidepressant properties of ketamine have been extensively demonstrated in experimental and clinical settings. However, the psychotomimetic side effects still limit its wider use as an antidepressant. It was recently observed that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9559fd58c63e7d8e380db81b3c57139f
https://doi.org/10.1089/can.2022.0072

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The intersection of astrocytes and the endocannabinoid system in the lateral habenula:on the fast-track to novel rapid-acting antidepressants

Autor: Shokouh Arjmand, Anne M. Landau, Bardia Varastehmoradi, Roberto Andreatini, Sâmia Joca, Gregers Wegener

Publikováno v: Arjmand, S, Landau, A M, Varastehmoradi, B, Andreatini, R, Joca, S & Wegener, G 2022, ' The intersection of astrocytes and the endocannabinoid system in the lateral habenula : on the fast-track to novel rapid-acting antidepressants ', Molecular Psychiatry, vol. 27, no. 8, pp. 3138–3149 . https://doi.org/10.1038/s41380-022-01598-4

Despite attaining significant advances toward better management of depressive disorders, we are still facing several setbacks. Developing rapid-acting antidepressants with sustained effects is an aspiration that requires thinking anew to explore poss

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73c818699907d10ad7ea20c407a00d5b
https://pure.au.dk/portal/da/publications/the-intersection-of-astrocytes-and-the-endocannabinoid-system-in-the-lateral-habenula(d6195e3e-3887-43a8-a196-a44c4268f85d).html

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Combined effects of quetiapine and opioids: A study of autopsy cases, drug users and sedation in rats

Autor: Freja Drost Andersen, Sâmia Joca, Victor Hvingelby, Shokouh Arjmand, Estefano Pinilla, Simon Comerma Steffensen, Ulf Simonsen, Charlotte Uggerhøj Andersen

Publikováno v: Andersen, F D, Joca, S, Hvingelby, V, Arjmand, S, Pinilla, E, Comerma Steffensen, S G, Simonsen, U & Andersen, C U 2022, ' Combined effects of quetiapine and opioids : A study of autopsy cases, drug users and sedation in rats ', Addiction Biology (Online), vol. 27, no. 5, e13214 . https://doi.org/10.1111/adb.13214

Fatal opioid poisonings often involve methadone or morphine. This study aimed to elucidate if quetiapine, a widely used sedative antipsychotic medication, may increase the risk of fatal opioid poisoning by additive inhibitory effects on the central n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3906d42cff3b92ddae4653855566f64d
https://pubmed.ncbi.nlm.nih.gov/36001431

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