Bioequivalence Evaluation in Healthy Volunteers: New Generic Formulations of Sitagliptin and Sitagliptin–Metformin Fixed-Dose Combination Compared with the Originator Products

Autor: Yvonne Schnaars, Sumedh Gaikwad, Ulrike Gottwald-Hostalek, Wolfgang Uhl, Olga Ribot, Kanthikiran V. S. Varanasi, Laura Rodríguez, Javier Torrejón, Luis Gómez

Publikováno v: Diabetes Therapy. 14:347-362

Three studies compared the bioequivalence (BE) of new generic tablet formulations of sitagliptin (100 mg; fasting) and the fixed-dose combination (FDC) of sitagliptin/metformin (50/850 mg, 50/1000 mg; both fed) in healthy volunteers with the same tab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94abacd59ace0a84b3068ac2a60bde4c
https://doi.org/10.1007/s13300-022-01349-2

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Ranolazine in High-Risk Patients With Implanted Cardioverter-Defibrillators

Autor: Wojciech Zareba, James P. Daubert, Christopher A. Beck, David T. Huang, Jeffrey D. Alexis, Mary W. Brown, Kathryn Pyykkonen, Scott McNitt, David Oakes, Changyong Feng, Mehmet K. Aktas, Felix Ayala-Parades, Adrian Baranchuk, Marc Dubuc, Mark Haigney, Alexander Mazur, Craig A. McPherson, L. Brent Mitchell, Andrea Natale, Jonathan P. Piccini, Merritt Raitt, Mayer Y. Rashtian, Claudio Schuger, Stephen Winters, Seth J. Worley, Ohad Ziv, Arthur J. Moss, W. Zareba, K. Pyykkonen, A. Buttaccio, E. Perkins, D. DeGrey, S. Robertson, A.J. Moss, M. Brown, R. Lansing, A. Oberer, B. Polonsky, V. Ross, A. Papernov, S. Schleede, C. Beck, D. Oakes, C. Feng, S. McNitt S, W.J. Hall, A. Moss, J. Daubert, D. Huang, S. Winters, C. Schuger, M. Haigney, J. Piccini, J. Alexis, L. Chen, A. Miller, J.F. Richeson, S. Rosero, V. Kutyifa, A. Shah, G. Lamas, F. Cohn, F. Harrell, I. Piña, J. Poole, M. Sullivan, D. Lathrop, N. Geller, R. Boineau, J. Trondell, L. Cooper, E. Itturiaga, C. Gottlieb, S. Greer, C. Perzanowski, C. McPherson, C. Hedgepeth, C. Assal, T. Salam, I. Woollett, G. Tomassoni, F. Ayala-Paredes, A. Russo, S. Punnam, R. Sangrigoli, S. Sloan, S. Kutalek, A. Sun, D. Lustgarten, G. Monir, D. Haithcock, R. Sorrentino, D. Cannom, J. Kluger, S. Varanasi, M. Rashtian, F. Philippon, R. Berger, M. Mazzella, T. Lessmeier, J. Silver, S. Worley, M. Bernabei, D. Esberg, M. Dixon, P. LeLorier, Y. Greenberg, V. Essebag, G. Venkataraman, T. Shinn, M. Dubuc, G. Turitto, C. Henrikson, M. Mirro, M. Raitt, A. Baranchuk, G. O'Neill, E. Lockwood, M. Vloka, J. Hurwitz, R.H. Mead, P. Somasundarum, E. Aziz, E. Rashba, A. Budzikowski, M. Cox, A. Natale, E. Chung, O. Ziv, F. McGrew, K. Tamirisa, A. Greenspon, M. Estes, S. Taylor, R. Janardhanan, L.B. Mitchell, M. Burke, M. Attari, B. Mikaelian, S. Hsu, J. Conti, A. Mazur, S. Shorofsky, L. Rosenthal, S. Sakaguchi, D. Wolfe, G. Flaker, S. Saba, M. Aktas, P. Mason, A. Shalaby, D. Musat, R. Abraham, K. Ellenbogen, C. Fellows, N. Kavesh, G. Thomas, D. Hemsworth, B. Williamson

Publikováno v: Journal of the American College of Cardiology. 72:636-645

Background Ventricular tachycardia (VT) and ventricular fibrillation (VF) remain a challenging problem in patients with implantable cardioverter-defibrillators (ICDs). Objectives This study aimed to determine whether ranolazine administration decreas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6a3da108e14703d249a00ad70af08bb8
https://doi.org/10.1016/j.jacc.2018.04.086

Lack of Association of Bone Morphogenetic Protein 2 Gene Haplotypes with Bone Mineral Density, Bone Loss, or Risk of Fractures in Men

Autor: Satya S. Varanasi, Stephen P. Tuck, Sarabjit S. Mastana, Elaine Dennison, Cyrus Cooper, Josephine Vila, Roger M. Francis, Harish K. Datta

Publikováno v: Journal of Osteoporosis, Vol 2011 (2011)

Introduction. The association of bone morphogenetic protein 2 (BMP2) with BMD and risk of fracture was suggested by a recent linkage study, but subsequent studies have been contradictory. We report the results of a study of the relationship between B

Externí odkaz: https://doaj.org/article/54c338e58fac46198bd6ab2e5f149363