Inherited Retinal Dystrophies: Role of Oxidative Stress and Inflammation in Their Physiopathology and Therapeutic Implications

Autor: Pinilla I, Maneu V, Campello L, Fernández-Sánchez L, Martínez-Gil N, Kutsyr O, Sánchez-Sáez X, Sánchez-Castillo C, Lax P, Cuenca N

Publikováno v: Antioxidants
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
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Inherited retinal dystrophies (IRDs) are a large group of genetically and clinically heterogeneous diseases characterized by the progressive degeneration of the retina, ultimately leading to loss of visual function. Oxidative stress and inflammation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::51f62d9f281cc7bec95241bab0eac3cd
https://pubmed.ncbi.nlm.nih.gov/35739983/

Gradual Increase in Environmental Light Intensity Induces Oxidative Stress and Inflammation and Accelerates Retinal Neurodegeneration

Autor: Kutsyr O, Sánchez-Sáez X, Martínez-Gil N, de Juan E, Lax P, Maneu V, Cuenca N

Publikováno v: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
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PURPOSE: Retinitis pigmentosa (RP) is a blinding neurodegenerative disease of the retina that can be affected by many factors. The present study aimed to analyze the effect of different environmental light intensities in rd10 mice retina. METHODS: C5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::b378e063886fd1907065a7485d983d9a
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7441298/

New Nrf2-Inducer Compound ITH12674 Slows the Progression of Retinitis Pigmentosa in the Mouse Model rd10

Autor: Campello L, Kutsyr O, Noailles A, Michalska P, Fernández-Sánchez L, Martínez-Gil N, Ortuño-Lizarán I, Sánchez-Sáez X, de Juan E, Lax P, León R, García AG, Cuenca N, Maneu V

Publikováno v: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
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BACKGROUND/AIMS: It is well established that oxidative stress and inflammation are common pathogenic features of retinal degenerative diseases. ITH12674 is a novel compound that induces the transcription factor Nrf2; in so doing, the molecule exhibit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::2d997cca8c6dd1a97b37c6765d818b9e
https://fundanet.isabial.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=6350

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