Germline-targeting HIV-1 Env vaccination induces VRC01-class antibodies with rare insertions.

Autor: Caniels TG; Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, the Netherlands., Medina-Ramírez M; Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, the Netherlands., Zhang J; Applied Biomedical Science Institute, San Diego, CA, USA., Sarkar A; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Kumar S; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., LaBranche A; Applied Biomedical Science Institute, San Diego, CA, USA., Derking R; Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, the Netherlands., Allen JD; School of Biological Sciences, University of Southampton, Southampton, UK., Snitselaar JL; Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, the Netherlands., Capella-Pujol J; Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, the Netherlands., Sánchez IDM; Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, the Netherlands., Yasmeen A; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY, USA., Diaz M; Applied Biomedical Science Institute, San Diego, CA, USA., Aldon Y; Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, the Netherlands., Bijl TPL; Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, the Netherlands., Venkatayogi S; Department of Surgery, Duke University School of Medicine, Durham, NC, USA., Martin Beem JS; Department of Surgery, Duke University School of Medicine, Durham, NC, USA., Newman A; Department of Surgery, Duke University School of Medicine, Durham, NC, USA., Jiang C; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY, USA., Lee WH; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Pater M; Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, the Netherlands., Burger JA; Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, the Netherlands., van Breemen MJ; Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, the Netherlands., de Taeye SW; Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, the Netherlands., Rantalainen K; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., LaBranche C; Department of Surgery, Duke University School of Medicine, Durham, NC, USA., Saunders KO; Department of Surgery, Duke University School of Medicine, Durham, NC, USA., Montefiori D; Department of Surgery, Duke University School of Medicine, Durham, NC, USA; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA., Ozorowski G; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Crispin M; School of Biological Sciences, University of Southampton, Southampton, UK., Moore JP; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY, USA., Klasse PJ; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY, USA., Haynes BF; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA., Wilson IA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA., Wiehe K; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA., Verkoczy L; Applied Biomedical Science Institute, San Diego, CA, USA. Electronic address: laurent.verkoczy@absinstitute.org., Sanders RW; Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, the Netherlands; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY, USA. Electronic address: r.w.sanders@amsterdamumc.nl.

Publikováno v: Cell reports. Medicine [Cell Rep Med] 2023 Apr 18; Vol. 4 (4), pp. 101003. Date of Electronic Publication: 2023 Apr 11.